FlyORF-TaDa allows rapid generation of new lines for in vivo cell-type specific profiling of protein-DNA interactions in Drosophila melanogaster

Autor: Aughey, GN, Delandre, C, Southall, TD, Marshall, OJ

Targeted DamID (TaDa) is an increasingly popular method of generating cell-type specific DNA binding profiles in vivo. Although sensitive and versatile, TaDa requires the generation of new transgenic fly lines for every protein that is profiled, whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::dacd0816bc937e68778cc328255eb0c6
http://hdl.handle.net/10044/1/81783

Dedifferentiation of neurons precedes tumor gormation in lola mutants

Autor: Southall, TD, Davidson, CM, Miller, C, Carr, A, Brand, AH

The ability to reprogram differentiated cells into a pluripotent state has revealed that the differentiated state is plastic and reversible. It is evident, therefore, that mechanisms must be in place to maintain cells in a differentiated state. Trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::13b92e4b5e1ef1adf8191f8994f5b51c
http://hdl.handle.net/10044/1/18088

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NuRD-independent Mi-2 activity represses ectopic gene expression during neuronal maturation.

Autor: Aughey GN; Department of Life Sciences, Imperial College London, London, UK., Forsberg E; Department of Life Sciences, Imperial College London, London, UK., Grimes K; Department of Life Sciences, Imperial College London, London, UK., Zhang S; Department of Life Sciences, Imperial College London, London, UK., Southall TD; Department of Life Sciences, Imperial College London, London, UK.

Publikováno v: EMBO reports [EMBO Rep] 2023 Apr 05; Vol. 24 (4), pp. e55362. Date of Electronic Publication: 2023 Feb 01.

Escargot controls somatic stem cell maintenance through the attenuation of the insulin receptor pathway in Drosophila.

Autor: Sênos Demarco R; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA., Stack BJ; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA., Tang AM; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA., Voog J; Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Sandall SL; Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Southall TD; Department of Life Sciences, Imperial College London, Sir Ernst Chain Building, London SW7 2AZ, UK., Brand AH; The Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 1QN, UK., Jones DL; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Anatomy, Division of Geriatrics, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Medicine, Division of Geriatrics, University of California, San Francisco, San Francisco, CA 94143, USA; Eli and Edythe Broad Center for Regeneration Medicine, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: leanne.jones@ucsf.edu.

Publikováno v: Cell reports [Cell Rep] 2022 Apr 19; Vol. 39 (3), pp. 110679.