Fragment-Based Screen of SARS-CoV-2 Papain-like Protease (PL ^pro ).

Autor: Taylor AJ; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Amporndanai K; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Rietz TA; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Zhao B; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Thiruvaipati A; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Wei Q; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., South TM; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Crow MM; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Apakama C; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Sensintaffar JL; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Phan J; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Lee T; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Fesik SW; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-6600, United States.; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2024 Jul 23; Vol. 15 (8), pp. 1351-1357. Date of Electronic Publication: 2024 Jul 23 (Print Publication: 2024).

Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models.

Autor: Teuscher KB; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146., Chowdhury S; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146., Meyers KM; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146., Tian J; Molecular Design and Synthesis Center, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232-0142., Sai J; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146., Van Meveren M; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146., South TM; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146., Sensintaffar JL; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146., Rietz TA; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146., Goswami S; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-0146., Wang J; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232-0004.; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN 37232-0004., Grieb BC; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-0146.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232-0011., Lorey SL; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-0146., Howard GC; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-0146., Liu Q; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232-0004.; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN 37232-0004., Moore WJ; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201., Stott GM; Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD 21701-4907., Tansey WP; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146.; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-0146., Lee T; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146., Fesik SW; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146.; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232-0146.; Department of Chemistry, Vanderbilt University, Nashville, TN 37232-0146.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Jan 03; Vol. 120 (1), pp. e2211297120. Date of Electronic Publication: 2022 Dec 27.

Using NMR Spectroscopy To Measure Protein Binding Capacity on Gold Nanoparticles.

Autor: Perera YR; Mississippi State University, Mississippi State, Mississippi., South TM; Mississippi State University, Mississippi State, Mississippi., Hughes AC; Mississippi State University, Mississippi State, Mississippi., Parkhurst AN; Mississippi State University, Mississippi State, Mississippi., Williams OC; Mississippi State University, Mississippi State, Mississippi., Davidson MB; Mississippi State University, Mississippi State, Mississippi., Wilks CA; Mississippi State University, Mississippi State, Mississippi., Mlsna DA; Mississippi State University, Mississippi State, Mississippi., Fitzkee NC; Mississippi State University, Mississippi State, Mississippi.

Publikováno v: Journal of chemical education [J Chem Educ] 2020 Mar 10; Vol. 97 (3), pp. 820-824. Date of Electronic Publication: 2020 Jan 21.