Výsledky vyhledávání - "Soushi Kobayashi"

Akademický článek

Flexible synthesis of poison-frog alkaloids of the 5,8-disubstituted indolizidine-class. II: Synthesis of (-)-209B, (-)-231C, (-)-233D, (-)-235B', (-)-221I, and an epimer of 193E and pharmacological effects at neuronal nicotinic acetylcholine receptors

Autor: Soushi Kobayashi, Naoki Toyooka, Dejun Zhou, Hiroshi Tsuneki, Tsutomu Wada, Toshiyasu Sasaoka, Hideki Sakai, Hideo Nemoto, H. Martin Garraffo, Thomas F. Spande, John W. Daly

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 3, Iss 1, p 30 (2007)

BackgroundThe 5,8-disubstituted indolizidines constitute the largest class of poison-frog alkaloids. Some alkaloids have been shown to act as noncompetitive blockers at nicotinic acetylcholine receptors but the proposed structures and the biological

Externí odkaz: https://doaj.org/article/90e82e3208b8463c879a1a11df9cb3c2

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Syntheses of the Proposed Structures of Poison-Frog Alkaloids 179 and 207E and Their Inhibitory Effects on Neuronal Nicotinic Acetylcholine Receptors

Autor: Hiroshi Tsuneki, null Subehan, Soushi Kobayashi, Dejun Zhou, Thomas F. Spande, Hideo Nemoto, Shigetoshi Kadota, John W. Daly, Naoki Toyooka, Hideki Sakai, H. Martin Garraffo, Toshiyasu Sasaoka, Tsutomu Wada, Yasuhiro Tezuka

Publikováno v: Synlett. 2008:61-64

Syntheses of the structures postulated for 179 and 207E, members of a proposed new class of poison-frog alkaloids, 6,7-dehydro-5,8-disubstituted indolizidines, are described. The FT-IR spectrum and GC retention time of the synthetic 207E were differe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f4c39e6b53838d6f72affa131b3e751
https://doi.org/10.1055/s-2007-1000831

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Calcineurin B homologous protein 3 negatively regulates cardiomyocyte hypertrophy via inhibition of glycogen synthase kinase 3 phosphorylation

Autor: Tomoe Y. Nakamura, Shigeo Wakabayashi, Soushi Kobayashi

Publikováno v: Journal of molecular and cellular cardiology. 84

Cardiac hypertrophy is a leading cause of serious heart diseases. Although many signaling molecules are involved in hypertrophy, the functions of some proteins in this process are still unknown. Calcineurin B homologous protein 3 (CHP3)/tescalcin is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa89a54a2528bfe490a797b51f807c32
https://pubmed.ncbi.nlm.nih.gov/25935310

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Novel Phorbol Ester-binding Motif Mediates Hormonal Activation of Na+/H+ Exchanger*

Autor: Shigeo Wakabayashi, Takashi Hisamitsu, Soushi Kobayashi, Tomoe Y. Nakamura

Protein kinase C (PKC) is considered crucial for hormonal Na(+)/H(+) exchanger (NHE1) activation because phorbol esters (PEs) strongly activate NHE1. However, here we report that rather than PKC, direct binding of PEs/diacylglycerol to the NHE1 lipid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0f213a1c34db749413c62975564659
https://europepmc.org/articles/PMC2924106/

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The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia

Autor: Masayoshi Kurachi, Toshiyasu Sasaoka, Nobuhisa Maeno, Hiroshi Tsuneki, Hikaru Seto, Masahiko Tsunoda, Tsutomu Takahashi, Yasuhiro Kawasaki, Norio Ozaki, Soushi Kobayashi, Michio Suzuki, Shi-Yu Zhou, Hirofumi Hagino, Lisha Niu

Publikováno v: Psychiatry research. 172(2)

The Disrupted-in-Schizophrenia-1 (DISC1) polymorphism is a strong candidate for a schizophrenia-susceptibility gene as it is widely expressed in cortical and limbic regions, but the effect of its genotype variation on brain morphology in schizophreni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a227161df80f03cf7fe16ee256bff90b
https://pubmed.ncbi.nlm.nih.gov/19304459

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Association between the brain-derived neurotrophic factor Val66Met polymorphism and brain morphology in a Japanese sample of schizophrenia and healthy comparisons

Autor: Masahiko Tsunoda, Norio Ozaki, Toshiyasu Sasaoka, Michio Suzuki, Shi-Yu Zhou, Soushi Kobayashi, Hiroshi Tsuneki, Tsutomu Takahashi, Hikaru Seto, Yukiko Kawamura, Masayoshi Kurachi, Yasuhiro Kawasaki, Nagahide Takahashi

Publikováno v: Neuroscience letters. 435(1)

Magnetic resonance imaging was used to investigate the relation between the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and volumetric measurements for the medial temporal lobe structures (amygdala, hippocampus, and parahippocampal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff5873824a124e30ff3bdca6923d94e
https://pubmed.ncbi.nlm.nih.gov/18325670

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