Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Soumya S. Ray"'
Autor:
Malek Najjar, Chalada Suebsuwong, Soumya S. Ray, Roshan J. Thapa, Jenny L. Maki, Shoko Nogusa, Saumil Shah, Danish Saleh, Peter J. Gough, John Bertin, Junying Yuan, Siddharth Balachandran, Gregory D. Cuny, Alexei Degterev
Publikováno v:
Cell Reports, Vol 10, Iss 11, Pp 1850-1860 (2015)
RIPK1 and RIPK3, two closely related RIPK family members, have emerged as important regulators of pathologic cell death and inflammation. In the current work, we report that the Bcr-Abl inhibitor and anti-leukemia agent ponatinib is also a first-in-c
Externí odkaz:
https://doaj.org/article/8f65f93adb5c4e25b86a268a30510c2f
Publikováno v:
Journal of Chemical Information and Modeling. 63:1668-1674
Machine learning protein structure prediction, such as RosettaFold and AlphaFold2, have impacted the structural biology field, raising a fair amount of discussion around its potential role in drug discovery. While we find some preliminary studies add
Publikováno v:
Journal of Chemical Information and Modeling. 62:4351-4360
The availability of AlphaFold2 has led to great excitement in the scientific community─particularly among drug hunters─due to the ability of the algorithm to predict protein structures with high accuracy. However, beyond globally accurate protein
Autor:
Ryan J. Lumpkin, Julia M. Rogers, Eric S. Fischer, Katherine A. Donovan, Ruili Cao, Vidyasiri Vemulapalli, Gregory D. Cuny, Soumya S. Ray, Stephen C. Blacklow, Matthew T. Henke, Munhyung Bae, Tom C. M. Seegar
Publikováno v:
Biochemistry
SHP2 is a protein tyrosine phosphatase that plays a critical role in the full activation of the Ras/MAPK pathway upon stimulation of receptor tyrosine kinases (RTKs), which are frequently amplified or mutationally activated in human cancer. In additi
Autor:
Andrea Armirotti, Ilaria Penna, Natasha Margaroli, Rosalia Bertorelli, Piero Tardia, Giuliana Ottonello, Marco Mazzonna, Sine Mandrup Bertozzi, Cilibrasi Vincenzo, Maria Summa, Simona Di Martino, Samantha Caputo, Debora Russo, Marco Migliore, Rita Scarpelli, Renato T. Skerlj, Natalia Realini, Soumya S. Ray, Min Liu, Peter T. Lansbury
Publikováno v:
Journal of Medicinal Chemistry
Acid ceramidase (AC) is a cysteine hydrolase that plays a crucial role in the metabolism of lysosomal ceramides, important members of the sphingolipid family, a diversified class of bioactive molecules that mediate many biological processes ranging f
Autor:
William Sinko, Petr Kocis, Howard Fillit, Soumya S. Ray, John Hey, Kaj Blennow, Jeremy Yu, Martin Tolar
Publikováno v:
CNS Drugs
Background Amyloid beta (Aβ) oligomers play a critical role in the pathogenesis of Alzheimer’s disease (AD) and represent a promising target for drug development. Tramiprosate is a small-molecule Aβ anti-aggregation agent that was evaluated in ph
Autor:
Christopher Negron, Soumya S. Ray, John D. Chodera, Kevin Hauser, Robert Abel, Lingle Wang, Steven K. Albanese, Thomas Steinbrecher
Publikováno v:
Communications Biology, Vol 1, Iss 1, Pp 1-14 (2018)
The therapeutic effect of targeted kinase inhibitors can be significantly reduced by intrinsic or acquired resistance mutations that modulate the affinity of the drug for the kinase. In cancer, the majority of missense mutations are rare, making it d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f45ebfb6d0c45605e7ffcc04b146321
https://doi.org/10.1101/239012
https://doi.org/10.1101/239012
Autor:
Saumil Shah, Shoko Nogusa, John Bertin, Gregory D. Cuny, Jenny L. Maki, Chalada Suebsuwong, Junying Yuan, Peter J. Gough, Malek Najjar, Soumya S. Ray, Roshan J. Thapa, Danish Saleh, Siddharth Balachandran, Alexei Degterev
Publikováno v:
Cell Reports, Vol 10, Iss 11, Pp 1850-1860 (2015)
SummaryRIPK1 and RIPK3, two closely related RIPK family members, have emerged as important regulators of pathologic cell death and inflammation. In the current work, we report that the Bcr-Abl inhibitor and anti-leukemia agent ponatinib is also a fir
Publikováno v:
Expert opinion on therapeutic patents. 27(6)
Inosine-5'-monophosphate dehydrogenase (IMPDH) is an enzyme involved in the de novo biosynthesis of guanine nucleotides. To date human IMPDH inhibitors have been approved for prevention of organ transplant rejection and as anti-viral agents. More rec
Autor:
Dariusz Pytel, Kathleen Seyb, Min Liu, Gregory D. Cuny, John Concannon, J. Alan Diehl, Soumya S. Ray, Mickey Huang, Marcie A. Glicksman
Publikováno v:
SLAS Discovery. 19:1024-1034
PERK is serine/threonine kinase localized to the endoplasmic reticulum (ER) membrane. PERK is activated and contributes to cell survival in response to a variety of physiological stresses that affect protein quality control in the ER, such as hypoxia