Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Spandan V. Shah"'
Autor:
Rhianna Jones, Kyle Kroll, Courtney Broedlow, Luca Schifanella, Scott Smith, Brady Hueber, Spandan V. Shah, Daniel R. Ram, Cordelia Manickam, Valerie Varner, Nichole R. Klatt, R. Keith Reeves
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract HIV/SIV infections lead to massive loss of mucosal CD4 + T cells and breakdown of the epithelial mucosa resulting in severe microbial dysbiosis and chronic immune activation that ultimately drive disease progression. Moreover, disruption of
Externí odkaz:
https://doaj.org/article/48692deb9b0a4041ad526778e7eb2847
Autor:
Daniel R. Ram, Christian F. Arias, Kyle Kroll, Brady Hueber, Cordelia Manickam, Rhianna A. Jones, Scott T. Smith, Spandan V. Shah, Valerie H. Varner, R. Keith Reeves
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
CD49a+ tissue resident NK cells have been implicated in memory-like NK cell responses, but while this population is well-characterized in mice and in humans, they are poorly described in non-human primates (NHP) which are particularly critical for mo
Externí odkaz:
https://doaj.org/article/9eeae46805a54c70aba19b788327a6de
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Natural killer (NK) cells are the major innate effectors primed to eliminate virus-infected and tumor or neoplastic cells. Recent studies also suggest nuances in phenotypic and functional characteristics among NK cell subsets may further permit execu
Externí odkaz:
https://doaj.org/article/56be07f479da4e82bfefd31ac917860d
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Viral infections trigger robust secretion of interferons and other antiviral cytokines by infected and bystander cells, which in turn can tune the immune response and may lead to viral clearance or immune suppression. However, aberrant or unrestricte
Externí odkaz:
https://doaj.org/article/ebca2f8f04764258aa166077bedb1d0b
Autor:
Spandan V. Shah, Cordelia Manickam, Daniel R. Ram, Kyle Kroll, Hannah Itell, Sallie R. Permar, Dan H. Barouch, Nichole R. Klatt, R. Keith Reeves
Publikováno v:
Cell Reports, Vol 25, Iss 10, Pp 2766-2774.e3 (2018)
Summary: Despite burgeoning evidence demonstrating the adaptive properties of natural killer (NK) cells, mechanistic data explaining these phenomena are lacking. Following antibody sensitization, NK cells lacking the Fc receptor (FcR) signaling chain
Externí odkaz:
https://doaj.org/article/b1b79024dacf4c05b753314b715b4331
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Over the past several years, new populations of innate lymphocytes have been described in mice and primates that are critical for mucosal homeostasis, microbial regulation, and immune defense. Generally conserved from mice to humans, innate lymphoid
Externí odkaz:
https://doaj.org/article/53993c3b26e544188da83c123b535d82
Autor:
Kyle W. Kroll, Spandan V. Shah, Olivier A. Lucar, Thomas A. Premeaux, Cecilia M. Shikuma, Michael J. Corley, Matthew Mosher, Griffin Woolley, Scott Bowler, Lishomwa C. Ndhlovu, R. Keith Reeves
Publikováno v:
Cell reports. Medicine. 3(10)
Natural killer (NK) cells are critical modulators of HIV transmission and disease. Recent evidence suggests a loss of NK cell cytotoxicity during aging, yet analysis of NK cell biology and aging in people with HIV (PWH) is lacking. Herein, we perform
Autor:
Kyle W. Kroll, Spandan V. Shah, Olivier A. Lucar, Thomas A. Premeaux, Cecilia M. Shikuma, Michael J. Corley, Matthew Mosher, Scott Bowler, Lishomwa C. Ndhlovu, R. Keith Reeves
Natural killer (NK) cells are critical modulators of HIV transmission and disease. While recent evidence suggests a loss of NK cell cytotoxicity during aging, a compound analysis of NK cell biology and aging in persons with HIV (PWH) is lacking. We s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::242b52041292753e43faf93523a7d5cd
https://doi.org/10.1101/2022.01.05.475089
https://doi.org/10.1101/2022.01.05.475089
Autor:
Scott Smith, Rhianna Jones, Kyle Kroll, Daniel R. Ram, Spandan V. Shah, Griffin Woolley, Cordelia Manickam, R. Keith Reeves, Valerie Varner, Brady Hueber
Publikováno v:
Immunology
Granulocytes mediate broad immunoprotection through phagocytosis, extracellular traps, release of cytotoxic granules, antibody effector functions and recruitment of other immune cells against pathogens. However, descriptions of granulocytes in HIV in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb2f58bf1225501b03594f5928394ab
https://europepmc.org/articles/PMC8442246/
https://europepmc.org/articles/PMC8442246/
Publikováno v:
Journal of Leukocyte Biology. 105:1253-1259
NK cells play a critical role in antiviral and antitumor responses. Although current NK cell immune therapies have focused primarily on cancer biology, many of these advances can be readily applied to target HIV/simian immunodeficiency virus (SIV)-in