Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sowmya Ajay Castro"'
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/bdbab7c17a374055a88b58145c65fe70
Publikováno v:
Royal Society Open Science, Vol 8, Iss 3 (2021)
Streptococcus pyogenes, also known as Group A Streptococcus (GAS), is a Gram-positive human-exclusive pathogen, responsible for more than 500 000 deaths annually worldwide. Upon infection, GAS commonly triggers mild symptoms such as pharyngitis, pyod
Externí odkaz:
https://doaj.org/article/79af20cd4cd843fd84690e4287e335de
Autor:
Daniel C. Nelson, Sowmya Ajay Castro, Helge C. Dorfmueller, Harley King, Amol Arunrao Pohane, Natalia Korotkova, C. M. Scholte, Vincent A. Fischetti
Publikováno v:
Biochem J
Endolysins are peptidoglycan (PG) hydrolases that function as part of the bacteriophage (phage) lytic system to release progeny phage at the end of a replication cycle. Notably, endolysins alone can produce lysis without phage infection, which offers
Autor:
Jeffrey S. Rush, Nina M. van Sorge, Andrew B. Herr, Sowmya Ajay Castro, Natalia Korotkova, Svetlana Zamakhaeva, Cameron W. Kenner, Gregory I. Frolenkov, Alexander E. Yarawsky, Konstantin V. Korotkov, Helge C. Dorfmueller, Catherine T. Chaton
Publikováno v:
Nat Chem Biol
Nature chemical biology, 17(8), 878-887. Nature Publishing Group
Nature chemical biology, 17(8), 878-887. Nature Publishing Group
In ovoid-shaped, Gram-positive bacteria, MapZ guides FtsZ-ring positioning at cell equators. The cell wall of the ovococcus Streptococcus mutans contains peptidoglycan decorated with serotype c carbohydrates (SCCs). In the present study, we identify
Autor:
Jennifer Cable, Rino Rappuoli, Elizabeth J. Klemm, Gagandeep Kang, Ankur Mutreja, Gavin J. Wright, Mariagrazia Pizza, Sowmya Ajay Castro, Joseph P. Hoffmann, Galit Alter, Andrea Carfi, Andrew J. Pollard, Florian Krammer, Ravindra K. Gupta, Caroline E. Wagner, Viviane Machado, Kayvon Modjarrad, Lawrence Corey, Peter B. Gilbert, Gordon Dougan, Nicole Lurie, Pamela J. Bjorkman, Christopher Chiu, Elisa Nemes, Stephen B. Gordon, Andrew C. Steer, Thomas Rudel, Catherine A. Blish, John Tyler Sandberg, Kiva Brennan, Keith P. Klugman, Lynda M. Stuart, Shabir A. Madhi, Christopher L. Karp
Publikováno v:
Annals of the New York Academy of Sciences
The rapid development of COVID-19 vaccines was the result of decades of research to establish flexible vaccine platforms and understand pathogens with pandemic potential, as well as several novel changes to the vaccine discovery and development proce
Autor:
Benjamin H. Meyer, Azul Zorzoli, Sarah Thomson, Mark Reglinski, Helge C. Dorfmueller, Sowmya Ajay Castro
BackgroundGroup A Streptococcus (GAS) are responsible for a wide range of human-exclusive infections, annually killing more than 500,000 people. Antibiotic resistance incidence of invasive GAS tripled in the past decade and emphasises the need to dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71448008507b87f2127431eac655bd3b
https://doi.org/10.1101/2021.11.12.468441
https://doi.org/10.1101/2021.11.12.468441
Roadmap shows four vital preferred product characteristics to build a universal GAS vaccine. The future GAS vaccine should consider to include 1) a wide coverage of GAS strains and serotypes by building a multicomponent vaccines 2) and test the effic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b4eb1133cc8911d9aaee2cc396e626a
Autor:
Jeffrey S. Rush, Sowmya Ajay Castro, Konstantin V. Korotkov, Helge C. Dorfmueller, Nina M. van Sorge, Catherine T. Chaton, Andrew B. Herr, Gregory I. Frolenkov, Svetlana Zamakhaeva, Natalia Korotkova, Alexander E. Yarawsky
Bacterial cell division is driven by a tubulin homolog FtsZ, which assembles into the Z-ring structure leading to the recruitment of the cell division machinery. In ovoid-shaped Gram-positive bacteria, such as streptococci, MapZ guides Z-ring positio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70bbee149dd71c2ceef115771331a313
https://doi.org/10.1101/2020.06.26.173716
https://doi.org/10.1101/2020.06.26.173716