OphthatomeTM: An integrated knowledgebase of ophthalmic diseases for translating vision research into the clinic

Autor: Praveen Raj, Sushma Tejwani, Dandayudhapani Sudha, Muthu Narayanan B, Chandrasekar Thangapandi, Sankar Das, Somasekar J, Susmithasane Mangalapudi, Durgesh Kumar, Narendra Pindipappanahalli, Rohit Shetty, Arkashubra Ghosh, Govindasamy Kumaramanickavel, Amitabha Chaudhuri, Soumittra Nagaswamy

Abstract Background: Medical big data analytics has revolutionized the human healthcare system by introducing processes that facilitate rationale clinical decision making, predictive or prognostic modelling of the disease progression and management,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9761dcf37693a97505531e1e9b2e1b99
https://doi.org/10.21203/rs.3.rs-35644/v3

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Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma.

Autor: Khor CC; Genome Institute of Singapore, A-STAR, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.; Department of Biochemistry, National University of Singapore, Singapore., Do T; Vietnam National Institute of Ophthalmology, Hanoi, Vietnam., Jia H; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China., Nakano M; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan., George R; Jadhavbhai Nathamal Singhvi Department of Glaucoma, Medical Research Foundation, Sankara Nethralaya, Chennai, India., Abu-Amero K; Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.; Department of Ophthalmology, College of Medicine, University of Florida, Jacksonville, Florida, USA., Duvesh R; Department of Genetics, Aravind Medical Research Foundation, Madurai, India., Chen LJ; Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China., Li Z; Genome Institute of Singapore, A-STAR, Singapore., Nongpiur ME; Singapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore., Perera SA; Singapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore., Qiao C; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China., Wong HT; Department of Ophthalmology, Tan Tock Seng Hospital, NHG Eye Institute, Singapore., Sakai H; Department of Ophthalmology, University of the Ryukyus, Okinawa, Nishihara, Japan., Barbosa de Melo M; Center of Molecular Biology and Genetic Engineering, University of Campinas, Campinas, Brazil., Lee MC; Singapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore., Chan AS; Singapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore., Azhany Y; Department of Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia and Hospital Universiti Sains Malaysia, Kelantan, Malaysia., Dao TL; Vietnam National Institute of Ophthalmology, Hanoi, Vietnam., Ikeda Y; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Perez-Grossmann RA; Instituto de Glaucoma y Catarata, Lima, Peru., Zarnowski T; Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland., Day AC; NIHR Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital and University College London Institute of Ophthalmology, London, UK.; Glaucoma Service, Moorfields Eye Hospital NHS Foundation Trust, London, UK.; Division of Genetics, UCL Institute of Ophthalmology, London, UK., Jonas JB; Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht Karls University Heidelberg, Heidelberg, Germany., Tam PO; Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China., Tran TA; Ho Chi Minh City Eye Hospital, Ho Chi Minh City, Vietnam., Ayub H; Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan., Akhtar F; Pakistan Institute of Ophthalmology, Al-Shifa Trust Eye Hospital, Rawalpindi, Pakistan., Micheal S; Department of Ophthalmology, Radboud University Medical Centre, Nijmegen, the Netherlands., Chew PT; Department of Ophthalmology, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Aljasim LA; King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia., Dada T; All India Institute of Medical Sciences, New Delhi, India., Luu TT; Department of Glaucoma, Da Nang Eye Hospital, Da Nang City, Vietnam., Awadalla MS; Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia., Kitnarong N; Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Wanichwecharungruang B; Glaucoma Services, Department of Ophthalmology, Rajavithi Hospital, Bangkok, Thailand.; College of Medicine, Rangsit University, Bangkok, Thailand., Aung YY; Mandalay Eye Department, Mandalay Eye ENT Hospital, University of Medicine Mandalay, Mandalay, Myanmar., Mohamed-Noor J; Department of Ophthalmology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia., Vijayan S; Department of Genetics, Aravind Medical Research Foundation, Madurai, India., Sarangapani S; Vision Research Foundation, Sankara Nethralaya, Chennai, India., Husain R; Singapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.; Division of Ophthalmology, Changi General Hospital, Singapore., Jap A; Singapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.; Division of Ophthalmology, Changi General Hospital, Singapore., Baskaran M; Singapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore., Goh D; Singapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore., Su DH; Singapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore., Wang H; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China., Yong VK; Department of Ophthalmology, Tan Tock Seng Hospital, NHG Eye Institute, Singapore., Yip LW; Department of Ophthalmology, Tan Tock Seng Hospital, NHG Eye Institute, Singapore., Trinh TB; Ho Chi Minh City Eye Hospital, Ho Chi Minh City, Vietnam., Makornwattana M; Department of Ophthalmology, Thammasat University Faculty of Medicine, Rangsit, Thailand., Nguyen TT; Eye Department, Viet Tiep General Hospital, Hai Phong, Vietnam., Leuenberger EU; Asian Eye Institute, Manila, Philippines.; Division of Ophthalmology, University of the East, Manila, Philippines., Park KH; Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Republic of Korea., Wiyogo WA; Glaucoma Service Jakarta Eye Center, Jakarta, Indonesia.; Faculty of Medicine, University of Indonesia, Jakarta, Indonesia., Kumar RS; Narayana Nethralaya Eye Hospital, Bangalore, India., Tello C; Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, USA., Kurimoto Y; Department of Ophthalmology, Kobe City Medical Center General Hospital, Kobe, Japan., Thapa SS; Nepal Glaucoma Eye Clinic, Tilganga Institute of Ophthalmology, Kathmandu, Nepal., Pathanapitoon K; Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand., Salmon JF; Oxford Eye Hospital, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford, UK., Sohn YH; Department of Ophthalmology, Konyang University, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Seoul, Republic of Korea., Fea A; Dipartimento di Scienze Chirurgiche, Università di Torino, Turin, Italy., Ozaki M; Ozaki Eye Hospital, Hyuga, Japan.; Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan., Lai JS; Department of Ophthalmology, University of Hong Kong, Hong Kong, China., Tantisevi V; Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Khaing CC; Department of Ophthalmology, No. 1 Defence Services General Hospital, Yangon, Myanmar., Mizoguchi T; Mizoguchi Eye Hospital, Sasebo, Japan., Nakano S; Department of Ophthalmology, Oita University Faculty of Medicine, Oita, Japan., Kim CY; Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Republic of Korea., Tang G; Shijiazhuang First Eye Hospital, Shijiazhuang, China., Fan S; Handan Eye Hospital, Handan, China., Wu R; Eye Institute and Affiliated Xiamen Eye Center, Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, China., Meng H; Anyang Eye Hospital, Anyang, China., Nguyen TT; Vietnam National Institute of Ophthalmology, Hanoi, Vietnam., Tran TD; Vietnam National Institute of Ophthalmology, Hanoi, Vietnam., Ueno M; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Martinez JM; Department of Ophthalmology, Pasig City General Hospital, Pasig City, Philippines., Ramli N; University of Malaya, Eye Research Centre, Kuala Lumpur, Malaysia.; Department of Ophthalmology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Aung YM; Myanmar Eye Centre, Pun Hlaing Silom Hospital, Yangon, Myanmar.; Myanmar Eye Centre, Shwe La Min Hospital, Yangon, Myanmar., Reyes RD; Department of Ophthalmology/Glaucoma Section, Asian Hospital and Medical Center, Muntinlupa City, Philippines.; Binan Doctors Eye Center, Binan Doctors Hospital, Laguna, Philippines., Vernon SA; Department of Ophthalmology, University Hospital Nottingham, University of Nottingham, Nottingham, UK.; BMI Park Hospital Nottingham, Nottingham, UK., Fang SK; International Specialist Eye Centre, Kuala Lumpur, Malaysia., Xie Z; Genome Institute of Singapore, A-STAR, Singapore., Chen XY; Genome Institute of Singapore, A-STAR, Singapore., Foo JN; Genome Institute of Singapore, A-STAR, Singapore., Sim KS; Genome Institute of Singapore, A-STAR, Singapore., Wong TT; Singapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore., Quek DT; Singapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore., Venkatesh R; Glaucoma Clinic, Aravind Eye Hospital, Pondicherry, India., Kavitha S; Glaucoma Clinic, Aravind Eye Hospital, Pondicherry, India., Krishnadas SR; Glaucoma Clinic, Aravind Eye Hospital, Madurai, India., Soumittra N; Vision Research Foundation, Sankara Nethralaya, Chennai, India., Shantha B; Jadhavbhai Nathamal Singhvi Department of Glaucoma, Medical Research Foundation, Sankara Nethralaya, Chennai, India., Lim BA; Department of Ophthalmology, Tan Tock Seng Hospital, NHG Eye Institute, Singapore., Ogle J; Department of Ophthalmology, Tan Tock Seng Hospital, NHG Eye Institute, Singapore., de Vasconcellos JP; Department of Ophthalmology, Faculty of Medical Sciences, University of Campinas, Campinas, Brazil., Costa VP; Glaucoma Clinic, Aravind Eye Hospital, Madurai, India., Abe RY; Glaucoma Clinic, Aravind Eye Hospital, Madurai, India., de Souza BB; Center of Molecular Biology and Genetic Engineering, University of Campinas, Campinas, Brazil., Sng CC; Department of Ophthalmology, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Aquino MC; Department of Ophthalmology, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Kosior-Jarecka E; Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland., Fong GB; Instituto de Ciencias Médicas, Lima, Peru., Tamanaja VC; Hospital Nacional Arzobispo Loayza, Lima, Peru., Fujita R; Centro de Genética y Biología Molecular, Universidad de San Martín de Porres, Lima, Peru., Jiang Y; NIHR Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital and University College London Institute of Ophthalmology, London, UK.; Glaucoma Service, Moorfields Eye Hospital NHS Foundation Trust, London, UK.; Division of Genetics, UCL Institute of Ophthalmology, London, UK., Waseem N; NIHR Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital and University College London Institute of Ophthalmology, London, UK.; Division of Genetics, UCL Institute of Ophthalmology, London, UK., Low S; NIHR Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital and University College London Institute of Ophthalmology, London, UK.; Glaucoma Service, Moorfields Eye Hospital NHS Foundation Trust, London, UK.; Division of Genetics, UCL Institute of Ophthalmology, London, UK., Pham HN; Ho Chi Minh City Eye Hospital, Ho Chi Minh City, Vietnam., Al-Shahwan S; King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia., Craven ER; King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.; Wilmer Eye Institute, Johns Hopkins Hospital School of Medicine, Baltimore, Maryland, USA., Khan MI; Department of Human Genetics, Radboud University Medical Centre, Nijmegen, the Netherlands., Dada R; All India Institute of Medical Sciences, New Delhi, India., Mohanty K; All India Institute of Medical Sciences, New Delhi, India., Faiq MA; All India Institute of Medical Sciences, New Delhi, India., Hewitt AW; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.; Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia., Burdon KP; Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia.; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia., Gan EH; Department of Ophthalmology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia., Prutthipongsit A; Department of Ophthalmology, Thammasat University Faculty of Medicine, Rangsit, Thailand., Patthanathamrongkasem T; Department of Ophthalmology, Thammasat University Faculty of Medicine, Rangsit, Thailand., Catacutan MA; Asian Eye Institute, Manila, Philippines., Felarca IR; Asian Eye Institute, Manila, Philippines., Liao CS; Asian Eye Institute, Manila, Philippines., Rusmayani E; Glaucoma Service Jakarta Eye Center, Jakarta, Indonesia., Istiantoro VW; Glaucoma Service Jakarta Eye Center, Jakarta, Indonesia., Consolandi G; Dipartimento di Scienze Chirurgiche, Università di Torino, Turin, Italy., Pignata G; Dipartimento di Scienze Chirurgiche, Università di Torino, Turin, Italy., Lavia C; Dipartimento di Scienze Chirurgiche, Università di Torino, Turin, Italy., Rojanapongpun P; Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Mangkornkanokpong L; Department of Ophthalmology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand., Chansangpetch S; Department of Ophthalmology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand., Chan JC; Department of Ophthalmology, Queen Mary Hospital, Hong Kong, China., Choy BN; Department of Ophthalmology, University of Hong Kong, Hong Kong, China., Shum JW; Department of Ophthalmology, University of Hong Kong, Hong Kong, China., Than HM; Department of Ophthalmology, North Okkalarpa General Hospital, Yangon, Myanmar., Oo KT; Myanmar Eye Centre, Pun Hlaing Silom Hospital, Yangon, Myanmar.; Myanmar Eye Centre, Shwe La Min Hospital, Yangon, Myanmar., Han AT; Myanmar Eye Centre, Pun Hlaing Silom Hospital, Yangon, Myanmar.; Myanmar Eye Centre, Shwe La Min Hospital, Yangon, Myanmar., Yong VH; Singapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore., Ng XY; Singapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore., Goh SR; Singapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore., Chong YF; Singapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore., Hibberd ML; Genome Institute of Singapore, A-STAR, Singapore., Seielstad M; Institute for Human Genetics, University of California, San Francisco, San Francisco, California, USA., Png E; Genome Institute of Singapore, A-STAR, Singapore., Dunstan SJ; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia., Chau NV; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Bei J; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.; Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, China., Zeng YX; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.; Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, China.; Peking Union Medical College, Beijing, China., Karkey A; Oxford University Clinical Research Unit-Nepal, Patan Academy of Health Sciences, Patan Hospital, Patan, Nepal., Basnyat B; 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Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, USA., Hauser MA; Singapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.; Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, USA.; Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA., Lim ST; Division of Medical Oncology, National Cancer Centre, Singapore., Chew SH; Department of Economics, National University of Singapore, Singapore., Ebstein RP; Department of Psychology, National University of Singapore, Singapore., Sakuntabhai A; Institut Pasteur, Functional Genetics of Infectious Diseases Unit, Department of Genomes and Genetics, Paris, France.; Centre National de la Recherche Scientifique, Unité de Recherche Associée 3012, Paris, France., Park KH; Department of Ophthalmology, Seoul National University Bundang Hospital, Gyeonggi, Republic of Korea., Ahn J; Department of Ophthalmology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Republic of Korea., Boland G; Department of Medical Microbiology and Virology, University Medical Center Utrecht, Utrecht, the Netherlands., Snippe H; Department of Medical Microbiology and Virology, University Medical Center Utrecht, Utrecht, the Netherlands., Stead R; Department of Ophthalmology, University Hospital Nottingham, University of Nottingham, Nottingham, UK., Quino R; Department of Ophthalmology/Glaucoma Section, Asian Hospital and Medical Center, Muntinlupa City, Philippines., Zaw SN; Myanmar Eye Centre, Pun Hlaing Silom Hospital, Yangon, Myanmar.; Myanmar Eye Centre, Shwe La Min Hospital, Yangon, Myanmar., Lukasik U; Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland., Shetty R; Narayana Nethralaya Eye Hospital, Bangalore, India., Zahari M; University of Malaya, Eye Research Centre, Kuala Lumpur, Malaysia.; Department of Ophthalmology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Bae HW; Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Republic of Korea., Oo NL; Department of Ophthalmology, No. 1 Defence Services General Hospital, Yangon, Myanmar., Kubota T; Department of Ophthalmology, Oita University Faculty of Medicine, Oita, Japan., Manassakorn A; Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Ho WL; Department of Ophthalmology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand., Dallorto L; Dipartimento di Scienze Chirurgiche, Università di Torino, Turin, Italy., Hwang YH; Department of Ophthalmology, Konyang University, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Seoul, Republic of Korea., Kiire CA; Oxford Eye Hospital, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford, UK., Kuroda M; Department of Ophthalmology, Kobe City Medical Center General Hospital, Kobe, Japan., Djamal ZE; Glaucoma Service Jakarta Eye Center, Jakarta, Indonesia., Peregrino JI; Asian Eye Institute, Manila, Philippines., Ghosh A; Narayana Nethralaya Eye Hospital, Bangalore, India.; GROW Research Laboratory, Narayana Nethralaya Foundation, Bangalore, India., Jeoung JW; Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Republic of Korea., Hoan TS; Eye Department, Viet Tiep General Hospital, Hai Phong, Vietnam., Srisamran N; Department of Ophthalmology, Thammasat University Faculty of Medicine, Rangsit, Thailand., Sandragasu T; Department of Ophthalmology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia., Set SH; Mandalay Eye Department, Mandalay Eye ENT Hospital, University of Medicine Mandalay, Mandalay, Myanmar., Doan VH; Department of Glaucoma, Da Nang Eye Hospital, Da Nang City, Vietnam., Bhattacharya SS; Division of Genetics, UCL Institute of Ophthalmology, London, UK., Ho CL; Singapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore., Tan DT; Singapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore., Sihota R; All India Institute of Medical Sciences, New Delhi, India., Loon SC; Department of Ophthalmology, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Mori K; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Kinoshita S; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Hollander AI; Department of Ophthalmology, Radboud University Medical Centre, Nijmegen, the Netherlands.; Department of Human Genetics, Radboud University Medical Centre, Nijmegen, the Netherlands., Qamar R; Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan.; Department of Biochemistry, Al-Nafees Medical College and Hospital, Isra University, Islamabad, Pakistan., Wang YX; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Teo YY; Genome Institute of Singapore, A-STAR, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.; Life Sciences Institute, National University of Singapore, Singapore.; National University of Singapore Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore.; Department of Statistics and Applied Probability, National University of Singapore, Singapore., Tai ES; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Hartleben-Matkin C; Department of Glaucoma, Institute of Ophthalmology 'Conde de Valenciana', Mexico City, Mexico., Lozano-Giral D; Department of Genetics, Institute of Ophthalmology 'Conde de Valenciana', Mexico City, Mexico., Saw SM; Singapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.; Department of Ophthalmology, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Zenteno JC; Department of Genetics, Institute of Ophthalmology 'Conde de Valenciana', Mexico City, Mexico.; Department of Biochemistry, Faculty of Medicine, Universidad Nacional Autónoma de México, Mexico City, Mexico., Pang CP; Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China., Bui HT; Ho Chi Minh City Eye Hospital, Ho Chi Minh City, Vietnam., Hee O; Department of Ophthalmology, Tan Tock Seng Hospital, NHG Eye Institute, Singapore., Craig JE; Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia., Edward DP; King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.; Wilmer Eye Institute, Johns Hopkins Hospital School of Medicine, Baltimore, Maryland, USA., Yonahara M; Department of Ophthalmology, University of the Ryukyus, Okinawa, Nishihara, Japan., Neto JM; Department of Ophthalmology, Faculty of Medical Sciences, University of Campinas, Campinas, Brazil., Guevara-Fujita ML; Centro de Genética y Biología Molecular, Universidad de San Martín de Porres, Lima, Peru., Xu L; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Ritch R; Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, USA., Liza-Sharmini AT; Department of Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia and Hospital Universiti Sains Malaysia, Kelantan, Malaysia., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore., Al-Obeidan S; Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Do NH; Vietnam National Institute of Ophthalmology, Hanoi, Vietnam., Sundaresan P; Department of Genetics, Aravind Medical Research Foundation, Madurai, India., Tham CC; Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China., Foster PJ; NIHR Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital and University College London Institute of Ophthalmology, London, UK.; Glaucoma Service, Moorfields Eye Hospital NHS Foundation Trust, London, UK.; Division of Genetics, UCL Institute of Ophthalmology, London, UK., Vijaya L; Singapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.; Jadhavbhai Nathamal Singhvi Department of Glaucoma, Medical Research Foundation, Sankara Nethralaya, Chennai, India., Tashiro K; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan., Vithana EN; Singapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore., Wang N; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China.; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Aung T; Singapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.; Department of Ophthalmology, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Publikováno v: Nature genetics [Nat Genet] 2016 May; Vol. 48 (5), pp. 556-62. Date of Electronic Publication: 2016 Apr 04.