Design, synthesis, biochemical evaluation and antimycobacterial action of phosphonate inhibitors of antigen 85C, a crucial enzyme involved in biosynthesis of the mycobacterial cell wall

Autor: Urban Švajger, Rosalind A. Wilson, Danijel Kikelj, Stanislav Gobec, Sousana L. Soares, Gurdyal S. Besra, Rui Appelberg, Janez Mravljak, Ivan Plantan

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Phosphonate inhibitors of antigen 85C were prepared. The inhibitors, comprising a phosphonate moiety, mycolic acid mimetic and a trehalose surrogate, contain substituted benzyl alcohols, N-(omega-hydroxyalky)phthalimide, 2-phenylethanol or 4-(phthali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a94d6001c6ce67e73f3105306ee077a
https://doi.org/10.1016/j.ejmech.2006.08.007