Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Soufyan Jerhaoui"'
Autor:
Ann Vos, Lieve Lammens, Richard Alexander, Frederik J. R. Rombouts, Michel Surkyn, Kenji Morimoto, Laurent Leclercq, Nigel Austin, Koichi Tsubone, Tatsuhiko Ueno, Michel Anna Jozef De Cleyn, Deborah Dhuyvetter, Ken-ichi Kusakabe, Ard Teisman, Diederik Moechars, Tom Jacobs, An Van Den Bergh, Hirokazu Sumiyoshi, Herman Borghys, Shunsuke Einaru, Soufyan Jerhaoui, Brian Joel Hrupka, Harrie J.M. Gijsen
Publikováno v:
Journal of Medicinal Chemistry. 64:14175-14191
The discovery of a novel 2-aminotetrahydropyridine class of BACE1 inhibitors is described. Their pKa and lipophilicity were modulated by a pending sulfonyl group, while good permeability and brain penetration were achieved via intramolecular hydrogen
Publikováno v:
C-H Activation for Asymmetric Synthesis
Publikováno v:
The Journal of organic chemistry. 87(4)
MCL-1 is an attractive target for cancer therapy. We recently discovered highly potent and selective MCL-1 inhibitors containing a fluoroalkene fragment for which an efficient route to the main chiral gem-fluoro-BPin fragment was needed. The key step
Autor:
David Lebœuf, Lucile Marin, Emmanuelle Schulz, Joanna Wencel-Delord, Françoise Colobert, Emilie Kolodziej, Vincent Gandon, Régis Guillot, Soufyan Jerhaoui
Publikováno v:
Advanced Synthesis and Catalysis
Advanced Synthesis and Catalysis, Wiley-VCH Verlag, 2021, 363 (17), pp.4277-4282. ⟨10.1002/adsc.202100848⟩
Advanced Synthesis and Catalysis, 2021, 363 (17), pp.4277-4282. ⟨10.1002/adsc.202100848⟩
Advanced Synthesis and Catalysis, Wiley-VCH Verlag, 2021, 363 (17), pp.4277-4282. ⟨10.1002/adsc.202100848⟩
Advanced Synthesis and Catalysis, 2021, 363 (17), pp.4277-4282. ⟨10.1002/adsc.202100848⟩
International audience; The development of a novel stereoselective aza-Piancatelli reaction to access 4aminocyclopentenones is reported. This transformation relies on the use of chiral o-sulfinyl anilines as chiral inductors to afford the targeted pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23fc939042f659a0873f2669e9897efe
https://hal.archives-ouvertes.fr/hal-03379917/file/ASC-sulfoxyde-07072021.pdf
https://hal.archives-ouvertes.fr/hal-03379917/file/ASC-sulfoxyde-07072021.pdf
Publikováno v:
ACS Catalysis
ACS Catalysis, American Chemical Society, 2019, 9 (3), pp.2532-2542. ⟨10.1021/acscatal.8b04946⟩
ACS Catalysis, American Chemical Society, 2019, 9 (3), pp.2532-2542. ⟨10.1021/acscatal.8b04946⟩
Although chiral sulfoxides are important motifs in medicinal chemistry and asymmetric synthesis, design and applications of sulfoxide ligands are still limited, in particular in the context of asym...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e193b6279ecec1bbc3f75a4032d07e0
https://hal.archives-ouvertes.fr/hal-02158209
https://hal.archives-ouvertes.fr/hal-02158209
Autor:
James Rae, Françoise Colobert, Soufyan Jerhaoui, Sabine Choppin, Joanna Wencel-Delord, Johanna Frey
Publikováno v:
ACS Catalysis
ACS Catalysis, American Chemical Society, 2018, 8 (4), pp.2805-2809. ⟨10.1021/acscatal.7b04343⟩
ACS Catalysis, American Chemical Society, 2018, 8 (4), pp.2805-2809. ⟨10.1021/acscatal.7b04343⟩
Axially chiral C–N compounds are an emerging but scarcely investigated class of stereogenic molecules with potential applications as biologically active scaffolds and chiral ligands. The synthesis of these compounds is extremely challenging, and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ec56a05b82957d78c2c7e5e9ef71f6
https://hal.archives-ouvertes.fr/hal-02161671
https://hal.archives-ouvertes.fr/hal-02161671
Publikováno v:
Organic Chemistry Frontiers
Organic Chemistry Frontiers, Royal Society of Chemistry, 2018, 5, pp.409-414. ⟨10.1039/C7QO00737J⟩
Organic Chemistry Frontiers, Royal Society of Chemistry, 2018, 5, pp.409-414. ⟨10.1039/C7QO00737J⟩
A rapid and efficient synthesis of hoshinolactam, an enantiopure cyclopropane containing natural product, is described. This strategy is based on stereospecific C(sp3)–H activation via unprecedented olefination on the cyclopropane core. The use of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be244b561592a7d1197d619bea4dd1d2
https://hal.archives-ouvertes.fr/hal-02177419
https://hal.archives-ouvertes.fr/hal-02177419
Publikováno v:
Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2017, 23, pp.15594-15600. ⟨10.1002/chem.201703274⟩
Chemistry-A European Journal, Wiley-VCH Verlag, 2017, 23, pp.15594-15600. ⟨10.1002/chem.201703274⟩
Stereoselective functionalization of aliphatic C-H bonds presents a great challenge. Following this target, we disclose herein an original strategy towards direct arylation of aliphatic chains at ß-methylene position based on a use of amide-sulfoxid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::742d8d231f751966326b1ec5d635329b
https://hal.archives-ouvertes.fr/hal-02177422
https://hal.archives-ouvertes.fr/hal-02177422
Autor:
Joanna Wencel-Delord, Soufyan Jerhaoui, Françoise Colobert, Clémence Rose, Jean-Pierre Djukic, Faouzi Chahdoura
Publikováno v:
Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2016, 22 (48), pp.17397-17406. ⟨10.1002/chem.201603507⟩
Chemistry-A European Journal, 2016, 22 (48), pp.17397-17406. ⟨10.1002/chem.201603507⟩
Chemistry-A European Journal, Wiley-VCH Verlag, 2016, 22 (48), pp.17397-17406. ⟨10.1002/chem.201603507⟩
Chemistry-A European Journal, 2016, 22 (48), pp.17397-17406. ⟨10.1002/chem.201603507⟩
An original and recyclable chiral bidentate aniline-sulfoxide-based directing group has been developed. This auxiliary allows challenging stereoselective Pd-catalyzed direct functionalization of small cycloalkanes through C-aryl and C-alkyl bond form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19bddd2b53c304ebaf01f7a7ce040de9
https://hal.archives-ouvertes.fr/hal-02410798
https://hal.archives-ouvertes.fr/hal-02410798
Autor:
Soufyan, Jerhaoui, Faouzi, Chahdoura, Clémence, Rose, Jean-Pierre, Djukic, Joanna, Wencel-Delord, Françoise, Colobert
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 22(48)
An original and recyclable chiral bidentate aniline-sulfoxide-based directing group has been developed. This auxiliary allows challenging stereoselective Pd-catalyzed direct functionalization of small cycloalkanes through C-aryl and C-alkyl bond form