Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sowmiya Palani"'
Autor:
Sowmiya Palani, Yuka Machida, Julia R. Alvey, Vandana Mishra, Allison L. Welter, Gaofeng Cui, Benoît Bragantini, Maria Victoria Botuyan, Anh T. Q. Cong, Georges Mer, Matthew J. Schellenberg, Yuichi J. Machida
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract FAM111A, a serine protease, plays roles in DNA replication and antiviral defense. Missense mutations in the catalytic domain cause hyper-autocleavage and are associated with genetic disorders with developmental defects. Despite the enzyme’
Externí odkaz:
https://doaj.org/article/04b6d5d1449d4892b6e3d297c8272f1f
Autor:
Yusuke Kojima, Yuka Machida, Sowmiya Palani, Thomas R. Caulfield, Evette S. Radisky, Scott H. Kaufmann, Yuichi J. Machida
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
DNA-protein crosslinks represent obstacles on genomic DNA that can hamper progression of replication forks. Here, the authors reveal that FAM111A, a PCNA-interacting protein, plays part in mitigating the effect of protein obstacles on replication for
Externí odkaz:
https://doaj.org/article/e9822e13f0724bd0b06193f6b527c895
Autor:
Saravanan Ramakrishnan, Srijana Pokhrel, Sowmiya Palani, Christian Pflueger, Timothy J. Parnell, Bradley R. Cairns, Srividya Bhaskara, Mahesh B. Chandrasekharan
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Histone H3K4 methylation affects gene transcription from yeast to humans. Here, the authors show that Set1 and Jhd2, the only H3K4 methyltransferase and H3K4 demethylase, respectively, in budding yeast, co-regulate both positive and negative transcri
Externí odkaz:
https://doaj.org/article/c625e8ba26fc4e15b485691b7990fe44
Autor:
Matthew A Sdano, James M Fulcher, Sowmiya Palani, Mahesh B Chandrasekharan, Timothy J Parnell, Frank G Whitby, Tim Formosa, Christopher P Hill
Publikováno v:
eLife, Vol 6 (2017)
We determined that the tandem SH2 domain of S. cerevisiae Spt6 binds the linker region of the RNA polymerase II subunit Rpb1 rather than the expected sites in its heptad repeat domain. The 4 nM binding affinity requires phosphorylation at Rpb1 S1493
Externí odkaz:
https://doaj.org/article/e18ab755fcdb496192364c8e719f794e
Autor:
Prakash K Shukla, Jesse E Bissell, Sanjit Kumar, Srijana Pokhrel, Sowmiya Palani, Kaitlin S Radmall, Onyeka Obidi, Timothy J Parnell, Julia Brasch, Dennis C Shrieve, Mahesh B Chandrasekharan
Publikováno v:
Nucleic Acids Research. 51:2117-2136
The conserved complex of the Rad6 E2 ubiquitin-conjugating enzyme and the Bre1 E3 ubiquitin ligase catalyzes histone H2B monoubiquitination (H2Bub1), which regulates chromatin dynamics during transcription and other nuclear processes. Here, we report
Autor:
Scott H. Kaufmann, Thomas R. Caulfield, Sowmiya Palani, Yuka Machida, Yuichi J. Machida, Evette S. Radisky, Yusuke Kojima
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Persistent protein obstacles on genomic DNA, such as DNA-protein crosslinks (DPCs) and tight nucleoprotein complexes, can block replication forks. DPCs can be removed by the proteolytic activities of the metalloprotease SPRTN or the proteasome in a r
Autor:
Christopher P. Hill, Timothy J. Parnell, Sowmiya Palani, Frank G. Whitby, James M Fulcher, Tim Formosa, Matthew A. Sdano, Mahesh B. Chandrasekharan
Publikováno v:
eLife, Vol 6 (2017)
eLife
eLife
We determined that the tandem SH2 domain of S. cerevisiae Spt6 binds the linker region of the RNA polymerase II subunit Rpb1 rather than the expected sites in its heptad repeat domain. The 4 nM binding affinity requires phosphorylation at Rpb1 S1493
Autor:
Christopher P. Hill, Timothy J. Parnell, Tim Formosa, Frank G. Whitby, James M Fulcher, Matthew A. Sdano, Sowmiya Palani, Mahesh B. Chandrasekharan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1ed5fe14bc60860f432717611aa25cd
https://doi.org/10.7554/elife.28723.033
https://doi.org/10.7554/elife.28723.033
Two-dimensional (2D) nanomaterials are an emerging class of materials with unique physical and chemical properties due to their high surface area and disc-like shape. Recently, these 2D nanomaterials have been investigated for a range of biomedical a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f3529202a68bc6c3493dd8dc737b7a7
https://europepmc.org/articles/PMC5702597/
https://europepmc.org/articles/PMC5702597/
Autor:
Srijana Pokhrel, Saravanan Ramakrishnan, Timothy J. Parnell, Bradley R. Cairns, Sowmiya Palani, Mahesh B. Chandrasekharan, Christian Pflueger, Srividya Bhaskara
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Histone H3K4 methylation is connected to gene transcription from yeast to humans, but its mechanistic roles in transcription and chromatin dynamics remain poorly understood. We investigated the functions for Set1 and Jhd2, the sole H3K4 methyltransfe