Metalloprotease domain latency protects ADAMTS13 against broad-spectrum inhibitors of metalloproteases while maintaining activity toward VWF

Autor: Singh, Kanwal, Madarati, Hasam, Sohrabipour, Sahar, Sparring, Taylor, Teney, Cherie, Kretz, Colin A.

Publikováno v: In Journal of Thrombosis and Haemostasis July 2023 21(7):1789-1801

Current mouse models used to study von Willebrand Factor in thrombosis, hemostasis, and inflammation: a scoping review

Autor: DeYoung, Veronica, Arora, Jaskirat, Kodeeswaran, Arthane, Kretz, Colin, Sparring, Taylor

Mouse models are a critical component to the study of human health. They provide a safe medium through which to study these mechanisms, and to gather evidence to help inform clinical treatment, diagnosis, and prognosis of associated disease. While th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0c625e2d8e0383c02a4781217a22800

Optimization of plasma-based BioID identifies plasminogen as a ligand of ADAMTS13.

Autor: Madarati H; Department of Medicine, Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, ON, Canada., DeYoung V; Department of Medicine, Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, ON, Canada., Singh K; Department of Medicine, Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, ON, Canada., Sparring T; Department of Medicine, Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, ON, Canada., Kwong AC; Department of Medicine, Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, ON, Canada., Fredenburgh JC; Department of Medicine, Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, ON, Canada., Teney C; Department of Medicine, Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, ON, Canada., Koschinsky ML; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Robarts Research Institute, The University of Western Ontario, London, ON, Canada., Boffa MB; Department of Biochemistry, Schulich School of Medicine and Dentistry, Robarts Research Institute, The University of Western Ontario, London, ON, Canada., Weitz JI; Department of Medicine, Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, ON, Canada., Kretz CA; Department of Medicine, Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, ON, Canada. colin.kretz@taari.ca.

Publikováno v: Scientific reports [Sci Rep] 2024 Apr 20; Vol. 14 (1), pp. 9073. Date of Electronic Publication: 2024 Apr 20.