Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Sowmya, Iyer"'
Autor:
Gaylor Boulay, Liliane C. Broye, Rui Dong, Sowmya Iyer, Rajendran Sanalkumar, Yu-Hang Xing, Rémi Buisson, Shruthi Rengarajan, Beverly Naigles, Benoît Duc, Angela Volorio, Mary E. Awad, Raffaele Renella, Ivan Chebib, G. Petur Nielsen, Edwin Choy, Gregory M. Cote, Lee Zou, Igor Letovanec, Ivan Stamenkovic, Miguel N. Rivera, Nicolò Riggi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract EWS fusion oncoproteins underlie several human malignancies including Desmoplastic Small Round Cell Tumor (DSRCT), an aggressive cancer driven by EWS-WT1 fusion proteins. Here we combine chromatin occupancy and 3D profiles to identify EWS-WT
Externí odkaz:
https://doaj.org/article/fd00253648764577aeb52739a580a6a3
Autor:
Lisa N. Kasiewicz, Souvik Biswas, Aaron Beach, Huilan Ren, Chaitali Dutta, Anne Marie Mazzola, Ellen Rohde, Alexandra Chadwick, Christopher Cheng, Sara P. Garcia, Sowmya Iyer, Yuri Matsumoto, Amit V. Khera, Kiran Musunuru, Sekar Kathiresan, Padma Malyala, Kallanthottathil G. Rajeev, Andrew M. Bellinger
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Lipid nanoparticles have demonstrated utility in hepatic delivery of a range of therapeutic modalities and typically deliver their cargo via low-density lipoprotein receptor-mediated endocytosis. For patients lacking sufficient low-density l
Externí odkaz:
https://doaj.org/article/3005b2e0a2d6495d964d5dc6d482dff2
Autor:
Emely Möller, Viviane Praz, Sanalkumar Rajendran, Rui Dong, Alexandra Cauderay, Yu-Hang Xing, Lukuo Lee, Carlo Fusco, Liliane C. Broye, Luisa Cironi, Sowmya Iyer, Shruthi Rengarajan, Mary E. Awad, Beverly Naigles, Igor Letovanec, Nicola Ormas, Giovanna Finzi, Stefano La Rosa, Fausto Sessa, Ivan Chebib, G. Petur Nielsen, Antonia Digklia, Dimitrios Spentzos, Gregory M. Cote, Edwin Choy, Martin Aryee, Ivan Stamenkovic, Gaylor Boulay, Miguel N. Rivera, Nicolò Riggi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The relationship between cellular histogenesis and molecular phenotypes for the EWSR1- ATF1 fusion in clear cell sarcoma (CCS) requires further characterization. Here, the authors investigate the EWSR1-ATF1 gene regulation networks in CCS cell lines,
Externí odkaz:
https://doaj.org/article/1755fdc1556a4ae2aea83d025041fcd5
Autor:
Y. Esther Tak, Gaylor Boulay, Lukuo Lee, Sowmya Iyer, Nicholas T. Perry, Hayley T. Schultz, Sara P. Garcia, Liliane Broye, Joy E. Horng, Shruthi Rengarajan, Beverly Naigles, Angela Volorio, Jeffry D. Sander, Jingyi Gong, Nicolò Riggi, J. Keith Joung, Miguel N. Rivera
Publikováno v:
Cell Genomics, Vol 2, Iss 4, Pp 100119- (2022)
Summary: Repeat elements can be dysregulated at a genome-wide scale in human diseases. For example, in Ewing sarcoma, hundreds of inert GGAA repeats can be converted into active enhancers when bound by EWS-FLI1. Here we show that fusions between EWS
Externí odkaz:
https://doaj.org/article/95b2c278cc204064b4d31361085de605
Autor:
Divy Kangeyan, Andrew Dunford, Sowmya Iyer, Chip Stewart, Megan Hanna, Gad Getz, Martin J. Aryee
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-5 (2019)
Abstract Background Bisulfite sequencing allows base-pair resolution profiling of DNA methylation and has recently been adapted for use in single-cells. Analyzing these data, including making comparisons with existing data, remains challenging due to
Externí odkaz:
https://doaj.org/article/1bf9869603ee4e8b8a6fa853f184185e
Autor:
Sowmya Iyer, Priyanka Mehta, Christine E. Gould, Sirisha Gara, Marisa-Francesca B. Brodrick, J. Lisa Tenover
Publikováno v:
Clinical Gerontologist. :1-8
Autor:
Sowmya Iyer, Priyanka Mehta, Joanne Weith, Dat Hoang-Gia, Janet Moore, Chalise Carlson, Philip Choe, Erin Sakai, Christine Gould
Publikováno v:
Journal of Primary Care & Community Health, Vol 12 (2021)
Background: To characterize the experience of converting a geriatrics clinic to telehealth visits in early stages of a pandemic. Design: An organizational case study with mixed methods evaluation from the first 8 weeks of converting a geriatrics clin
Externí odkaz:
https://doaj.org/article/bab3fb1a501847168ec38f56c59fc89e
Autor:
Rajendran Sanalkumar, Rui Dong, Lukuo Lee, Yu-Hang Xing, Sowmya Iyer, Igor Letovanec, Stefano La Rosa, Giovanna Finzi, Elettra Musolino, Roberto Papait, Ivan Chebib, G. Petur Nielsen, Raffaele Renella, Gregory M. Cote, Edwin Choy, Martin Aryee, Kimberly Stegmaier, Ivan Stamenkovic, Miguel N. Rivera, Nicolò Riggi
Publikováno v:
Science advances, vol. 9, no. 13, pp. eabo3789
Cell fate transitions observed in embryonic development involve changes in three-dimensional genomic organization that provide proper lineage specification. Whether similar events occur within tumor cells and contribute to cancer evolution remains la
Autor:
Christine E. Gould, Sowmya Iyer, Julie Filips, Ana Jessica Alfaro, Chalise Carlson, Ranak Trivedi
Publikováno v:
Journal of Technology in Behavioral Science.
Older patients with cognitive impairment, including dementia, may benefit from virtual care that increases access to geriatric specialties. Here, we identify clinician-level strategies to address the numerous barriers that reduce utilization of virtu
Autor:
Kallanthottathil G. Rajeev, Nicole M. Gaudelli, Yusuf S. Nasrullah, Soumyashree A. Gangopadhyay, Andrew M. Bellinger, Sara P. Garcia, James Madsen, Jamie E. DeNizio, Athul Sanjeev, Lisa N. Kasiewicz, Giuseppe Ciaramella, Aaron Beach, Ellen Rohde, Anne Marie Mazzola, Thomas V. Colace, Kui Wang, Sowmya Iyer, Caroline W. Reiss, Padma Malyala, Steven H. Y. Fan, Victoria Clendaniel, Christopher J. Cheng, Jennifer Lavoie, Taiji Mizoguchi, Yuri Matsumoto, Madeleine Shay, Kiran Musunuru, Leslie E. Stolz, Maurine C. Braun, Chaitali Dutta, Ying K. Tam, Joseph Nneji, Ryan Garrity, Alexandra C. Chadwick, Souvik Biswas, Michael Amaonye, John D. Ganey, Mary R. Stahley, Huilan Ren, Huei-Mei Chen, Kathleen Berth, Sekar Kathiresan
Publikováno v:
Nature. 593:429-434
Gene-editing technologies, which include the CRISPR–Cas nucleases1–3 and CRISPR base editors4,5, have the potential to permanently modify disease-causing genes in patients6. The demonstration of durable editing in target organs of nonhuman primat