Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Soufiane Boumahdi"'
Autor:
Antonina V. Kurtova, Melanie Heinlein, Simon Haas, Lars Velten, Gerrit J. P. Dijkgraaf, Elaine E. Storm, Noelyn M. Kljavin, Soufiane Boumahdi, Patricia Himmels, Aurelie Herault, Andrew Mancini, Hartmut Koeppen, Monique Dail, Qingxiang Yan, Jianhuan Zhang, Ute Koch, Freddy Radtke, Zora Modrusan, Ciara Metcalfe, Robert Piskol, Frederic J. de Sauvage
Self-renewal and differentiation of stem and progenitor cells are tightly regulated to ensure tissue homeostasis. This regulation is enabled both remotely by systemic circulating cues, such as cytokines and hormones, and locally by various niche-conf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b308255afe28c772497cb21827be407c
http://edoc.mdc-berlin.de/21971/2/21971suppl.pdf
http://edoc.mdc-berlin.de/21971/2/21971suppl.pdf
Publikováno v:
Nature Reviews Drug Discovery. 19:39-56
The success of targeted therapies in cancer treatment has been impeded by various mechanisms of resistance. Besides the acquisition of resistance-conferring genetic mutations, reversible mechanisms that lead to drug tolerance have emerged. Plasticity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9e05c24dad8fc69a36cab49e317a5b3
https://doi.org/10.1038/s41573-019-0044-1
https://doi.org/10.1038/s41573-019-0044-1
Autor:
Frederic J. de Sauvage, Stephen E. Gould, Gerrit J. P. Dijkgraaf, Franklin Peale, Soufiane Boumahdi, Brian Biehs, Bruno Alicke, Robert Piskol
Publikováno v:
Nature. 562:429-433
Despite the efficacy of Hedgehog pathway inhibitors in the treatment of basal cell carcinoma (BCC)1, residual disease persists in some patients and may contribute to relapse when treatment is discontinued2. Here, to study the effect of the Smoothened
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f27efd049b599d0ab2b873636c5fa4c1
https://doi.org/10.1038/s41586-018-0596-y
https://doi.org/10.1038/s41586-018-0596-y
Autor:
Ievgenia Pastushenko, Federico Sopena, Virginie Moers, Audrey Brisebarre, Angel Lanas, Soufiane Boumahdi, Cédric Blanpain, Isabelle Salmon, Marco Fioramonti, Cédric Balsat, Jean-Christophe Marine, Youri Sokolow, Sarah De Clercq, Panagiota A. Sotiropoulou, Samuel Scozzaro, Alejandro Sifrim, Alexandra Van Keymeulen, Florian De Cock, Christine Dubois, Tatiana Revenco, Esmeralda Minguijón, Thierry Voet, Daniel Brown, Nicky D'Haene, Sophie Lemaire
Publikováno v:
Nature. 556:463-468
In cancer, the epithelial-to-mesenchymal transition (EMT) is associated with tumour stemness, metastasis and resistance to therapy. It has recently been proposed that, rather than being a binary process, EMT occurs through distinct intermediate state
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a960807e419e524687a9ba4aaa5404b6
https://doi.org/10.1038/s41586-018-0040-3
https://doi.org/10.1038/s41586-018-0040-3
Autor:
Rui Yi, Audrey Brisebarre, Agnieszka Checinska, Alizée Vercauteren Drubbel, Erwin Nkusi, Soufiane Boumahdi, Sandrine Lenglez, Christine Dubois, Michael Devos, Benjamin Beck, Mathilde Latil, Cédric Blanpain, Li Wang, Dany Nassar, Wim Declercq
Publikováno v:
Cell stem cell, 20 (2
Epithelial to mesenchymal transition (EMT) in cancer cells has been associated with metastasis, stemness, and resistance to therapy. Some tumors undergo EMT while others do not, which may reflect intrinsic properties of their cell of origin. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ebd28d06492300f594cf5f17a53a26
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/241437
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/241437
Autor:
Christine Dubois, Erwin Nkusi, Sandrine Rorive, Soufiane Boumahdi, Gregory Driessens, Cédric Blanpain, François Fuks, Isabelle Salmon, Benjamin Delatte, Sylvain Brohée, Benjamin Beck, Amélie Caauwe, Gaëlle Lapouge, Marie Le Mercier, Véronique Del Marmol, Sandrine Lenglez, Dany Nassar
Publikováno v:
Nature. 511:246-250
Cancer stem cells (CSCs) have been reported in various cancers, including in skin squamous-cell carcinoma (SCC). The molecular mechanisms regulating tumour initiation and stemness are still poorly characterized. Here we find that Sox2, a transcriptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01c67bf00ebeb757dea7ba18cc99bfd9
https://doi.org/10.1038/nature13305
https://doi.org/10.1038/nature13305
Autor:
Soufiane, Boumahdi, Cédric, Blanpain
Publikováno v:
Science (New York, N.Y.). 351(6272)
The “cancerized field” concept posits that cells in a given tissue share an oncogenic mutation or insult and are thus cancer-prone, yet only discreet clones within the field initiate tumors. Nearly all benign nevi carry oncogenic BRAFV600E mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9648eaa8fd427c052d1fc54513b164ef
https://pubmed.ncbi.nlm.nih.gov/26823433
https://pubmed.ncbi.nlm.nih.gov/26823433
Autor:
Cédric Blanpain, Soufiane Boumahdi
Publikováno v:
Science. 351:453-454
Cancer arises through mutations that transform normal cells into cells that proliferate in an uncontrolled manner, form a tumor, invade the underlying tissue, and then metastasize to distant organs ( 1 ). Although the genetic events required to induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4773df7f503d022f8fd5f5b3c6d49f90
https://doi.org/10.1126/science.aad9670
https://doi.org/10.1126/science.aad9670