Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Souad ElKhattabi"'
Autor:
Marwa Manachou, Ossama Daoui, Oussama Abchir, Rahma Dahmani, Souad Elkhattabi, Abdelouahid Samadi, Salah Belaidi, Samir Chtita
Publikováno v:
Scientific African, Vol 23, Iss , Pp e02078- (2024)
Merging Density Functional Theory (DFT) with the Quantitative Structure-Activity Relationship (2D/3D-QSAR) modeling represents a promising avenue for exploring antibacterial activity and discovering potential drugs effective against both gram-positiv
Externí odkaz:
https://doaj.org/article/b6557d26bc8f4ab880b72795395ae46f
Autor:
Rachid Haloui, Kaouakeb ElKhattabi, Khaoula Mkhayar, Ossama Daoui, Samir Chtita, Amal Haoudi, Souad Elkhattabi
Publikováno v:
Scientific African, Vol 23, Iss , Pp e01990- (2024)
Histone deacetylase (HDAC) dysregulation plays an important role in cancer progression and is an important therapeutic target for anticancer drug development. A series of molecules derived from styrylpyridine have HDAC inhibitory activity for the tre
Externí odkaz:
https://doaj.org/article/14c25473a8cd4dd298cd7d749fed1096
Autor:
Said El Rhabori, Abdellah El Aissouq, Ossama Daoui, Souad Elkhattabi, Samir Chtita, Fouad Khalil
Publikováno v:
Heliyon, Vol 10, Iss 3, Pp e24551- (2024)
Cervical cancer is a major health problem of women. Hormone therapy, via aromatase inhibition, has been proposed as a promising way of blocking estrogen production as well as treating the progression of estrogen-dependent cancer. To overcome the chal
Externí odkaz:
https://doaj.org/article/b36384da87f04d5d9e84ed3eb32cad03
Autor:
Oussama Abchir, Ossama Daoui, Hassan Nour, Imane Yamari, Souad Elkhattabi, Abdelkbir Errougui, Samir Chtita
Publikováno v:
Scientific African, Vol 21, Iss , Pp e01745- (2023)
Diabetes Mellitus is one of the deadliest diseases in the world, while the current medications against this disease like acarbose represent many side effects such as diarrhea and abdominal discomfort. Many studies based on natural plants used in trad
Externí odkaz:
https://doaj.org/article/98df3d1664924ba0be9e6d7c57f2d300
Autor:
Abdelmoula El Abbouchi, Khaoula Mkhayar, Souad Elkhattabi, Nabil El Brahmi, Marie-Aude Hiebel, Jérôme Bignon, Gérald Guillaumet, Franck Suzenet, Saïd El Kazzouli
Publikováno v:
Molecules, Vol 29, Iss 7, p 1437 (2024)
In the present work, the synthesis of new ethacrynic acid (EA) derivatives containing nitrogen heterocyclic, urea, or thiourea moieties via efficient and practical synthetic procedures was reported. The synthesised compounds were screened for their a
Externí odkaz:
https://doaj.org/article/fdf8dde43bea4853a0b9e3e4ad474c90
Autor:
Khaoula Mkhayar, Ossama Daoui, Rachid Haloui, Kaouakeb Elkhattabi, Abdelmoula Elabbouchi, Samir Chtita, Abdelouahid Samadi, Souad Elkhattabi
Publikováno v:
Molecules, Vol 29, Iss 2, p 426 (2024)
In this study, using the Comparative Molecular Field Analysis (CoMFA) approach, the structure-activity relationship of 33 small quinoline-based compounds with biological anti-gastric cancer activity in vitro was analyzed in 3D space. Once the 3D geom
Externí odkaz:
https://doaj.org/article/fbaec9c3b7d44b16ae46aa631082407a
Publikováno v:
Heliyon, Vol 9, Iss 4, Pp e15545- (2023)
This study examines the potential of Cannabis sativa L. plants to be repurposed as therapeutic agents for cancer treatment through designing of hybrid Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). A set of 50 phytochemicals
Externí odkaz:
https://doaj.org/article/9d2ccb4610824c99a6ce07bf6ffc9b07
Publikováno v:
Heliyon, Vol 8, Iss 12, Pp e11991- (2022)
Butyrylcholinesterase is an acetylcholine-degrading enzyme involved in the memorization process, which is becoming an interesting target for the symptomatic treatment of Alzheimer's disease. In the present investigation, the structure–activity rela
Externí odkaz:
https://doaj.org/article/f7cfc66002624ce0878994a7975d772a
Publikováno v:
Medical Sciences Forum, Vol 14, Iss 1, p 106 (2022)
In this work, we investigated the quantitative relationship between biological activity against non-small cell lung cancer (NSCLC) and the molecular structure of a series of 38 cyclohexane-1,3-dione-dimidone derivatives. For this purpose, molecular d
Externí odkaz:
https://doaj.org/article/4b7e3677b70045d3b734460cb955c56c
Autor:
Ossama Daoui, Souad Elkhattabi, Samir Chtita, Rachida Elkhalabi, Hsaine Zgou, Adil Touimi Benjelloun
Publikováno v:
Heliyon, Vol 7, Iss 7, Pp e07463- (2021)
A quantitative structure-activity relationship (QSAR) study is performed on 48 novel 4,5,6,7-tetrahydrobenzo[D]-thiazol-2 derivatives as anticancer agents capable of inhibiting c-Met receptor tyrosine kinase. The present study is conducted using mult
Externí odkaz:
https://doaj.org/article/34a2723c3f474e45987ced3dfda343b8