Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Soumajit Dutta"'
Autor:
Soumajit Dutta, Diwakar Shukla
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-16 (2023)
Abstract Design of cannabinergic subtype selective ligands is challenging because of high sequence and structural similarities of cannabinoid receptors (CB1 and CB2). We hypothesize that the subtype selectivity of designed selective ligands can be ex
Externí odkaz:
https://doaj.org/article/ac7856af4e014b7e90a27c429cfef455
Autor:
Gabriel V. Pereira, Ahmed M. Abdel-Hamid, Soumajit Dutta, Corina N. D’Alessandro-Gabazza, Daniel Wefers, Jacob A. Farris, Shiv Bajaj, Zdzislaw Wawrzak, Haruyuki Atomi, Roderick I. Mackie, Esteban C. Gabazza, Diwakar Shukla, Nicole M. Koropatkin, Isaac Cann
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Human gut bacteria can degrade arabinoxylans, polysaccharides found in dietary fiber. Here, Pereira et al. identify a bacterial gene cluster encoding esterases for degradation of complex arabinoxylans. The action of these enzymes results in accumulat
Externí odkaz:
https://doaj.org/article/a693c91c120a47879d9d18e9d9404ea3
Publikováno v:
Biophysical Journal. 122:1400-1413
Smoothened (SMO) is a membrane protein of the Class F subfamily of G-Protein Coupled Receptors (GPCRs) and maintains homeostasis of cellular differentiation. SMO undergoes conformational change during activation, transmitting the signal across the me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be02cd7170aa528f5b2d67540d1afbaa
https://doi.org/10.1016/j.bpj.2023.03.007
https://doi.org/10.1016/j.bpj.2023.03.007
Autor:
Lianghui Zhang, Soumajit Dutta, Shiqin Xiong, Matthew Chan, Kui K. Chan, Timothy M. Fan, Keith L. Bailey, Matthew Lindeblad, Laura M. Cooper, Lijun Rong, Anthony F. Gugliuzza, Diwakar Shukla, Erik Procko, Jalees Rehman, Asrar B. Malik
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Vaccine hesitancy and continuing emergence of SARS-CoV-2 variants of concern that may escape vaccine-induced immune responses highlight the urgent need for effective COVID-19 therapeutics. Monoclonal antibodies used in the clinic have varying efficac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92421ad0a61cf2a60c20be6b986a48b3
https://pubmed.ncbi.nlm.nih.gov/35046611
https://pubmed.ncbi.nlm.nih.gov/35046611
Autor:
Lianghui Zhang, Soumajit Dutta, Shiqin Xiong, Matthew Chan, Kui K. Chan, Timothy M. Fan, Keith L. Bailey, Matthew Lindeblad, Laura M. Cooper, Lijun Rong, Anthony F. Gugliuzza, Diwakar Shukla, Erik Procko, Jalees Rehman, Asrar B. Malik
Publikováno v:
Nature chemical biology. 18(3)
Vaccine hesitancy and emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) escaping vaccine-induced immune responses highlight the urgency for new COVID-19 therapeutics. Engineered angiotensin-convertin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1abd00c7e9d4cc7fec0bb9a48203e667
https://pubmed.ncbi.nlm.nih.gov/35282893
https://pubmed.ncbi.nlm.nih.gov/35282893
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
A robust synthesis methodology for crystallizing nanoporous single-layer graphene hosting a high density of size-selective nanopores is urgently needed to realize the true potential of two-dimensional membranes for gas separation. Currently, there ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5448f5527f26fb47f251c3bee90c7f9e
http://link.springer.com/article/10.1038/s41598-019-41645-9
http://link.springer.com/article/10.1038/s41598-019-41645-9
Cannabinoid receptor 1 (CB1) is a therapeutically relevant drug target for controlling pain, obesity, and other central nervous system disorders. However, full agonists and antagonists of CB1have been reported to cause serious side effects in patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28d6c86198fc8fa51d716ef1f01bfc96
https://doi.org/10.1101/2021.04.29.441987
https://doi.org/10.1101/2021.04.29.441987
The therapeutical potential of Cannabinoid receptors is not fully explored due to psychoactive side-effects and lack of selectivity associated with the orthosteric ligands. Allosteric modulators have the potential to become selective therapeutics for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b508840371914854a8ee567fdfb420df
https://doi.org/10.1101/2021.04.07.438766
https://doi.org/10.1101/2021.04.07.438766
Publikováno v:
Journal of Biological Chemistry. 298:101764
Cannabinoid receptor 1 (CB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db6378f56eca0ba79f964083657ad7b
https://doi.org/10.1016/j.jbc.2022.101764
https://doi.org/10.1016/j.jbc.2022.101764
Autor:
David W. Murhammer, Ashok Kumar Das, Jitendra Kumar, Jayanta Chakraborty, Abha Saxena, Lopamudra Giri, Moumita Sen, Soumajit Dutta
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 118(1)
Baculoviruses have enormous potential for use as biopesticides to control insect pest populations without the adverse environmental effects posed by the widespread use of chemical pesticides. However, continuous baculovirus production is susceptible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::766f590cb8a855d231038ce1bd5ff4a6
https://pubmed.ncbi.nlm.nih.gov/32936454
https://pubmed.ncbi.nlm.nih.gov/32936454