Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Sowmya Pattabhi"'
Autor:
Sowmya Pattabhi, Samantha N. Lotti, Mason P. Berger, Swati Singh, Christopher T. Lux, Kyle Jacoby, Calvin Lee, Olivier Negre, Andrew M. Scharenberg, David J. Rawlings
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 17, Iss , Pp 277-288 (2019)
Gene editing following designer nuclease cleavage in the presence of a DNA donor template can revert mutations in disease-causing genes. For optimal benefit, reversion of the point mutation in HBB leading to sickle cell disease (SCD) would permit pre
Externí odkaz:
https://doaj.org/article/5c5d0cc4529c44adb9273c8f4a9f26d9
Autor:
Christopher T. Lux, Sowmya Pattabhi, Mason Berger, Cynthia Nourigat, David A. Flowers, Olivier Negre, Olivier Humbert, Julia G. Yang, Calvin Lee, Kyle Jacoby, Irwin Bernstein, Hans-Peter Kiem, Andrew Scharenberg, David J. Rawlings
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 12, Iss , Pp 175-183 (2019)
Elements within the γ-hemoglobin promoters (HBG1 and HBG2) function to bind transcription complexes that mediate repression of fetal hemoglobin expression. Sickle cell disease (SCD) subjects with a 13-bp deletion in the HBG1 promoter exhibit a clini
Externí odkaz:
https://doaj.org/article/d1669924b97e44a4beafad9d2ebc6f23
Autor:
Sowmya Pattabhi, Jacqueline Whittle, Raodoh Mohamath, Sayda El-Safi, Garner G Moulton, Jeffrey A Guderian, Danny Colombara, Asem O Abdoon, Maowia M Mukhtar, Dinesh Mondal, Javan Esfandiari, Shailendra Kumar, Peter Chun, Steven G Reed, Ajay Bhatia
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 4, Iss 9, p e1000888 (2010)
BACKGROUND: Visceral leishmaniasis (VL) is diagnosed by microscopic confirmation of the parasite in bone marrow, spleen or lymph node aspirates. These procedures are unsuitable for rapid diagnosis of VL in field settings. The development of rK39-base
Externí odkaz:
https://doaj.org/article/01b33bf8080e46989b7cabc842a4dedf
Autor:
David J. Rawlings, Samantha N. Lotti, Olivier Negre, Kyle Jacoby, Swati Singh, Sowmya Pattabhi, Andrew M. Scharenberg, Calvin Lee, Christopher T. Lux, Mason P. Berger
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 17, Iss, Pp 277-288 (2019)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
Gene editing following designer nuclease cleavage in the presence of a DNA donor template can revert mutations in disease-causing genes. For optimal benefit, reversion of the point mutation in HBB leading to sickle cell disease (SCD) would permit pre
Publikováno v:
J Interferon Cytokine Res
RNA helicases play an important role in the response to microbial infection. Retinoic acid inducible gene-I (RIG-I) and members of the RIG-I-like receptor (RLR) family of helicases function as cytoplasmic pattern recognition receptors (PRRs) whose ac
Autor:
Irwin D. Bernstein, Julia G. Yang, Andrew M. Scharenberg, Christopher T. Lux, Olivier Negre, Sowmya Pattabhi, David A. Flowers, Kyle Jacoby, Mason P. Berger, Hans-Peter Kiem, Calvin Lee, Cynthia Nourigat, Olivier Humbert, David J. Rawlings
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 12, Iss, Pp 175-183 (2019)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Elements within the γ-hemoglobin promoters (HBG1 and HBG2) function to bind transcription complexes that mediate repression of fetal hemoglobin expression. Sickle cell disease (SCD) subjects with a 13-bp deletion in the HBG1 promoter exhibit a clini
Autor:
Olivier Negre, Christopher W. Peterson, Christopher T. Lux, Sowmya Reddy, Ray R. Carrillo, Clare Samuelson, Anai M. Perez, Sowmya Pattabhi, Stefan Radtke, Ciaran M. Lee, David J. Rawlings, Jennifer E. Adair, Gang Bao, Lauren E Schefter, Olivier Humbert, Hans-Peter Kiem, Andrew M. Scharenberg
Publikováno v:
Sci Transl Med
Reactivation of fetal hemoglobin (HbF) is being pursued as a treatment strategy for hemoglobinopathies. Here, we evaluated the therapeutic potential of hematopoietic stem and progenitor cells (HSPCs) edited with the CRISPR/Cas9 nuclease platform to r
Publikováno v:
Genomics Data, Vol 7, Iss, Pp 290-292 (2016)
Genomics Data
Genomics Data
The recognition of pathogen associated molecular patterns (PAMPs) by pattern recognition receptors (PRR) during viral infection initiates the induction of antiviral signaling pathways, including activation of the Interferon Regulator Factor 3 (IRF3).
Autor:
Christopher W. Peterson, Ciaran M. Lee, Olivier Negre, Christopher T. Lux, David J. Rawlings, Gang Bao, Anai M. Perez, Lauren E Schefter, Hans-Peter Kiem, Sowmya Reddy, Ray R. Carillo, Olivier Humbert, Andrew M. Scharenberg, Stefan Radtke, Jennifer E. Adair, Sowmya Pattabhi
Publikováno v:
Blood. 132:806-806
Beta-thalassemia and sickle cell disease are monogenic disorders that are currently treated by allogeneic bone marrow (BM) transplantation although the challenges of finding a suitable matched-donor and the risk of graft vs host disease have limited
Autor:
Yeuk Mui Lee, Maria Silva-Ibanez, Sukwan Handali, Hector H. Garcia, Armando E. Gonzalez, Robert H. Gilman, Sowmya Pattabhi, Victor Kovalenko, Kathy Hancock, Andrew E. Levin, Jacquelin M. Roberts, Victor C. W. Tsang
Publikováno v:
Journal of Immunoassay and Immunochemistry. 31:60-70
We evaluated three diagnostic antigens (recombinant GP50, recombinant T24H, and synthetic Ts18var1) for cysticercosis and found that all three performed well in detecting cysticercosis in humans and pigs in several assay formats. These antigens were