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Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.

Autor: Kung DW; Worldwide Medicinal Chemistry, Groton, CT 06340, United States. Electronic address: daniel.w.kung@pfizer.com., Griffith DA; Worldwide Medicinal Chemistry, Cambridge, MA 02139, United States. Electronic address: david.a.griffith@pfizer.com., Esler WP; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Cambridge, MA 02139, United States., Vajdos FF; Structural Biology, Groton, CT 06340, United States., Mathiowetz AM; Worldwide Medicinal Chemistry, Cambridge, MA 02139, United States., Doran SD; Pharmacokinetics, Dynamics and Metabolism, Groton, CT 06340, United States., Amor PA; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Cambridge, MA 02139, United States., Bagley SW; Worldwide Medicinal Chemistry, Groton, CT 06340, United States., Banks T; Worldwide Medicinal Chemistry, Groton, CT 06340, United States., Cabral S; Worldwide Medicinal Chemistry, Groton, CT 06340, United States., Ford K; Primary Pharmacology Group, Groton, CT 06340, United States., Garcia-Irizarry CN; Worldwide Medicinal Chemistry, Groton, CT 06340, United States., Landis MS; Pharmaceutical Sciences Research Formulations, Pfizer Worldwide Research and Development, Cambridge, MA 02139, United States., Loomis K; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Groton, CT 06340, United States., McPherson K; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Groton, CT 06340, United States., Niosi M; Pharmacokinetics, Dynamics and Metabolism, Groton, CT 06340, United States., Rockwell KL; Primary Pharmacology Group, Groton, CT 06340, United States., Rose C; Worldwide Medicinal Chemistry, Groton, CT 06340, United States., Smith AC; Worldwide Medicinal Chemistry, Groton, CT 06340, United States., Southers JA; Worldwide Medicinal Chemistry, Groton, CT 06340, United States., Tapley S; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Groton, CT 06340, United States., Tu M; Worldwide Medicinal Chemistry, Cambridge, MA 02139, United States., Valentine JJ; Primary Pharmacology Group, Groton, CT 06340, United States.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Nov 15; Vol. 25 (22), pp. 5352-6. Date of Electronic Publication: 2015 Sep 15.

Spirolactam-based acetyl-CoA carboxylase inhibitors: toward improved metabolic stability of a chromanone lead structure.

Autor: Griffith DA; Pfizer Worldwide Research and Development , Eastern Point Road, Groton, Connecticut 06340, United States., Dow RL, Huard K, Edmonds DJ, Bagley SW, Polivkova J, Zeng D, Garcia-Irizarry CN, Southers JA, Esler W, Amor P, Loomis K, McPherson K, Bahnck KB, Préville C, Banks T, Moore DE, Mathiowetz AM, Menhaji-Klotz E, Smith AC, Doran SD, Beebe DA, Dunn MF

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2013 Sep 12; Vol. 56 (17), pp. 7110-9. Date of Electronic Publication: 2013 Aug 27.

Synthesis of spiropiperidine lactam acetyl-CoA carboxylase inhibitors.

Autor: Huard K; Pfizer Worldwide Research & Development, Eastern Point Road, Groton, Connecticut 06340, USA., Bagley SW, Menhaji-Klotz E, Préville C, Southers JA Jr, Smith AC, Edmonds DJ, Lucas JC, Dunn MF, Allanson NM, Blaney EL, Garcia-Irizarry CN, Kohrt JT, Griffith DA, Dow RL

Publikováno v: The Journal of organic chemistry [J Org Chem] 2012 Nov 16; Vol. 77 (22), pp. 10050-7. Date of Electronic Publication: 2012 Nov 05.

Metabolism-guided design of short-acting calcium-sensing receptor antagonists.

Autor: Southers JA; Pfizer Global Research and Development, Groton, Connecticut 06340., Bauman JN; Pfizer Global Research and Development, Groton, Connecticut 06340., Price DA; Pfizer Global Research and Development, Groton, Connecticut 06340., Humphries PS; Pfizer Global Research and Development, Groton, Connecticut 06340., Balan G; Pfizer Global Research and Development, Groton, Connecticut 06340., Sagal JF; Pfizer Global Research and Development, Groton, Connecticut 06340., Maurer TS; Pfizer Global Research and Development, Groton, Connecticut 06340., Zhang Y; Pfizer Global Research and Development, Groton, Connecticut 06340., Oliver R; Pfizer Global Research and Development, Groton, Connecticut 06340., Herr M; Pfizer Global Research and Development, Groton, Connecticut 06340., Healy DR; Pfizer Global Research and Development, Groton, Connecticut 06340., Li M; Pfizer Global Research and Development, Groton, Connecticut 06340., Kapinos B; Pfizer Global Research and Development, Groton, Connecticut 06340., Fate GD; Pfizer Global Research and Development, Groton, Connecticut 06340., Riccardi KA; Pfizer Global Research and Development, Groton, Connecticut 06340., Paralkar VM; Pfizer Global Research and Development, Groton, Connecticut 06340., Brown TA; Pfizer Global Research and Development, Groton, Connecticut 06340., Kalgutkar AS; Pfizer Global Research and Development, Groton, Connecticut 06340.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2010 May 13; Vol. 1 (5), pp. 219-23. Date of Electronic Publication: 2010 May 13 (Print Publication: 2010).