Conserved long noncoding RNA TILAM promotes liver fibrosis through interaction with PML in HSCs.

Autor: Sun C; Department of Medicine, Division of Gastroenterology, Chan Medical School, University of Massachusetts, Worcester, Massachusetts, USA., Zhou C; Department of Population and Quantitative Health Sciences, Chan Medical School, University of Massachusetts, Worcester, Massachusetts USA., Daneshvar K; Department of Medicine, Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Ben Saad A; Department of Medicine, Division of Gastroenterology, Chan Medical School, University of Massachusetts, Worcester, Massachusetts, USA., Kratkiewicz AJ; Department of Medicine, Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Toles BJ; Department of Medicine, Division of Gastroenterology, Chan Medical School, University of Massachusetts, Worcester, Massachusetts, USA., Arghiani N; Department of Medicine, Division of Gastroenterology, Chan Medical School, University of Massachusetts, Worcester, Massachusetts, USA., Hess A; Department of Medicine, Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Chen JY; Department of Medicine, Liver Center, University of California, San Francisco, California, USA., Pondick JV; Department of Medicine, Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., York SR; Department of Medicine, Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Li W; Department of Medicine, Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Moran SP; Department of Medicine, Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Gentile SD; Department of Medicine, Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute, Cambridge, Massachusetts, USA., Rahman RU; Department of Medicine, Division of Gastroenterology, Chan Medical School, University of Massachusetts, Worcester, Massachusetts, USA.; Broad Institute, Cambridge, Massachusetts, USA., Li Z; Department of Population and Quantitative Health Sciences, Chan Medical School, University of Massachusetts, Worcester, Massachusetts USA., Zhou P; Department of Population and Quantitative Health Sciences, Chan Medical School, University of Massachusetts, Worcester, Massachusetts USA., Sparks RP; Department of Medicine, Division of Gastroenterology, Chan Medical School, University of Massachusetts, Worcester, Massachusetts, USA., Habboub T; Department of Medicine, Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Kim BM; Department of Medicine, Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Choi MY; Department of Medicine, Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Affo S; Department of Liver, Digestive System, and Metabolism, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain., Schwabe RF; Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA., Popov YV; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Mullen AC; Department of Medicine, Division of Gastroenterology, Chan Medical School, University of Massachusetts, Worcester, Massachusetts, USA.; Broad Institute, Cambridge, Massachusetts, USA.

Publikováno v: Hepatology (Baltimore, Md.) [Hepatology] 2024 Apr 02. Date of Electronic Publication: 2024 Apr 02.

Small molecule targeting long noncoding RNA GAS5 administered intranasally improves neuronal insulin signaling and decreases neuroinflammation in an aged mouse model.

Autor: Patel RS; James A. Haley Veterans Hospital, Research Service, 13000 Bruce B. Downs Blvd., Tampa, FL, 33612, USA., Lui A; Department of Molecular Medicine, University of South Florida, Tampa, FL, 33612, USA., Hudson C; James A. Haley Veterans Hospital, Research Service, 13000 Bruce B. Downs Blvd., Tampa, FL, 33612, USA., Moss L; Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL, 33612, USA., Sparks RP; UMass Chan Medical School, Worcester, MA, 01655, USA., Hill SE; Department of Molecular Medicine, University of South Florida, Tampa, FL, 33612, USA.; USF Health Byrd Institute, University of South Florida, Tampa, FL, 33612, USA., Shi Y; Department of Chemistry, University of South Florida, Tampa, FL, 33612, USA., Cai J; Department of Chemistry, University of South Florida, Tampa, FL, 33612, USA., Blair LJ; James A. Haley Veterans Hospital, Research Service, 13000 Bruce B. Downs Blvd., Tampa, FL, 33612, USA.; Department of Molecular Medicine, University of South Florida, Tampa, FL, 33612, USA.; USF Health Byrd Institute, University of South Florida, Tampa, FL, 33612, USA., Bickford PC; James A. Haley Veterans Hospital, Research Service, 13000 Bruce B. Downs Blvd., Tampa, FL, 33612, USA.; Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL, 33612, USA., Patel NA; James A. Haley Veterans Hospital, Research Service, 13000 Bruce B. Downs Blvd., Tampa, FL, 33612, USA. Niketa.Patel@va.gov.; Department of Molecular Medicine, University of South Florida, Tampa, FL, 33612, USA. Niketa.Patel@va.gov.

Publikováno v: Scientific reports [Sci Rep] 2023 Jan 06; Vol. 13 (1), pp. 317. Date of Electronic Publication: 2023 Jan 06.

Induction of beige-like adipocyte markers and functions in 3T3-L1 cells by Clk1 and PKCβII inhibitory molecules.

Autor: Patel A; Department of Molecular Medicine, University of South Florida Morsani College of Medicine, Tampa, Florida, USA., Dobbins T; Department of Molecular Medicine, University of South Florida Morsani College of Medicine, Tampa, Florida, USA., Kong X; Department of Molecular Medicine, University of South Florida Morsani College of Medicine, Tampa, Florida, USA., Patel R; Department of Molecular Medicine, University of South Florida Morsani College of Medicine, Tampa, Florida, USA., Carter G; J.A. Haley Research Service, Tampa, Florida, USA., Harding L; Department of Chemistry, University of South Florida, Tampa, Florida, USA., Sparks RP; Department of Chemistry, University of South Florida, Tampa, Florida, USA., Patel NA; Department of Molecular Medicine, University of South Florida Morsani College of Medicine, Tampa, Florida, USA.; J.A. Haley Research Service, Tampa, Florida, USA., Cooper DR; Department of Molecular Medicine, University of South Florida Morsani College of Medicine, Tampa, Florida, USA.; J.A. Haley Research Service, Tampa, Florida, USA.

Publikováno v: Journal of cellular and molecular medicine [J Cell Mol Med] 2022 Aug; Vol. 26 (15), pp. 4183-4194. Date of Electronic Publication: 2022 Jul 08.

Use of Microscale Thermophoresis to Measure Protein-Lipid Interactions.

Autor: Sparks RP; Department of Biochemistry, University of Illinois at Urbana-Champaign., Lawless W; Department of Chemistry, University of South Florida., Arango AS; Department of Biochemistry, University of Illinois at Urbana-Champaign; Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign., Tajkhorshid E; Department of Biochemistry, University of Illinois at Urbana-Champaign; Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign., Fratti RA; Department of Biochemistry, University of Illinois at Urbana-Champaign; Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign; rfratti@illinois.edu.

Publikováno v: Journal of visualized experiments : JoVE [J Vis Exp] 2022 Feb 10 (180). Date of Electronic Publication: 2022 Feb 10.

A small-molecule competitive inhibitor of phosphatidic acid binding by the AAA+ protein NSF/Sec18 blocks the SNARE-priming stage of vacuole fusion.

Autor: Sparks RP; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801., Arango AS; Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801., Starr ML; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801., Aboff ZL; Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801., Hurst LR; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801., Rivera-Kohr DA; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801., Zhang C; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801., Harnden KA; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801., Jenkins JL; Structural Biology and Biophysics Facility, University of Rochester Medical Center, Rochester, New York 14642., Guida WC; Department of Chemistry, University of South Florida, Tampa, Florida 336204., Tajkhorshid E; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.; Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801., Fratti RA; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801 rfratti@illinois.edu.; Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2019 Nov 15; Vol. 294 (46), pp. 17168-17185. Date of Electronic Publication: 2019 Sep 12.