Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Sowjanya Polepalli"'
Publikováno v:
Letters in Drug Design & Discovery. 16:846-860
Background: In an effort to establish new drug candidates with improved antiproliferative activity, we report here a novel class of compounds designed rationally by the replacement of an ethyl group in tamoxifen with a methylene (1H-1,2,4-triazole) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b5ff8a077ea3f1a103b4e7efd8cac1c
https://doi.org/10.2174/1570180815666180621100314
https://doi.org/10.2174/1570180815666180621100314
Autor:
Saleha Banu, Rajitha Bollu, Nishant Jain, Lingaiah Nagarapu, Rajashaker Bantu, Suresh Kasaboina, Sowjanya Polepalli
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:5481-5484
A novel synthetic protocol has been developed for the synthesis of 1,4-benzoxazinone-acetylphenylallyl quinazolin-4(3H)-one hybrids 7a–n by employing Pd-catalyzed C H arylation in presence of 5–10% phosphine ligand in good to excellent yields and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daef2909fdb484249e57deab8087556b
https://doi.org/10.1016/j.bmcl.2017.10.044
https://doi.org/10.1016/j.bmcl.2017.10.044
Autor:
Nishant Jain, Sowjanya Polepalli, Sudheer Kumar Buddana, Srujana Garimella, Jagadeesh Babu Nanubolu, M. S. R. Murty, Mohana Rao Katiki, Reddy Shetty Prakasham
Publikováno v:
Molecular Diversity. 20:687-703
A new class of compounds, structurally related to the breast cancer drug tamoxifen, was designed and synthesized. The McMurry coupling reaction was used as the key synthetic step in the preparation of these analogs, and the structural assignments wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f37d96a0a7fc2c832ae19a8342f1e70a
https://doi.org/10.1007/s11030-016-9677-8
https://doi.org/10.1007/s11030-016-9677-8
Publikováno v:
Medicinal Chemistry Research. 25:627-643
A novel class of resveratrol-oxadiazole hybrid compounds was synthesized to screen for their in vitro antiproliferative activity against three human cancer cell lines. All the compounds showed superior antiproliferative activity than the reference co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60a6d7f60e638634245c93bc3b6b3c1a
https://doi.org/10.1007/s00044-016-1514-1
https://doi.org/10.1007/s00044-016-1514-1
Publikováno v:
Indian Journal of Pharmaceutical Sciences. 80
A series of 1-substituted-1H-tetrazole-5-thiol building blocks were synthesized (6a–h) and coupled by S-alkylation with 2-bromo-1-(4-(substituted phenylsulfonyl)piperazin-1-yl)ethanone (4a–c) using triethylamine in ethanol under reflux conditions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac8844693637a9fc18c15538208f3e07
https://doi.org/10.4172/pharmaceutical-sciences.1000440
https://doi.org/10.4172/pharmaceutical-sciences.1000440
Autor:
Vangala Santhosh Reddy, Anver Basha Shaik, Nishant Jain, G. Bharath Kumar, M.V.P.S. Vishnuvardhan, Ahmed Kamal, Sowjanya Polepalli
Publikováno v:
Organic & Biomolecular Chemistry. 13:3416-3431
A new class of pyrazole and isoxazole conjugates were synthesized and evaluated for their cytotoxic activity against various human cancer cell lines. These compounds have shown significant cytotoxicity with lower IC50 values. FACS results revealed th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc29e492f1455b8efc416278f991e55a
https://doi.org/10.1039/c4ob02449d
https://doi.org/10.1039/c4ob02449d
Autor:
Nishant Jain, Chandrakant Bagul, Sowjanya Polepalli, A. Subba Rao, Siddiq Pasha Shaik, Ahmed Kamal, T. Srinivasa Reddy, M.V.P.S. Vishnuvardhan
Publikováno v:
MedChemComm. 6:1842-1856
Two series of 2-ethyl-6-(3′,4′,5′-trimethoxyphenyl)-5-aryl and 2-cyclopropyl-6-(3′,4′,5′-trimethoxyphenyl)-5-aryl-imidazothiadiazoles were designed, synthesized and evaluated for anti-proliferative activity in various human cancer cell li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a11ad3efb72390f5dbeebc4607879a18
https://doi.org/10.1039/c5md00155b
https://doi.org/10.1039/c5md00155b
Autor:
Kommula Dileep, M. S. R. Murty, Sowjanya Polepalli, Nishant Jain, Sudheer Kumar Buddana, Reddy Shetty Prakasham
Publikováno v:
Molecular diversity. 22(1)
A series of 1-substituted-1H-tetrazole-5-thiol building blocks were synthesized and introduced to the N-4 piperazinyl group at C-7 position of the quinolone core, and these novel compounds (5a–g and 8a–g) were screened for their antibacterial and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae58a8feeae033cd4e37df93d0d4a46
https://pubmed.ncbi.nlm.nih.gov/29138963
https://pubmed.ncbi.nlm.nih.gov/29138963
Autor:
Ahmed Kamal, Nagula Shankaraiah, Nishant Jain, T. Srinivasa Reddy, Nekkanti Shalini, Sowjanya Polepalli, V. Ganga Reddy, A. Subba Rao
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:5466-5475
A series of new podophyllotoxin derivatives containing structural modifications at C-7, C-8, and C-9 were synthesized and evaluated for their cytotoxic activity against three human cancer cell lines. All the synthesized compounds showed significant g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bb3aefcd6158a67e1fac249f5a74f35
https://doi.org/10.1016/j.bmc.2014.07.031
https://doi.org/10.1016/j.bmc.2014.07.031
Autor:
M. S. R. Murty, Nishant Jain, Pompi Das, Raju Penthala, Sudheer Kumar Buddana, Sowjanya Polepalli, Reddy Shetty Prakasham, Sreedhar Bojja
Publikováno v:
Medicinal Chemistry Research. 23:4579-4594
A series of new 2,5-disubstituted 1,3,4-oxadiazoles have been conveniently synthesized through an oxidative C–O coupling by direct C–H bond activation of N-aroyl-N-arylidinehydrazines using a catalytic quantity of CuO nanoparticles. Twenty compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e7439fbf337b8c834332a7b86846b85
https://doi.org/10.1007/s00044-014-1025-x
https://doi.org/10.1007/s00044-014-1025-x