Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting.

Autor: Huard K; Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Smith AC; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Cappon G; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Dow RL; Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Edmonds DJ; Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., El-Kattan A; Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Esler WP; Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Fernando DP; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Griffith DA; Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Kalgutkar AS; Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Ross TT; Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Bagley SW; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Beebe D; Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Bi YA; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Cabral S; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Crowley C; Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Doran SD; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Dowling MS; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Liras S; Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Mascitti V; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Niosi M; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Pfefferkorn JA; Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Polivkova J; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Préville C; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Price DA; Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Shavnya A; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Shirai N; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Smith AH; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Southers JR; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Tess DA; Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Thuma BA; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Varma MV; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Yang X; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2020 Oct 08; Vol. 63 (19), pp. 10879-10896. Date of Electronic Publication: 2020 Sep 18.