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pro vyhledávání: '"Sotolongo Bellón J"'
Engineered IL-10 variants elicit potent immuno-modulatory activities at therapeutic low ligand doses
Autor:
Christophe Ferrand, Sotolongo Bellón J, Adeline Cozzani, Stephan Wilmes, Suman Mitra, Mark R. Walter, Jacob Piehler, Ignacio Moraga, Walid Warda, Claire Gorby, Elizabeth Pohler, Paul K. Fyfe
Interleukin-10 is a dimeric cytokine with both immune-suppressive and immune-stimulatory activities. Despite its immuno-modulatory potential, IL-10-based therapies have shown only marginal benefits in the clinic. Here we have explored whether the sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1bfa7aaf412082fb2b275394e442713
https://doi.org/10.1101/2020.03.10.985069
https://doi.org/10.1101/2020.03.10.985069
Akademický článek
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Akademický článek
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Autor:
Shih HP; Laboratory of Human Immunology and Infectious Disease, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan., Ding JY; Laboratory of Human Immunology and Infectious Disease, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan., Sotolongo Bellón J; Division of Biophysics, Department of Biology, University of Osnabruck, Osnabruck, Germany., Lo YF; Laboratory of Human Immunology and Infectious Disease, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan., Chung PH; Elixiron Immunotherapeutics, Taipei, Taiwan., Ting HT; Laboratory of Human Immunology and Infectious Disease, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan., Peng JJ; Laboratory of Human Immunology and Infectious Disease, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan., Wu TY; Laboratory of Human Immunology and Infectious Disease, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan., Lin CH; Laboratory of Human Immunology and Infectious Disease, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan., Lo CC; Laboratory of Human Immunology and Infectious Disease, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan., Lin YN; Laboratory of Human Immunology and Infectious Disease, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan., Yeh CF; Laboratory of Human Immunology and Infectious Disease, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan.; Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan., Chen JB; Genomics Research Center, Academia Sinica, Taipei, Taiwan., Wu TS; Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan.; Chang Gung University College of Medicine, Taoyuan, Taiwan., Liu YM; Division of Infectious Diseases, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan., Kuo CY; Laboratory of Human Immunology and Infectious Disease, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan.; Division of Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan., Wang SY; Laboratory of Human Immunology and Infectious Disease, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan.; Division of General Surgery, Department of Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan., Tu KH; Laboratory of Human Immunology and Infectious Disease, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan.; Chang Gung University College of Medicine, Taoyuan, Taiwan.; Kidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Taoyuan, Taiwan., Ng CY; Laboratory of Human Immunology and Infectious Disease, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan.; Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan., Lei WT; Laboratory of Human Immunology and Infectious Disease, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan.; Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu, Taiwan., Tsai YH; Laboratory of Host-Microbe Interactions and Cell Dynamics, Institute of Microbiology and Immunology, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan., Chen JH; Genomics Research Center, Academia Sinica, Taipei, Taiwan., Chuang YT; Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan., Huang JY; Elixiron Immunotherapeutics, Taipei, Taiwan., Rey FA; Structural Virology Unit, Department of Virology, Institut Pasteur, Paris, France., Chen HK; Elixiron Immunotherapeutics, Taipei, Taiwan., Chang TW; Genomics Research Center, Academia Sinica, Taipei, Taiwan., Piehler J; Division of Biophysics, Department of Biology, University of Osnabruck, Osnabruck, Germany., Chi CY; Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.; School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan., Ku CL; Laboratory of Human Immunology and Infectious Disease, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan.; Department of Nephrology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.; Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan.
Publikováno v:
The Journal of experimental medicine [J Exp Med] 2022 Sep 05; Vol. 219 (9). Date of Electronic Publication: 2022 Jul 14.
Autor:
Gorby C; Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee DD15EH, UK., Sotolongo Bellón J; Department of Biology and Center for Cellular Nanoanalytics (CellNanOs), University of Osnabrück, Barbarastraße 11, 49076 Osnabrück, Germany., Wilmes S; Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee DD15EH, UK., Warda W; Université Bourgogne Franche-Comté, INSERM, EFS BFC, UMR1098, RIGHT Interactions Greffon-Hôte-Tumeur/Ingénierie Cellulaire et Génique, F-25000 Besançon, France., Pohler E; Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee DD15EH, UK., Fyfe PK; Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee DD15EH, UK., Cozzani A; Université de Lille, INSERM UMR1277 CNRS UMR9020-CANTHER and Institut pour la Recherche sur le Cancer de Lille (IRCL), Lille, France., Ferrand C; Université Bourgogne Franche-Comté, INSERM, EFS BFC, UMR1098, RIGHT Interactions Greffon-Hôte-Tumeur/Ingénierie Cellulaire et Génique, F-25000 Besançon, France., Walter MR; Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35243, USA., Mitra S; Université de Lille, INSERM UMR1277 CNRS UMR9020-CANTHER and Institut pour la Recherche sur le Cancer de Lille (IRCL), Lille, France., Piehler J; Department of Biology and Center for Cellular Nanoanalytics (CellNanOs), University of Osnabrück, Barbarastraße 11, 49076 Osnabrück, Germany., Moraga I; Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee DD15EH, UK. imoragagonzalez@dundee.ac.uk.
Publikováno v:
Science signaling [Sci Signal] 2020 Sep 15; Vol. 13 (649). Date of Electronic Publication: 2020 Sep 15.