Design, synthesis and in vitro cell-free/cell-based biological evaluations of novel ERCC1-XPF inhibitors targeting DNA repair pathway.

Autor: Elmenoufy AH; Department of Chemistry, University of Alberta, Edmonton, Alberta, T6G 2G2, Canada; Department of Pharmaceutical Chemistry, College of Pharmacy, Misr University for Science and Technology, 6th of October City, P.O. Box: 77, Egypt., Gentile F; Department of Physics, University of Alberta, Edmonton, Alberta, T6G 2E1, Canada., Jay D; Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, T6G 1Z2, Canada., Karimi-Busheri F; Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, T6G 1Z2, Canada., Yang X; Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, T6G 1Z2, Canada., Soueidan OM; Department of Chemistry, University of Alberta, Edmonton, Alberta, T6G 2G2, Canada., Mani RS; Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, T6G 1Z2, Canada., Ciniero G; Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Torino, 10129, Italy; Università di Torino, Torino, 10124, Italy., Tuszynski JA; Department of Physics, University of Alberta, Edmonton, Alberta, T6G 2E1, Canada; Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, T6G 1Z2, Canada., Weinfeld M; Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, T6G 1Z2, Canada., West FG; Department of Chemistry, University of Alberta, Edmonton, Alberta, T6G 2G2, Canada. Electronic address: fwest@ualberta.ca.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2020 Oct 15; Vol. 204, pp. 112658. Date of Electronic Publication: 2020 Jul 22.

Molecular Imaging of GLUT1 and GLUT5 in Breast Cancer: A Multitracer Positron Emission Tomography Imaging Study in Mice.

Autor: Wuest M; Departments of Oncology and Cross Cancer Institute (M.Wu., I.H., V.B., D.G., A.M., D.K., M.Wa., F.Wu.), Chemistry (O.-M.S., F.We.), and Physiology (B.T., O.-M.S., C.C.), University of Alberta, Edmonton, Alberta, Canada mwuest@ualberta.ca., Hamann I; Departments of Oncology and Cross Cancer Institute (M.Wu., I.H., V.B., D.G., A.M., D.K., M.Wa., F.Wu.), Chemistry (O.-M.S., F.We.), and Physiology (B.T., O.-M.S., C.C.), University of Alberta, Edmonton, Alberta, Canada., Bouvet V; Departments of Oncology and Cross Cancer Institute (M.Wu., I.H., V.B., D.G., A.M., D.K., M.Wa., F.Wu.), Chemistry (O.-M.S., F.We.), and Physiology (B.T., O.-M.S., C.C.), University of Alberta, Edmonton, Alberta, Canada., Glubrecht D; Departments of Oncology and Cross Cancer Institute (M.Wu., I.H., V.B., D.G., A.M., D.K., M.Wa., F.Wu.), Chemistry (O.-M.S., F.We.), and Physiology (B.T., O.-M.S., C.C.), University of Alberta, Edmonton, Alberta, Canada., Marshall A; Departments of Oncology and Cross Cancer Institute (M.Wu., I.H., V.B., D.G., A.M., D.K., M.Wa., F.Wu.), Chemistry (O.-M.S., F.We.), and Physiology (B.T., O.-M.S., C.C.), University of Alberta, Edmonton, Alberta, Canada., Trayner B; Departments of Oncology and Cross Cancer Institute (M.Wu., I.H., V.B., D.G., A.M., D.K., M.Wa., F.Wu.), Chemistry (O.-M.S., F.We.), and Physiology (B.T., O.-M.S., C.C.), University of Alberta, Edmonton, Alberta, Canada., Soueidan OM; Departments of Oncology and Cross Cancer Institute (M.Wu., I.H., V.B., D.G., A.M., D.K., M.Wa., F.Wu.), Chemistry (O.-M.S., F.We.), and Physiology (B.T., O.-M.S., C.C.), University of Alberta, Edmonton, Alberta, Canada., Krys D; Departments of Oncology and Cross Cancer Institute (M.Wu., I.H., V.B., D.G., A.M., D.K., M.Wa., F.Wu.), Chemistry (O.-M.S., F.We.), and Physiology (B.T., O.-M.S., C.C.), University of Alberta, Edmonton, Alberta, Canada., Wagner M; Departments of Oncology and Cross Cancer Institute (M.Wu., I.H., V.B., D.G., A.M., D.K., M.Wa., F.Wu.), Chemistry (O.-M.S., F.We.), and Physiology (B.T., O.-M.S., C.C.), University of Alberta, Edmonton, Alberta, Canada., Cheeseman C; Departments of Oncology and Cross Cancer Institute (M.Wu., I.H., V.B., D.G., A.M., D.K., M.Wa., F.Wu.), Chemistry (O.-M.S., F.We.), and Physiology (B.T., O.-M.S., C.C.), University of Alberta, Edmonton, Alberta, Canada., West F; Departments of Oncology and Cross Cancer Institute (M.Wu., I.H., V.B., D.G., A.M., D.K., M.Wa., F.Wu.), Chemistry (O.-M.S., F.We.), and Physiology (B.T., O.-M.S., C.C.), University of Alberta, Edmonton, Alberta, Canada., Wuest F; Departments of Oncology and Cross Cancer Institute (M.Wu., I.H., V.B., D.G., A.M., D.K., M.Wa., F.Wu.), Chemistry (O.-M.S., F.We.), and Physiology (B.T., O.-M.S., C.C.), University of Alberta, Edmonton, Alberta, Canada.

Publikováno v: Molecular pharmacology [Mol Pharmacol] 2018 Feb; Vol. 93 (2), pp. 79-89. Date of Electronic Publication: 2017 Nov 15.

Fluorescent Hexose Conjugates Establish Stringent Stereochemical Requirement by GLUT5 for Recognition and Transport of Monosaccharides.

Autor: Soueidan OM; Department of Chemistry, University of Alberta , 11227 Saskatchewan Drive, Edmonton, Alberta, Canada T6G 2G2.; Department of Physiology, University of Alberta , 7-55 Medical Sciences Building, Edmonton, Alberta, Canada T6G 2H7., Scully TW; Department of Chemistry, University of Alberta , 11227 Saskatchewan Drive, Edmonton, Alberta, Canada T6G 2G2., Kaur J; Department of Oncology, University of Alberta , Cross Cancer Institute, Edmonton, Alberta, Canada T6G 1Z2., Panigrahi R; Department of Biochemistry, University of Alberta , 451 Medical Sciences Building, Edmonton, Alberta, Canada T6G 2H7., Belovodskiy A; Department of Chemistry, University of Alberta , 11227 Saskatchewan Drive, Edmonton, Alberta, Canada T6G 2G2., Do V; Department of Physiology, University of Alberta , 7-55 Medical Sciences Building, Edmonton, Alberta, Canada T6G 2H7., Matier CD; Department of Chemistry, University of Alberta , 11227 Saskatchewan Drive, Edmonton, Alberta, Canada T6G 2G2., Lemieux MJ; Department of Biochemistry, University of Alberta , 451 Medical Sciences Building, Edmonton, Alberta, Canada T6G 2H7., Wuest F; Department of Oncology, University of Alberta , Cross Cancer Institute, Edmonton, Alberta, Canada T6G 1Z2., Cheeseman C; Department of Physiology, University of Alberta , 7-55 Medical Sciences Building, Edmonton, Alberta, Canada T6G 2H7., West FG; Department of Chemistry, University of Alberta , 11227 Saskatchewan Drive, Edmonton, Alberta, Canada T6G 2G2.

Publikováno v: ACS chemical biology [ACS Chem Biol] 2017 Apr 21; Vol. 12 (4), pp. 1087-1094. Date of Electronic Publication: 2017 Mar 02.

New fluorinated fructose analogs as selective probes of the hexose transporter protein GLUT5.

Autor: Soueidan OM; Department of Chemistry, 11227 Saskatchewan Drive University of Alberta, Edmonton, AB, Canada T6G 2G2. frederick.west@ualberta.ca., Trayner BJ, Grant TN, Henderson JR, Wuest F, West FG, Cheeseman CI

Publikováno v: Organic & biomolecular chemistry [Org Biomol Chem] 2015 Jun 21; Vol. 13 (23), pp. 6511-21. Date of Electronic Publication: 2015 May 15.

Automated synthesis and dosimetry of 6-deoxy-6-[(18)F]fluoro-D-fructose (6-[(18)F]FDF): a radiotracer for imaging of GLUT5 in breast cancer.

Autor: Bouvet V; Department of Oncology, University of Alberta Edmonton, AB - T6G 1Z2, Canada., Jans HS; Department of Oncology, University of Alberta Edmonton, AB - T6G 1Z2, Canada., Wuest M; Department of Oncology, University of Alberta Edmonton, AB - T6G 1Z2, Canada., Soueidan OM; Department of Chemistry,University of Alberta Edmonton, AB - T6G 1Z2, Canada., Mercer J; Department of Oncology, University of Alberta Edmonton, AB - T6G 1Z2, Canada., McEwan AJ; Department of Oncology, University of Alberta Edmonton, AB - T6G 1Z2, Canada., West FG; Department of Chemistry,University of Alberta Edmonton, AB - T6G 1Z2, Canada., Cheeseman CI; Department of Physiology, University of Alberta Edmonton, AB - T6G 1Z2, Canada., Wuest F; Department of Oncology, University of Alberta Edmonton, AB - T6G 1Z2, Canada.

Publikováno v: American journal of nuclear medicine and molecular imaging [Am J Nucl Med Mol Imaging] 2014 Apr 25; Vol. 4 (3), pp. 248-59. Date of Electronic Publication: 2014 Apr 25 (Print Publication: 2014).