Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Soya Shinkai"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 2259-2269 (2020)
The three-dimensional (3D) genome organization and its role in biological activities have been investigated for over a decade in the field of cell biology. Recent studies using live-imaging and polymer simulation have suggested that the higher-order
Externí odkaz:
https://doaj.org/article/243e88ba678243dbbd3db2a1819e0d1f
Publikováno v:
Nucleus, Vol 8, Iss 4, Pp 353-359 (2017)
The genome is 3-dimensionally organized in the cell, and the mammalian genome DNA is partitioned into submegabase-sized chromatin domains. Genome functions are regulated within and across the domains according to their organization, whereas the chrom
Externí odkaz:
https://doaj.org/article/5b9164e019564798a5374c07841feb49
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 10, p e1005136 (2016)
The mammalian genome is organized into submegabase-sized chromatin domains (CDs) including topologically associating domains, which have been identified using chromosome conformation capture-based methods. Single-nucleosome imaging in living mammalia
Externí odkaz:
https://doaj.org/article/62b7bda6e5934a578fbd09054e734f2a
Autor:
Tadasu Nozaki, Soya Shinkai, Satoru Ide, Koichi Higashi, Sachiko Tamura, Masa A. Shimazoe, Masaki Nakagawa, Yutaka Suzuki, Yasushi Okada, Masaki Sasai, Shuichi Onami, Ken Kurokawa, Shiori Iida, Kazuhiro Maeshima
Publikováno v:
Science Advances. 9
In eukaryotes, higher-order chromatin organization is spatiotemporally regulated as domains, for various cellular functions. However, their physical nature in living cells remains unclear (e.g., condensed domains or extended fiber loops; liquid-like
Autor:
Masatoshi Hara, Mariko Ariyoshi, Tomoki Sano, Ryu-suke Nozawa, Soya Shinkai, Shuichi Onami, Isabelle Jansen, Toru Hirota, Tatsuo Fukagawa
SummaryThe kinetochore is an essential protein complex for accurate chromosome segregation. The constitutive centromere-associated network (CCAN), a subcomplex of the kinetochore, associates with centromeric chromatin providing a platform for the kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3e88bc15928f553d8cd96cb25c39906
https://doi.org/10.1101/2022.08.17.504347
https://doi.org/10.1101/2022.08.17.504347
Autor:
Kazuko Okamoto, Hideaki Fujita, Yasushi Okada, Soya Shinkai, Shuichi Onami, Kuniya Abe, Kenta Fujimoto, Tomonobu M Watanabe
Nanog and Oct4 are core transcription factors in a gene regulatory network that regulate hundreds of target genes for pluripotency maintenance in mouse embryonic stem cells. To understand their function as a gatekeeper or a pioneer factor at the mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ad796b3720e5934f3c5ce92176f74d1
https://doi.org/10.1101/2022.08.08.503148
https://doi.org/10.1101/2022.08.08.503148
Autor:
Shiori Iida, Soya Shinkai, Yuji Itoh, Sachiko Tamura, Masato T. Kanemaki, Shuichi Onami, Kazuhiro Maeshima
Publikováno v:
Science Advances. 8
Dynamic chromatin behavior plays a critical role in various genome functions. However, it remains unclear how chromatin behavior changes during interphase, where the nucleus enlarges and genomic DNA doubles. While the previously reported chromatin mo
Summary High-throughput chromosome conformation capture (Hi-C) is a widely used assay for studying the three-dimensional (3D) genome organization across the whole genome. Here, we present PHi-C2, a Python package supported by mathematical and biophys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17d1839d30c3cca9d72600d7dbe2b0f6
https://doi.org/10.1101/2022.05.06.490994
https://doi.org/10.1101/2022.05.06.490994
Autor:
Soya Shinkai
Publikováno v:
Seibutsu Butsuri. 61:293-297
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 2259-2269 (2020)
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 2259-2269 (2020)
The three-dimensional (3D) genome organization and its role in biological activities have been investigated for over a decade in the field of cell biology. Recent studies using live-imaging and polymer simulation have suggested that the higher-order