The combination of Bleomycin with TRAIL agonists or PKC inhibitors sensitizes solid tumor cells to BLM-mediated apoptosis: new strategies to overcome chemotherapy resistance of tumors

Autor: Sonia Aroui, Ali Bettaieb, Abderraouf Kenani, Souhir Brahim, Jean F. Jeannin, Rahamata Ali

Publikováno v: Medicinal Chemistry Research
Medicinal Chemistry Research, Springer Verlag, 2017, pp.1-7. 〈https://link.springer.com/article/10.1007/s00044-017-1915-9〉. 〈10.1007/s00044-017-1915-9〉
Medicinal Chemistry Research, Springer Verlag, 2017, pp.1-7. ⟨10.1007/s00044-017-1915-9⟩

IF 1.436; International audience; In this study we evaluated the effects of low dose of bleomycin in an associative treatment strategy in solid tumor cells. For this purpose, Human and murine colon cancer (SW480, HCT8, and CT26), and murine melanoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a385a0d7c845c36ee314b0ea1da47501
https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01528606

Conjugation of doxorubicin to cell penetrating peptides sensitizes human breast MDA-MB 231 cancer cells to endogenous TRAIL-induced apoptosis

Autor: Jacqueline Bréard, Michel De Waard, Jocelyne Hamelin, Souhir Brahim, Abderraouf Kenani, Sonia Aroui

Publikováno v: Apoptosis
Apoptosis, Springer Verlag, 2009, 14 (11), pp.1352-65. ⟨10.1007/s10495-009-0397-8⟩
Apoptosis, 2009, 14 (11), pp.1352-65. ⟨10.1007/s10495-009-0397-8⟩

International audience; Previous work from our laboratory has shown that coupling doxorubicin (Dox) to cell penetrating peptides (Dox-CPPs) is a good strategy to overcome Dox resistance in MDA-MB 231 breast cancer cells. We also reported that, in con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc9b43dd0ddfd42c3b7ebb17e8da7a4
https://doi.org/10.1007/s10495-009-0397-8

Deglycosylated bleomycin triggers apoptosis in laryngeal carcinoma cells in a caspase and reactive oxygen species independent manner

Autor: Souhir Brahim, Abderraouf Kenani, Ali Bettaieb

Publikováno v: Journal of Oral Pathology & Medicine. 37:352-357

Background: Bleomycin-A2, a member of a family of glycopeptide antibiotics, has potent antitumor activity against a range of lymphomas, head and neck cancer and germ cell tumors. However, little is known about the biologic activity of the carbohydrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::946ec785183b352903a29282950ca530
https://doi.org/10.1111/j.1600-0714.2007.00621.x

Efficient induction of apoptosis by doxorubicin coupled to cell-penetrating peptides compared to unconjugated doxorubicin in the human breast cancer cell line MDA-MB 231

Autor: Abderraouf Kenani, Jacqueline Bréard, Michel De Waard, Sonia Aroui, Souhir Brahim

Publikováno v: Cancer Letters
Cancer Letters, 2009, epub ahead of print. ⟨10.1016/j.canlet.2009.04.044⟩
Cancer Letters, Elsevier, 2009, epub ahead of print. ⟨10.1016/j.canlet.2009.04.044⟩

International audience; Doxorubicin (Dox) is a commonly used drug to treat various types of cancers. Previously, we demonstrated that coupling Dox to cell-penetrating peptides (CPPs) represent a valuable strategy to overcome drug resistance in MDA-MB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a5e10c30bcb3f1965818502782c7e90
https://pubmed.ncbi.nlm.nih.gov/19523755

Role of carbohydrate moiety of bleomycin-A2 in caspase-3 activation and internucleosomal chromatin fragmentation in apoptosis of laryngeal carcinoma cells

Autor: Kaouthar Abid, Souhir Brahim, Abderraouf Kenani

Publikováno v: Cell biology international. 32(2)

Bleomycin (BLM), an antitumor antibiotic, is currently used during anticancer therapy. The therapeutic efficiency of BLM for the treatment of malignant tumors is related to its ability to cleave DNA. However, little is known about the biological acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2f9b51e1320de7f35f5af1e85b23873
https://pubmed.ncbi.nlm.nih.gov/17950632