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Autor:
Wain, LV, Shrine, N, Artigas, MS, Erzurumluoglu, AM, Noyvert, B, Bossini-Castillo, L, Obeidat, M, Henry, AP, Portelli, MA, Hall, RJ, Billington, CK, Rimington, TL, Fenech, AG, John, C, Blake, T, Jackson, VE, Allen, RJ, Prins, BP, Understanding Society Scientific Group, Campbell, A, Porteous, DJ, Jarvelin, M-R, Wielscher, M, James, AL, Hui, J, Wareham, NJ, Zhao, JH, Wilson, JF, Joshi, PK, Stubbe, B, Rawal, R, Schulz, H, Imboden, M, Probst-Hensch, NM, Karrasch, S, Gieger, C, Deary, IJ, Harris, SE, Marten, J, Rudan, I, Enroth, S, Gyllensten, U, Kerr, SM, Polasek, O, Kähönen, M, Surakka, I, Vitart, V, Hayward, C, Lehtimäki, T, Raitakari, OT, Evans, DM, Henderson, AJ, Pennell, CE, Wang, CA, Sly, PD, Wan, ES, Busch, R, Hobbs, BD, Litonjua, AA, Sparrow, DW, Gulsvik, A, Bakke, PS, Crapo, JD, Beaty, TH, Hansel, NN, Mathias, RA, Ruczinski, I, Barnes, KC, Bossé, Y, Joubert, P, Van Den Berge, M, Brandsma, C-A, Paré, PD, Sin, DD, Nickle, DC, Hao, K, Gottesman, O, Dewey, FE, Bruse, SE, Carey, DJ, Kirchner, HL, Geisinger-Regeneron DiscovEHR Collaboration, Jonsson, S, Thorleifsson, G, Jonsdottir, I, Gislason, T, Stefansson, K, Schurmann, C, Nadkarni, G, Bottinger, EP, Loos, RJF, Walters, RG, Chen, Z, Millwood, IY, Vaucher, J, Kurmi, OP, Li, L, Hansell, AL, Brightling, C, Zeggini, E, Cho, MH, Silverman, EK, Sayers, I, Trynka, G, Morris, AP, Strachan, DP, Hall, IP, Tobin, MD
Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function and is the third leading cause of death globally. Through genome-wide association discovery in 48,943 individuals, selected from extremes of the lung function dist
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https://explore.openaire.eu/search/publication?articleId=doi_________::09095b817cfd827c08b1f961881c8b93
Akademický článek
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Autor:
Wain LV; Department of Health Sciences, University of Leicester, Leicester, UK.; National Institute for Health Research, Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK., Shrine N; Department of Health Sciences, University of Leicester, Leicester, UK., Artigas MS; Department of Health Sciences, University of Leicester, Leicester, UK., Erzurumluoglu AM; Department of Health Sciences, University of Leicester, Leicester, UK., Noyvert B; Department of Health Sciences, University of Leicester, Leicester, UK., Bossini-Castillo L; Wellcome Trust Sanger Institute, Hinxton, UK., Obeidat M; University of British Columbia Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, British Columbia, Canada., Henry AP; Division of Respiratory Medicine, University of Nottingham, Nottingham, UK., Portelli MA; Division of Respiratory Medicine, University of Nottingham, Nottingham, UK., Hall RJ; Division of Respiratory Medicine, University of Nottingham, Nottingham, UK., Billington CK; Division of Respiratory Medicine, University of Nottingham, Nottingham, UK., Rimington TL; Division of Respiratory Medicine, University of Nottingham, Nottingham, UK., Fenech AG; Department of Clinical Pharmacology and Therapeutics, University of Malta, Msida, Malta., John C; Department of Health Sciences, University of Leicester, Leicester, UK., Blake T; Department of Health Sciences, University of Leicester, Leicester, UK., Jackson VE; Department of Health Sciences, University of Leicester, Leicester, UK., Allen RJ; Department of Health Sciences, University of Leicester, Leicester, UK., Prins BP; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK., Campbell A; Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK., Porteous DJ; Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK., Jarvelin MR; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Faculty of Medicine, Center for Life Course Health Research, University of Oulu, Oulu, Finland.; Biocenter Oulu, University of Oulu, Oulu, Finland.; Unit of Primary Care, Oulu University Hospital, Oulu, Finland., Wielscher M; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK., James AL; Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.; Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.; School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia., Hui J; Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.; School of Population Health, University of Western Australia, Crawley, Western Australia, Australia.; PathWest Laboratory Medicine of Western Australia, Sir Charles Gairdner Hospital, Crawley, Western Australia, Australia.; School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia, Australia., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK., Zhao JH; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK., Wilson JF; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Joshi PK; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Stubbe B; Department of Internal Medicine B-Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, University Medicine Greifswald, Greifswald, Germany., Rawal R; Research Unit of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Schulz H; Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Neuherberg, Germany., Imboden M; Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland., Probst-Hensch NM; Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland., Karrasch S; Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-Universität, Munich, Germany., Gieger C; Research Unit of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK., Harris SE; Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK., Marten J; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Rudan I; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Enroth S; Department of Immunology, Genetics and Pathology, Uppsala Universitet, Science for Life Laboratory, Uppsala, Sweden., Gyllensten U; Department of Immunology, Genetics and Pathology, Uppsala Universitet, Science for Life Laboratory, Uppsala, Sweden., Kerr SM; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Polasek O; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.; University of Split School of Medicine, Split, Croatia., Kähönen M; Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland., Surakka I; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; National Institute for Health and Welfare (THL), Helsinki, Finland., Vitart V; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Hayward C; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine University of Tampere, Tampere, Finland.; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland., Evans DM; University of Queensland Diamantina Institute, Translational Research Institute, University of Queensland, Brisbane, Queensland, Australia.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Henderson AJ; School of Social and Community Medicine, University of Bristol, Bristol, UK., Pennell CE; School of Women's and Infants' Health, University of Western Australia, Perth, Western Australia, Australia., Wang CA; School of Women's and Infants' Health, University of Western Australia, Perth, Western Australia, Australia., Sly PD; Child Health Research Centre, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia., Wan ES; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA., Busch R; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA., Hobbs BD; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA., Litonjua AA; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA., Sparrow DW; VA Boston Healthcare System, Boston, Massachusetts, USA.; Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA., Gulsvik A; Department of Clinical Science, University of Bergen, Bergen, Norway., Bakke PS; Department of Clinical Science, University of Bergen, Bergen, Norway., Crapo JD; National Jewish Health, Denver, Colorado, USA.; Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, Colorado, USA., Beaty TH; Department of Epidemiology, Johns Hopkins University School of Public Health, Baltimore, Maryland, USA., Hansel NN; Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA., Mathias RA; Division of Allergy and Clinical Immunology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA., Ruczinski I; Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA., Barnes KC; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA., Bossé Y; Department of Molecular Medicine, Laval University, Quebec City, Quebec, Canada.; Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Quebec City, Quebec, Canada., Joubert P; Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Quebec City, Quebec, Canada.; Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University, Quebec City, Quebec, Canada., van den Berge M; University of Groningen, University Medical Center Groningen, Department of Pulmonology, GRIAC Research Institute, Groningen, the Netherlands., Brandsma CA; University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, GRIAC Research Institute, Groningen, the Netherlands., Paré PD; University of British Columbia Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, British Columbia, Canada.; Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Sin DD; University of British Columbia Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, British Columbia, Canada.; Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Nickle DC; Merck Research Laboratories, Genetics and Pharmacogenomics, Boston, Massachusetts, USA., Hao K; Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Gottesman O; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, New York, USA., Dewey FE; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, New York, USA., Bruse SE; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, New York, USA., Carey DJ; Geisinger Health System, Danville, Pennsylvania, USA., Kirchner HL; Geisinger Health System, Danville, Pennsylvania, USA., Jonsson S; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Thorleifsson G; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Jonsdottir I; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland., Gislason T; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.; Department of Respiratory Medicine and Sleep, Landspitali University Hospital Reykjavik, Reykjavik, Iceland., Stefansson K; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland., Schurmann C; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Nadkarni G; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Bottinger EP; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Loos RJ; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Mindich Child Health Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Walters RG; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK., Chen Z; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK., Millwood IY; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, UK., Vaucher J; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK., Kurmi OP; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK., Li L; Chinese Academy of Medical Sciences, Beijing, China.; Department of Epidemiology and Biostatistics, Peking University Health Science Centre, Peking University, Beijing, China., Hansell AL; UK Small Area Health Statistics Unit, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Imperial College Healthcare NHS Trust, St Mary's Hospital, Paddington, London, UK., Brightling C; National Institute for Health Research, Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK.; Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester, Leicester, UK., Zeggini E; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK., Cho MH; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA., Silverman EK; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA., Sayers I; Division of Respiratory Medicine, University of Nottingham, Nottingham, UK., Trynka G; Wellcome Trust Sanger Institute, Hinxton, UK., Morris AP; Department of Biostatistics, University of Liverpool, Liverpool, UK., Strachan DP; Population Health Research Institute, St George's, University of London, London, UK., Hall IP; Division of Respiratory Medicine, University of Nottingham, Nottingham, UK., Tobin MD; Department of Health Sciences, University of Leicester, Leicester, UK.; National Institute for Health Research, Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK.
Publikováno v:
Nature genetics [Nat Genet] 2017 Mar; Vol. 49 (3), pp. 416-425. Date of Electronic Publication: 2017 Feb 06.