Optical method to determine in vivo capillary hematocrit, hemoglobin concentration, and 3-D network geometry in skeletal muscle.

Autor: Christie JR; Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada., Kong I; Division of Radiation Oncology, Department of Oncology, Juravinski Cancer Centre, McMaster University, Hamilton, Ontario, Canada., Mawdsley L; Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada.; Robarts Research Institute, University of Western Ontario, London, Ontario, Canada., Milkovich S; Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada.; Robarts Research Institute, University of Western Ontario, London, Ontario, Canada., Doornekamp A; Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada., Baek J; Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Fraser GM; Division of BioMedical Sciences, Memorial University of Newfoundland, St. John's, NL, Canada., Ellis CG; Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada.; Robarts Research Institute, University of Western Ontario, London, Ontario, Canada., Sové RJ; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.

Publikováno v: Microcirculation (New York, N.Y. : 1994) [Microcirculation] 2022 Oct; Vol. 29 (6-7), pp. e12751. Date of Electronic Publication: 2022 Feb 22.

Spectroscopy detects skeletal muscle microvascular dysfunction during onset of sepsis in a rat fecal peritonitis model.

Autor: Kowalewska PM; Department of Medical Biophysics, University of Western Ontario, London, ON, Canada., Kowalewski JE; Department of Psychiatry, University of Western Ontario, London, ON, Canada., Milkovich SL; Department of Medical Biophysics, University of Western Ontario, London, ON, Canada., Sové RJ; Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA., Wang L; Department of Anatomy and Cell Biology, University of Western Ontario, London, ON, Canada., Whitehead SN; Department of Anatomy and Cell Biology, University of Western Ontario, London, ON, Canada., Ellis CG; Department of Medical Biophysics, University of Western Ontario, London, ON, Canada. cgellis@uwo.ca.

Publikováno v: Scientific reports [Sci Rep] 2022 Apr 15; Vol. 12 (1), pp. 6339. Date of Electronic Publication: 2022 Apr 15.

Localized Oxygen Exchange Platform for Intravital Video Microscopy Investigations of Microvascular Oxygen Regulation.

Autor: Sové RJ; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Milkovich S; Department of Medical Biophysics, University of Western Ontario, London, ON, Canada., Nikolov HN; Robarts Research Institute, University of Western Ontario, London, ON, Canada., Holdsworth DW; Department of Medical Biophysics, University of Western Ontario, London, ON, Canada.; Robarts Research Institute, University of Western Ontario, London, ON, Canada., Ellis CG; Department of Medical Biophysics, University of Western Ontario, London, ON, Canada., Fraser GM; Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.

Publikováno v: Frontiers in physiology [Front Physiol] 2021 Jun 08; Vol. 12, pp. 654928. Date of Electronic Publication: 2021 Jun 08 (Print Publication: 2021).

A data-driven computational model enables integrative and mechanistic characterization of dynamic macrophage polarization.

Autor: Zhao C; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, 613 Traylor Bldg, Baltimore, MD 21205, USA., Medeiros TX; Department of Medicine, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA., Sové RJ; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, 613 Traylor Bldg, Baltimore, MD 21205, USA., Annex BH; Department of Medicine, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA., Popel AS; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, 613 Traylor Bldg, Baltimore, MD 21205, USA.

Publikováno v: IScience [iScience] 2021 Jan 29; Vol. 24 (2), pp. 102112. Date of Electronic Publication: 2021 Jan 29 (Print Publication: 2021).

Combination therapy with T cell engager and PD-L1 blockade enhances the antitumor potency of T cells as predicted by a QSP model.

Autor: Ma H; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA hma24@jhmi.edu., Wang H; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Sové RJ; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Wang J; Biotherapeutics Discovery Research, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, Connecticut, USA., Giragossian C; Biotherapeutics Discovery Research, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, Connecticut, USA., Popel AS; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Oncology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine, Baltimore, Maryland, USA.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2020 Aug; Vol. 8 (2).