Macrophage-derived LTB4 promotes abscess formation and clearance of Staphylococcus aureus skin infection in mice.

Autor: Stephanie L Brandt, Nathan Klopfenstein, Soujuan Wang, Seth Winfree, Brian P McCarthy, Paul R Territo, Lloyd Miller, C Henrique Serezani

Publikováno v: PLoS Pathogens, Vol 14, Iss 8, p e1007244 (2018)

The early events that shape the innate immune response to restrain pathogens during skin infections remain elusive. Methicillin-resistant Staphylococcus aureus (MRSA) infection engages phagocyte chemotaxis, abscess formation, and microbial clearance.

Externí odkaz: https://doaj.org/article/b671edee100040cb8d56d453493af4b1

MicroRNA 21 is a homeostatic regulator of macrophage polarization and prevents prostaglandin E2-mediated M2 generation.

Autor: Zhuo Wang, Stephanie Brandt, Alexandra Medeiros, Soujuan Wang, Hao Wu, Alexander Dent, C Henrique Serezani

Publikováno v: PLoS ONE, Vol 10, Iss 2, p e0115855 (2015)

Macrophages dictate both initiation and resolution of inflammation. During acute inflammation classically activated macrophages (M1) predominate, and during the resolution phase alternative macrophages (M2) are dominant. The molecular mechanisms invo

Externí odkaz: https://doaj.org/article/d99ffa299ee04f419fd1d640f5ead9f7

Nuclear PTEN enhances the maturation of a microRNA regulon to limit MyD88-dependent susceptibility to sepsis

Autor: Sonia Jancar, Charles S. Dela Cruz, Flavia Sisti, Soujuan Wang, Sarah M. Sturgeon, C. Henrique Serezani, Hector R. Wong, Young Min Son, Nathaniel Andrews, José C. Alves-Filho, Lindsey D. Mayo, Fernando Q. Cunha, Stephanie L. Brandt, Nicole L. Glosson-Byers, Luciano Filgueiras

Publikováno v: Sci Signal

Sepsis-induced organ damage is caused by systemic inflammatory response syndrome (SIRS), which results in substantial comorbidities. Therefore, it is of medical importance to identify molecular brakes that can be exploited to dampen inflammation and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c4432aff6d95d709e0e9bed17c8d56
https://doi.org/10.1126/scisignal.aai9085

SOCS1 is a negative regulator of metabolic reprogramming during sepsis

Autor: Hector R. Wong, Sarah M. Sturgeon, Annie Rocio Piñeros Alvarez, Soujuan Wang, C. Henrique Serezani, Paul R. Territo, Stephanie L. Brandt, José C. Alves-Filho, Brian P. McCarthy, Nicole L. Glosson-Byers

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Sepsis can induce an overwhelming systemic inflammatory response, resulting in organ damage and death. Suppressor of cytokine signaling 1 (SOCS1) negatively regulates signaling by cytokine receptors and Toll-like receptors (TLRs). However, the cellul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a35f0e96e3bcb8ddf8e7444902da7f1

MicroRNA 21 is a homeostatic regulator of macrophage polarization and prevents prostaglandin E2-mediated M2 generation

Autor: Soujuan Wang, Stephanie L. Brandt, Hao Wu, Alexander L. Dent, C. Henrique Serezani, Zhuo Wang, Alexandra Ivo de Medeiros

Publikováno v: PLoS ONE
Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
PLoS ONE, Vol 10, Iss 2, p e0115855 (2015)

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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9728c2417dc306c55e07500838ff7f09
https://pubmed.ncbi.nlm.nih.gov/25706647