A New Highlight of Ephedra alata Decne Properties as Potential Adjuvant in Combination with Cisplatin to Induce Cell Death of 4T1 Breast Cancer Cells In Vitro and In Vivo

Autor: Fairouz Sioud, Souheila Amor, Imène ben Toumia, Aida Lahmar, Virginie Aires, Leila Chekir-Ghedira, Dominique Delmas

Publikováno v: Cells, Vol 9, Iss 2, p 362 (2020)

Despite major advances in the last 10 years, whether in terms of prevention or treatment, the 5 year survival rate remains relatively low for a large number of cancers. These therapeutic failures can be the consequence of several factors associated w

Externí odkaz: https://doaj.org/article/6353cf0d99a2457f89262e8d79442f53

Enhanced expression of lmb gene encoding laminin-binding protein in Streptococcus agalactiae strains harboring IS1548 in scpB-lmb intergenic region.

Autor: Rim Al Safadi, Souheila Amor, Geneviève Hery-Arnaud, Barbara Spellerberg, Philippe Lanotte, Laurent Mereghetti, François Gannier, Roland Quentin, Agnès Rosenau

Publikováno v: PLoS ONE, Vol 5, Iss 5, p e10794 (2010)

Group B streptococcus (GBS) is the main cause of neonatal sepsis and meningitis. Bacterial surface proteins play a major role in GBS binding to and invasion of different host surfaces. The scpB and lmb genes, coding for fibronectin-binding and lamini

Externí odkaz: https://doaj.org/article/79219cc9fca34d75942b27fa5b8595e1

Mapping and characterization of G-quadruplexes in the genome of the social amoeba Dictyostelium discoideum

Autor: Aurore Guédin, Souheila Amor, Nicolas J. Tourasse, Amina Bedrat, Jean-Louis Mergny, Hussein Fayyad-Kazan, Laurent Lacroix, Mona Saad, Geneviève Pratviel

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2019, 47 (9), pp.4363-4374. ⟨10.1093/nar/gkz196⟩
Nucleic Acids Research, 2019, 47 (9), pp.4363-4374. ⟨10.1093/nar/gkz196⟩

International audience; G-quadruplexes (G4) are non-canonical DNA and/or RNA secondary structures formed in guanine-rich regions. Given their over-representation in specific regions in the genome such as promoters and telomeres, they are likely to pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e25295e5138f2fdc266f1468cc9176a3
https://hal.archives-ouvertes.fr/hal-02140699

Identification of Three-Way DNA Junction Ligands through Screening of Chemical Libraries and Validation by Complementary in Vitro Assays

Autor: Anton Granzhan, Murielle Chavarot-Kerlidou, David Monchaud, Charles H. Devillers, Katerina Duskova, Coralie Caron, Nicolas Queyriaux, Sébastien Britton, Souheila Amor, Dominique Delmas, Marie-José Penouilh, Guillaume de Robillard, Marie-Paule Teulade-Fichou, Marie Gaschard, Jérémy Lamarche, Bruno Therrien

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2019, 62 (9), pp.4456-4466. ⟨10.1021/acs.jmedchem.8b01978⟩
Journal of Medicinal Chemistry, American Chemical Society, 2019, 62 (9), pp.4456-4466. ⟨10.1021/acs.jmedchem.8b01978⟩

International audience; The human genome is replete with repetitive DNA sequences that can fold into thermodynamically stable secondary structures such as hairpins and quadruplexes. Cellular enzymes exist to cope with these structures whose stable ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad463417f93cfa50d7c36926dd1ffd1c
https://doi.org/10.1021/acs.jmedchem.8b01978

Gold(I)-Coumarin-Caffeine-Based Complexes as New Potential Anti-Inflammatory and Anticancer Trackable Agents

Autor: Jean-Louis Connat, Benoît Bertrand, Souheila Amor, Pierre Le Gendre, Florian Chotard, Ewen Bodio, Catherine Paul, Ali Bettaieb, Philippe Richard, Audrey Trommenschlager

Publikováno v: ChemMedChem. 13(22)

Three new gold(I)-coumarin-based trackable therapeutic complexes and two non-trackable analogues have been synthesised and fully characterised. They all display anti-proliferative properties on several types of cancer cell lines, including those of c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da9076c34d6bc41273657d8e1b3792f3
https://pubmed.ncbi.nlm.nih.gov/30203922