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Autor:
Bin Liu, Gary D. Lopaschuk, Thomas Arrhenius, Steven Brown, Charles Harmon, Rick L. Barr, David Wallace, Vicki Thorn, Jason R.B. Dyck, Jie-Fei Cheng, Souvothy Tith, Sean Reily, Mi Chen, Masayuki Haramura, Chi Ching Mak, Alex M. Nadzan
Publikováno v:
Journal of medicinal chemistry. 49(5)
The discovery and structure−activity relationship of first-generation small-molecule malonyl-CoA decarboxylase (MCD; CoA = coenzyme A) inhibitors are reported. We demonstrated that MCD inhibitors increased malonyl-CoA concentration in the isolated