Zobrazeno 1 - 10
of 1 460
pro vyhledávání: '"Span, P."'
Higher-order solitons inherently possess a spatial periodicity along the propagation axis. The pulse expands and compresses in both, frequency and time domain. This property is exploited for a bandwidth-limited receiver by sampling the optical signal
Externí odkaz:
http://arxiv.org/abs/2304.05920
Autor:
Daan F. Boreel, Anne P.M. Beerkens, Sandra Heskamp, Milou Boswinkel, Johannes P.W. Peters, Gosse J. Adema, Paul N. Span, Johan Bussink
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 49, Iss , Pp 100875- (2024)
Introduction: Tumor hypoxia is a feature of many solid malignancies and is known to cause radio resistance. In recent years it has become clear that hypoxic tumor regions also foster an immunosuppressive phenotype and are involved in immunotherapy re
Externí odkaz:
https://doaj.org/article/cae6230e8058466b98f4a09faac3e1ce
Autor:
Eline JH van Houtum, Anne HC Valk, Daniel Granado, Jasper Lok, Lune van den Bogaard, Naomi Remkes, Jesper van Eck van der Sluijs, Paul N Span, Lenneke AM Cornelissen, Gosse J Adema
Publikováno v:
Clinical & Translational Immunology, Vol 13, Iss 9, Pp n/a-n/a (2024)
Abstract Objectives PD‐1/PD‐L1 immune checkpoint blockade can be an effective treatment for advanced breast cancer patients. However, patients with oestrogen receptor positive (ER+) tumors often display only low lymphocyte infiltration, while a l
Externí odkaz:
https://doaj.org/article/c10814c5d7244fc29c3f29ede665bafe
Autor:
Anne P. M. Beerkens, Daan F. Boreel, James A. Nathan, Jiri Neuzil, Gang Cheng, Balaraman Kalyanaraman, Micael Hardy, Gosse J. Adema, Sandra Heskamp, Paul N. Span, Johan Bussink
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-10 (2024)
Abstract Background Hypoxia is a common feature of many solid tumors and causes radiotherapy and immunotherapy resistance. Pharmacological inhibition of oxidative phosphorylation (OXPHOS) has emerged as a therapeutic strategy to reduce hypoxia. Howev
Externí odkaz:
https://doaj.org/article/6158a99077a34dd2a03b9ab6923fa43f
Pulse shaping for coherent optical fiber communication has been an active area of research for the past decade. Most of the early schemes are based on classic Nyquist pulse shaping that was originally intended for linear channels. The best known clas
Externí odkaz:
http://arxiv.org/abs/2207.06089
Autor:
Bas P. H. Adriaansen, Agustini Utari, Dineke Westra, Achmad Zulfa Juniarto, Mahayu Dewi Ariani, Annastasia Ediati, Mariska A. M. Schröder, Paul N. Span, Fred C. G. J. Sweep, Stenvert L. S. Drop, Sultana M. H. Faradz, Antonius E. van Herwaarden, Hedi L. Claahsen – van der Grinten
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionCongenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD) or 11-hydroxylase deficiency (11OHD) is characterized by underproduction of cortisol and overproduction of adrenal androgens. These androgens lead to a variable
Externí odkaz:
https://doaj.org/article/48f6cb3fd87c455992e4f56a2d178f4c
Autor:
Sylvia D. Klomp, Anette Veringa, Jan‐Willem C. Alffenaar, Mark G. J. deBoer, Lambert F. R. Span, Henk‐Jan Guchelaar, Jesse J. Swen
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 7, Pp n/a-n/a (2024)
Abstract Voriconazole is the cornerstone of the treatment and prevention of fungal infections. While there is a good correlation between CYP2C19 genotype and voriconazole exposure during prophylactic treatment, no correlation was found in patients wi
Externí odkaz:
https://doaj.org/article/6d2407fc26434dd2b9215c84b25c3c29
Autor:
F.V. Naumann, J.H.A.M. Kaanders, W.J.M. Peeters, G.J. Adema, F.C.G.J. Sweep, J. Bussink, P.N. Span
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 45, Iss , Pp 100726- (2024)
Background and purpose: Radiotherapy (RT) is a mainstay component of treatment for patients with head and neck squamous cell carcinoma (HNSCC), but responses vary. As RT relies upon oxidative damage, antioxidant expression in response to RT-induced r
Externí odkaz:
https://doaj.org/article/d80a70f6c98a41f691a9c9a2333fa5ed
Autor:
Ha-Linh Nguyen, Tatjana Geukens, Marion Maetens, Samuel Aparicio, Ayse Bassez, Ake Borg, Jane Brock, Annegien Broeks, Carlos Caldas, Fatima Cardoso, Maxim De Schepper, Mauro Delorenzi, Caroline A. Drukker, Annuska M. Glas, Andrew R. Green, Edoardo Isnaldi, Jórunn Eyfjörð, Hazem Khout, Stian Knappskog, Savitri Krishnamurthy, Sunil R. Lakhani, Anita Langerod, John W. M. Martens, Amy E. McCart Reed, Leigh Murphy, Stefan Naulaerts, Serena Nik-Zainal, Ines Nevelsteen, Patrick Neven, Martine Piccart, Coralie Poncet, Kevin Punie, Colin Purdie, Emad A. Rakha, Andrea Richardson, Emiel Rutgers, Anne Vincent-Salomon, Peter T. Simpson, Marjanka K. Schmidt, Christos Sotiriou, Paul N. Span, Kiat Tee Benita Tan, Alastair Thompson, Stefania Tommasi, Karen Van Baelen, Marc Van de Vijver, Steven Van Laere, Laura van’t Veer, Giuseppe Viale, Alain Viari, Hanne Vos, Anke T. Witteveen, Hans Wildiers, Giuseppe Floris, Abhishek D. Garg, Ann Smeets, Diether Lambrechts, Elia Biganzoli, François Richard, Christine Desmedt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Obesity is associated with an increased risk of developing breast cancer (BC) and worse prognosis in BC patients, yet its impact on BC biology remains understudied in humans. This study investigates how the biology of untreated primary BC di
Externí odkaz:
https://doaj.org/article/449fce543ad84736bc9d60953aa2df60
Autor:
Spanbauer, Span, Hunter, Ian
We demonstrate a novel algorithm for generating stationary stochastic signals with a specified power spectral density (or equivalently, via the Wiener-Khinchin relation, a specified autocorrelation function) while satisfying constraints on the signal
Externí odkaz:
http://arxiv.org/abs/2010.06840