Synthesis, Characterization and in vitro, in vivo and in silico Anti-Inflammatory Studies of the Novel Hybrid Based on Ibuprofen and 3-Hydroxy-Copalic Acid Isolated from Copaiba Oil (Copaifera multijuga)

Autor: Souza,Fábio C. de, Brito,Larissa F., Silva,Marcos T., Sugimoto,Michelle A., Pinto,Ana Cristina S., Almeida,Patrícia D. O. de, Souza,Rodrigo O. S., Costa,Renyer A., Guilhon-Simplicio,Fernanda, Wanderley,Almir G., Oliveira,Kelson M. T. de, Sousa,Lirlândia P., Veiga-Junior,Valdir F. da, Lima,Emerson S.

Publikováno v: Journal of the Brazilian Chemical Society, Volume: 31, Issue: 7, Pages: 1335-1344, Published: 03 JUL 2020
Journal of the Brazilian Chemical Society v.31 n.7 2020
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ

A novel anti-inflammatory hybrid 3-ibuprofenyl-copalic acid (3-IbuCA) was synthesized from 3-hydroxy-copalic acid isolated from Amazonian copaiba oil (Copaifera multijuga Hayne), and the anti-inflammatory ibuprofen. After full characterization, sever

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532020000701335&lng=en&tlng=en

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