[A lentivirus vector based assay system for quantitative detection of intracellular translocations of recombinant proteins]

Autor: Sp, Chumakov, Gv, Il Inskaia, Kravchenko IuE, Ei, Frolova, Vs, Prasolov, Peter Chumakov

Publikováno v: Europe PubMed Central

An enzymatic assay system is described that allows quantitative localization within different cellular structures of recombinant proteins. The system is based on alpha-complementation of beta-galactosidase. The large omega-fragment of beta-galactosid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::02f127d1c6a1399499eb466dd096f549
https://pubmed.ncbi.nlm.nih.gov/19140320

Alkyl Derivatives of Perylene Photosensitizing Antivirals: Towards Understanding the Influence of Lipophilicity.

Autor: Mikhnovets IE; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia., Holoubek J; Laboratory of Emerging Viral Diseases, Veterinary Research Institute, Hudcova 296/70, CZ-621 00 Brno, Czech Republic.; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Branišovská 1160/31, CZ-370 05 České Budějovice, Czech Republic.; Department of Experimental Biology, Faculty of Science, Masaryk University, CZ-625 00 Brno, Czech Republic., Panina IS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia., Kotouček J; Department of Pharmacology and Toxicology, Veterinary Research Institute, Hudcova 296/70, CZ-621 00 Brno, Czech Republic., Gvozdev DA; Department of Biology, Lomonosov Moscow State University, Leninskie Gory 1-12, 119234 Moscow, Russia., Chumakov SP; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia., Krasilnikov MS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.; Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1-3, 119991 Moscow, Russia., Zhitlov MY; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.; Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1-3, 119991 Moscow, Russia., Gulyak EL; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia., Chistov AA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia., Nikitin TD; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia., Korshun VA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia., Efremov RG; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia., Alferova VA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia., Růžek D; Laboratory of Emerging Viral Diseases, Veterinary Research Institute, Hudcova 296/70, CZ-621 00 Brno, Czech Republic.; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Branišovská 1160/31, CZ-370 05 České Budějovice, Czech Republic.; Department of Experimental Biology, Faculty of Science, Masaryk University, CZ-625 00 Brno, Czech Republic., Eyer L; Laboratory of Emerging Viral Diseases, Veterinary Research Institute, Hudcova 296/70, CZ-621 00 Brno, Czech Republic.; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Branišovská 1160/31, CZ-370 05 České Budějovice, Czech Republic.; Department of Experimental Biology, Faculty of Science, Masaryk University, CZ-625 00 Brno, Czech Republic., Ustinov AV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Nov 18; Vol. 24 (22). Date of Electronic Publication: 2023 Nov 18.

5-(Perylen-3-ylethynyl)uracil as an antiviral scaffold: Potent suppression of enveloped virus reproduction by 3-methyl derivatives in vitro.

Autor: Chistov AA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia., Chumakov SP; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia., Mikhnovets IE; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia; Department of Chemistry, Lomonosov Moscow State University, Moscow, 119991, Russia., Nikitin TD; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia; Department of Chemistry, Lomonosov Moscow State University, Moscow, 119991, Russia., Slesarchuk NA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia., Uvarova VI; FSASI 'Chumakov FSC R&D IBP RAS' (Institute of Poliomyelitis), Moscow, 108819, Russia., Rubekina AA; Department of Physics, Lomonosov Moscow State University, Moscow, 119991, Russia., Nikolaeva YV; Smorodintsev Research Institute of Influenza, St. Petersburg, 197376, Russia., Radchenko EV; Department of Chemistry, Lomonosov Moscow State University, Moscow, 119991, Russia., Khvatov EV; FSASI 'Chumakov FSC R&D IBP RAS' (Institute of Poliomyelitis), Moscow, 108819, Russia., Orlov AA; Department of Chemistry, Lomonosov Moscow State University, Moscow, 119991, Russia; FSASI 'Chumakov FSC R&D IBP RAS' (Institute of Poliomyelitis), Moscow, 108819, Russia; Skolkovo Institute of Science and Technology, 143026, Moscow Region, Russia., Frolenko VS; FSASI 'Chumakov FSC R&D IBP RAS' (Institute of Poliomyelitis), Moscow, 108819, Russia; Institute of Translational Medicine and Biotechnology, Sechenov Moscow State Medical University, Moscow, 119991, Russia., Sukhorukov MV; Department of Chemistry, Lomonosov Moscow State University, Moscow, 119991, Russia; FSASI 'Chumakov FSC R&D IBP RAS' (Institute of Poliomyelitis), Moscow, 108819, Russia., Kolpakova ES; FSASI 'Chumakov FSC R&D IBP RAS' (Institute of Poliomyelitis), Moscow, 108819, Russia., Shustova EY; FSASI 'Chumakov FSC R&D IBP RAS' (Institute of Poliomyelitis), Moscow, 108819, Russia., Galochkina AV; Smorodintsev Research Institute of Influenza, St. Petersburg, 197376, Russia., Streshnev PP; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia., Osipov EM; Laboratory for Biocrystallography, Department of Pharmaceutical and Pharmacological Sciences, Katholieke Universiteit Leuven, 3000, Leuven, Belgium., Sapozhnikova KA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia., Moiseenko AV; Department of Biology, Moscow State University, Moscow, 119991, Russia., Brylev VA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia; Lumiprobe RUS Ltd., Moscow, 121351, Russia., Proskurin GV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia., Dokukin YS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia., Kutyakov SV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia., Aralov AV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia., Korshun VA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia., Strelkov SV; Laboratory for Biocrystallography, Department of Pharmaceutical and Pharmacological Sciences, Katholieke Universiteit Leuven, 3000, Leuven, Belgium., Palyulin VA; Department of Chemistry, Lomonosov Moscow State University, Moscow, 119991, Russia., Ishmukhametov AA; FSASI 'Chumakov FSC R&D IBP RAS' (Institute of Poliomyelitis), Moscow, 108819, Russia; Institute of Translational Medicine and Biotechnology, Sechenov Moscow State Medical University, Moscow, 119991, Russia., Shirshin EA; Department of Physics, Lomonosov Moscow State University, Moscow, 119991, Russia., Osolodkin DI; FSASI 'Chumakov FSC R&D IBP RAS' (Institute of Poliomyelitis), Moscow, 108819, Russia; Institute of Translational Medicine and Biotechnology, Sechenov Moscow State Medical University, Moscow, 119991, Russia., Shtro AA; Smorodintsev Research Institute of Influenza, St. Petersburg, 197376, Russia., Kozlovskaya LI; FSASI 'Chumakov FSC R&D IBP RAS' (Institute of Poliomyelitis), Moscow, 108819, Russia; Institute of Translational Medicine and Biotechnology, Sechenov Moscow State Medical University, Moscow, 119991, Russia. Electronic address: lubov_i_k@mail.ru., Alferova VA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia. Electronic address: alferovava@gmail.com., Ustinov AV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia; Lumiprobe RUS Ltd., Moscow, 121351, Russia. Electronic address: austinov@yandex.ru.

Publikováno v: Antiviral research [Antiviral Res] 2023 Jan; Vol. 209, pp. 105508. Date of Electronic Publication: 2022 Dec 26.

Engineered Removal of PD-1 From the Surface of CD19 CAR-T Cells Results in Increased Activation and Diminished Survival.

Autor: Kalinin RS; M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia., Ukrainskaya VM; M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia., Chumakov SP; M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia., Moysenovich AM; Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia., Tereshchuk VM; M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia., Volkov DV; M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia., Pershin DS; Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia., Maksimov EG; Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia., Zhang H; State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China., Maschan MA; Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia., Rubtsov YP; M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia., Stepanov AV; M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia.; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, United States.

Publikováno v: Frontiers in molecular biosciences [Front Mol Biosci] 2021 Oct 13; Vol. 8, pp. 745286. Date of Electronic Publication: 2021 Oct 13 (Print Publication: 2021).

PDLIM4/RIL-mediated regulation of Src and malignant properties of breast cancer cells.

Autor: Kravchenko DS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia., Ivanova AE; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia., Podshivalova ES; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia., Chumakov SP; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia.

Publikováno v: Oncotarget [Oncotarget] 2020 Jan 07; Vol. 11 (1), pp. 22-30. Date of Electronic Publication: 2020 Jan 07 (Print Publication: 2020).