Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Soumendranath Bhakat"'
Publikováno v:
PLoS ONE, Vol 19, Iss 8 (2024)
Externí odkaz:
https://doaj.org/article/22df0227cb6948d7a1b0099fed2ca587
Publikováno v:
Molecules, Vol 20, Iss 2, Pp 1984-2000 (2015)
he present art of drug discovery and design of new drugs is based on suicidal irreversible inhibitors. Covalent inhibition is the strategy that is used to achieve irreversible inhibition. Irreversible inhibitors interact with their targets in a time-
Externí odkaz:
https://doaj.org/article/5bc4d57ebf974477a431de2784053601
Autor:
Somnath Bhakat, Soumendranath Bhakat
Publikováno v:
Journal of Entomology and Zoology Studies. 11:111-117
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c139e797ccc69936547d8865234863cb
https://doi.org/10.22271/j.ento.2023.v11.i1b.9132
https://doi.org/10.22271/j.ento.2023.v11.i1b.9132
Autor:
Pär Söderhjelm, Soumendranath Bhakat
Publikováno v:
Journal of Chemical Information and Modeling. 62:914-926
The flexibility of aβhairpin structure known as theflapplays a key role in catalytic activity and substrate intake in pepsin-like aspartic proteases. Most of these enzymes share structural and sequential similarity. In the apo form of the proteases,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d80d0f64133a58eeb53393521235f5
https://doi.org/10.1021/acs.jcim.1c00840
https://doi.org/10.1021/acs.jcim.1c00840
Autor:
Soumendranath Bhakat
Publikováno v:
RSC Advances. 12:25010-25024
Understanding kinetics and thermodynamics profile of biomolecules is necessary to understand their functional roles which has a major impact in mechanism driven drug discovery. Molecular dynamics simulation has been routinely used to understand confo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c397f9bda32e49849733978955d1347c
https://doi.org/10.1039/d2ra03660f
https://doi.org/10.1039/d2ra03660f
Cryptic pockets, or pockets absent in ligand-free, experimentally determined structures, hold great potential as drug targets. However, cryptic pocket opening is often beyond the reach of conventional biomolecular simulations because certain cryptic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b047a6921b61f714415ba430bcd7262
https://doi.org/10.1101/2022.11.23.517577
https://doi.org/10.1101/2022.11.23.517577
Autor:
Soumendranath Bhakat
Publikováno v:
RSC Advances. 11:11026-11047
Pepsin-like aspartic proteases (PAPs) are a class of aspartic proteases which shares tremendous structural similarity with human pepsin. One of the key structural features of PAPs is the presence of a β-hairpin motif otherwise known as flap. The bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::240fe8975e695c0a573a5f0378ef115f
https://doi.org/10.1039/d0ra10359d
https://doi.org/10.1039/d0ra10359d
Autor:
Soumendranath Bhakat, Pär Söderhjelm
Hydrogen exchange (HX) between protein amides and solvent water molecules can function as a probe for protein dynamics and provide a bridge between the experimental and computational worlds. However, it is important that the underlying assumptions ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3aebf4999055cbbe62ac0d1098d4c846
https://doi.org/10.1101/2022.05.19.492675
https://doi.org/10.1101/2022.05.19.492675
A nepenthesin insert allosterically controls catalysis in the malaria parasite protease plasmepsin V
Autor:
Alexander J. Polino, Justin J. Miller, Soumendranath Bhakat, Suhas Bobba, Gregory R. Bowman, Daniel E. Goldberg
Plasmepsin V (PM V) is a pepsin-like aspartic protease essential for growth of the malaria parasite Plasmodium falciparum. Previous work has shown PM V to be an ER-resident protease that processes parasite proteins destined for export into the host c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2feeccc0df2fd036695659c27419238
https://doi.org/10.1101/2022.02.28.482356
https://doi.org/10.1101/2022.02.28.482356
Autor:
Soumendranath Bhakat, Somnath Bhakat
A new species of the genusMicrohyla,Microhyla bengalensissp. nov., described from West Bengal state, India. The new species is distinguished from its congeners by a combination of the following morphological characters: 1) Small in size (SVL= 16.2 mm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1daa8cf1fca10e1be42caa8a8d51db0c
https://doi.org/10.1101/2021.08.07.455509
https://doi.org/10.1101/2021.08.07.455509