Výsledky vyhledávání - "Sp1, specificity protein 1"

LLGL1 Regulates Gemcitabine Resistance by Modulating the ERK-SP1-OSMR Pathway in Pancreatic Ductal AdenocarcinomaSummary

Autor: Yangchao Chen, Tian Xia, Guolin Li, Frederic Khe Cheong Fung, Ka Fai To, Joanna H.M. Tong, Chi Han Li, Yin-Xin Zhu, Chi Hin Wong, Huiyi Feng, Rufu Chen

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 4, Pp 811-828 (2020)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Gemcitabine resistance is rapidly acquired by pancreatic ductal adenocarcinoma (PDAC) patients. Novel approaches that predict the gemcitabine response of patients and enhance gemcitabine chemosensitivity are important to improve pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::522e00f260ff434833ed2e958f307cb5
http://www.sciencedirect.com/science/article/pii/S2352345X20300989

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Tumor necrosis factor α upregulates the bile acid efflux transporter OATP3A1 via multiple signaling pathways in cholestasis

Autor: Mingqiao Li, Weihua Wang, Ying Cheng, Xiaoxun Zhang, Nan Zhao, Ya Tan, Qiaoling Xie, Jin Chai, Qiong Pan

Publikováno v: The Journal of Biological Chemistry

Cholestasis is a common condition in which the flow of bile from the liver to the intestines is inhibited. It has been shown that organic anion–transporting polypeptide 3A1 (OATP3A1) is upregulated in cholestasis to promote bile acid efflux transpo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87568537078818c628c5dc973f5fcc6f
https://pubmed.ncbi.nlm.nih.gov/34971708

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Sp1 is a substrate of Keap1 and regulates the activity of CRL4AWDR23 ubiquitin ligase toward Nrf2

Autor: Ferbian Milas Siswanto, Ami Oguro, Susumu Imaoka

Publikováno v: The Journal of Biological Chemistry

Nuclear factor erythroid 2–related factor 2 (Nrf2) is a critical transcription factor that orchestrates cellular responses to oxidative stress. Because the dysregulation of Nrf2 has been implicated in many diseases, precise regulation of its protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707cf01346d6f8bd9189f7ef3b137d58
http://europepmc.org/articles/PMC8141886

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Vanadate inhibits transcription of the rat insulin receptor gene via a proximal sequence of the 5′flanking region

Autor: Sylvie Bortoli, Bernard Desbuquois, Martine Collinet

Publikováno v: Biochimie Open, Vol 7, Iss, Pp 26-32 (2018)
Biochimie Open

Vanadate, a protein tyrosine phosphatase inhibitor which elicits insulin-like effects, has previously been shown to inhibit expression of the insulin receptor gene at the transcriptional level in rat hepatoma cells. In an attempt to identify the DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32f28a98099c18d8f778c71445315c4d
https://doi.org/10.1016/j.biopen.2018.09.001

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Effects of the stimuli-dependent enrichment of 8-oxoguanine DNA glycosylase1 on chromatinized DNA

Autor: Spiros Vlahopoulos, Zsolt Radak, Attila Bacsi, Bing Zhu, Leopoldo Aguilera-Aguirre, Allan R. Brasier, Xueqing Ba, Ruoxi Wang, Wenjing Hao, Tapas K. Hazra, Lang Pan, Istvan Boldogh, Tianyang Qi

Publikováno v: Redox Biology, Vol 18, Iss, Pp 43-53 (2018)
Redox Biology

8-Oxoguanine DNA glycosylase 1 (OGG1) initiates the base excision repair pathway by removing one of the most abundant DNA lesions, 8-oxo-7,8-dihydroguanine (8-oxoG). Recent data showed that 8-oxoG not only is a pro-mutagenic genomic base lesion, but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa78aa331af47be4e5a92c2e745491dc
http://www.sciencedirect.com/science/article/pii/S2213231718303562

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Developing the next generation of graphene-based platforms for cancer therapeutics: The potential role of reactive oxygen species

Autor: Tanveer A. Tabish, Shaowei Zhang, Paul G. Winyard

Publikováno v: Redox Biology
Redox Biology, Vol 15, Iss C, Pp 34-40 (2018)

Graphene has a promising future in applications such as disease diagnosis, cancer therapy, drug/gene delivery, bio-imaging and antibacterial approaches owing to graphene's unique physical, chemical and mechanical properties alongside minimal toxicity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b3b12c807fdcf7ce46e0475c4ee8c8d3
http://europepmc.org/articles/PMC5723279

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Targeting Epigenetic Mechanisms to Alleviate Alcoholic Steatosis

Autor: Pranoti Mandrekar

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 4, Pp 713-714 (2020)
Cellular and Molecular Gastroenterology and Hepatology

Ethanol-mediated down-regulation of carnitine palmitoyltransferase-1 (CPT-1A) gene expression plays a major role in the development of hepatic steatosis; however, the underlying mechanisms are not completely elucidated. Tributyrin, a butyrate prodrug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a04df33849ebec31c64322af3924eadf
http://www.sciencedirect.com/science/article/pii/S2352345X20300205

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Deciphering Genetic Regulation of CD14 by SP1 Through Characterization of Peripheral Blood Mononuclear Transcriptome of P. Falciparum and P. Vivax Infected Malaria Patients

Autor: Chandrima Das, Pragya Gajendra, Mitashree Mitra, Sanghamitra Sengupta, Bijurica Chakraborty, Payel Mondal

Publikováno v: EBioMedicine

Background Plasmodium falciparum and Plasmodium vivax are two major parasites responsible for malaria which remains a threat to almost 50% of world's population despite decade-long eradication program. One possible reason behind this conundrum is tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41692a5ad48ef4b249dc9f066c35f199
https://doi.org/10.2139/ssrn.3209544

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Human retinal pigment epithelial cell proliferation by the combined stimulation of hydroquinone and advanced glycation end-products via up-regulation of VEGF gene

Autor: Hiroki Tsujinaka, Maiko Takeda, Akiyo Yamauchi, Sumiyo Sakuramoto-Tsuchida, Asako Itaya-Hironaka, Nahoko Ogata, Takanori Fujimura, Hiroyo Ota, Shin Takasawa

Publikováno v: Biochemistry and Biophysics Reports

Although recent research showed that advanced glycation endproduct (AGE) and hydroquinone (HQ) are related to the pathogenesis of age-related macular degeneration (AMD), the mechanism how AGE and HQ induce or accelerate AMD remains elusive. In the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad3b794b2136a4b27338d99bf6e72509
https://doi.org/10.1016/j.bbrep.2015.05.005

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A new tumour suppression mechanism by p27Kip1: EGFR down-regulation mediated by JNK/c-Jun pathway inhibition

Autor: Yong Fang, Chuanshu Huang, Dongyun Zhang, Honglei Jin, Xue-Ru Wu, Jingxia Li, Yihong Wang, Junlan Zhu, Yan Meng, Yonghui Yu, Yulei Wang

Publikováno v: Biochemical Journal

p27Kip1 is a potent inhibitor of cyclin-dependent kinases that drive G1-to-S cell-cycle transition. Reduced p27Kip1 expression is prevalent in a wide range of human tumours; however, the exact mechanism(s) of p27Kip1-mediated tumour suppression remai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eeb2c52881a3c77cbf792903d242921
http://europepmc.org/articles/PMC4209780

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