Lethal COVID-19 associates with RAAS-induced inflammation for multiple organ damage including mediastinal lymph nodes.

Autor: Topper MJ; COVID-19 International Research Team, Medford, MA 02155.; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287., Guarnieri JW; COVID-19 International Research Team, Medford, MA 02155.; The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104., Haltom JA; COVID-19 International Research Team, Medford, MA 02155.; The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104., Chadburn A; Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065., Cope H; School of Medicine, University of Nottingham, Derby DE22 3DT, United Kingdom., Frere J; Icahn School of Medicine, Mount Sinai, New York, NY 10023., An J; COVID-19 International Research Team, Medford, MA 02155.; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287., Borczuk A; Weill Cornell Medicine, New York, NY 10065., Sinha S; Weill Cornell Medicine, New York, NY 10065., Kim J; Weill Cornell Medicine, New York, NY 10065., Park J; Weill Cornell Medicine, New York, NY 10065., Butler D; Weill Cornell Medicine, New York, NY 10065., Meydan C; Weill Cornell Medicine, New York, NY 10065., Foox J; Weill Cornell Medicine, New York, NY 10065., Bram Y; Weill Cornell Medicine, New York, NY 10065., Richard SA; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University, Bethesda, MD 20814.; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD 20817., Epsi NJ; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University, Bethesda, MD 20814.; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD 20817., Agan B; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University, Bethesda, MD 20814.; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD 20817., Chenoweth JG; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD 20817., Simons MP; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University, Bethesda, MD 20814., Tribble D; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University, Bethesda, MD 20814., Burgess T; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University, Bethesda, MD 20814., Dalgard C; Department of Anatomy, Physiology & Genetics, Uniformed Services University, Bethesda, MD 20814., Heise MT; University of North Carolina, Chapel Hill, NC 27599., Moorman NJ; University of North Carolina, Chapel Hill, NC 27599., Baxter VK; University of North Carolina, Chapel Hill, NC 27599., Madden EA; University of North Carolina, Chapel Hill, NC 27599., Taft-Benz SA; University of North Carolina, Chapel Hill, NC 27599., Anderson EJ; University of North Carolina, Chapel Hill, NC 27599., Sanders WA; University of North Carolina, Chapel Hill, NC 27599., Dickmander RJ; University of North Carolina, Chapel Hill, NC 27599., Beigel K; COVID-19 International Research Team, Medford, MA 02155.; The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Department of Biomedical and Health, The Children's Hospital of Philadelphia, Philadelphia, PA 19104., Widjaja GA; COVID-19 International Research Team, Medford, MA 02155.; The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104., Janssen KA; COVID-19 International Research Team, Medford, MA 02155.; The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104., Lie T; COVID-19 International Research Team, Medford, MA 02155.; The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104., Murdock DG; COVID-19 International Research Team, Medford, MA 02155.; The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104., Angelin A; COVID-19 International Research Team, Medford, MA 02155.; The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104., Soto Albrecht YE; COVID-19 International Research Team, Medford, MA 02155.; The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; The University of Pennsylvania, Philadelphia, PA 19104., Olali AZ; COVID-19 International Research Team, Medford, MA 02155.; The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104., Cen Z; COVID-19 International Research Team, Medford, MA 02155.; The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104., Dybas J; COVID-19 International Research Team, Medford, MA 02155.; The Children's Hospital of Philadelphia, Philadelphia, PA 19104., Priebe W; COVID-19 International Research Team, Medford, MA 02155.; University of Texas Monroe Dunaway Anderson Cancer Center, Houston, TX 77030., Emmett MR; COVID-19 International Research Team, Medford, MA 02155.; University of Texas Medical Branch, Galveston, TX 77555., Best SM; COVID-19 International Research Team, Medford, MA 02155.; Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, National Institute of Allergy and Infectious Diseases, NIH, Rocky Mountain Laboratories, Hamilton, MT 59840., Kelsey Johnson M; COVID-19 International Research Team, Medford, MA 02155.; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287., Trovao NS; COVID-19 International Research Team, Medford, MA 02155.; Fogarty International Center, NIH, Bethesda, MD 20892., Clark KB; COVID-19 International Research Team, Medford, MA 02155.; Cures Within Reach, Chicago, IL 60602.; Champions Service, Computational Sciences Support Network, Multi-Tier Assistance, Training, and Computational Help Track, NSF's Advanced Cyberinfrastructure Coordination Ecosystem: Services and Support, Carnegie-Mellon University, Pittsburgh, PA 15213., Zaksas V; COVID-19 International Research Team, Medford, MA 02155.; Center for Translational Data Science, University of Chicago, Chicago, IL 60615.; Clever Research Lab, Springfield, IL 62704., Meller R; COVID-19 International Research Team, Medford, MA 02155.; Morehouse School of Medicine, Atlanta, GA 30310., Grabham P; COVID-19 International Research Team, Medford, MA 02155.; Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 19103., Schisler JC; COVID-19 International Research Team, Medford, MA 02155.; University of North Carolina, Chapel Hill, NC 27599., Moraes-Vieira PM; COVID-19 International Research Team, Medford, MA 02155.; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil 13083-862., Pollett S; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University, Bethesda, MD 20814.; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD 20817., Mason CE; COVID-19 International Research Team, Medford, MA 02155.; Weill Cornell Medicine, New York, NY 10065.; New York Genome Center, New York, NY 10013., Syrkin Wurtele E; COVID-19 International Research Team, Medford, MA 02155.; Center for Metabolic Biology, Bioinformatics and Computational Biology, and Genetics Development, and Cell Biology, Iowa State University, Ames, IA 50011.; Center for Bioinformatics and Computational Biology Iowa State University, Ames, IA 50011.; Center for Genetics Development, and Cell Biology Iowa State University, Ames, IA 50011., Taylor D; COVID-19 International Research Team, Medford, MA 02155.; The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Department of Biomedical and Health, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104., Schwartz RE; COVID-19 International Research Team, Medford, MA 02155.; Weill Cornell Medicine, New York, NY 10065., Beheshti A; COVID-19 International Research Team, Medford, MA 02155.; Stanley Center for Psychiatric Research, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142.; Blue Marble Space Institute of Science, Seattle, WA 98104.; McGowan Institute for Regenerative Medicine and Center for Space Biomedicine, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15219., Wallace DC; COVID-19 International Research Team, Medford, MA 02155.; The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Division of Human Genetics, Department of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104., Baylin SB; COVID-19 International Research Team, Medford, MA 02155.; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287.; Van Andel Institute, Grand Rapids, MI 49503.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Dec 03; Vol. 121 (49), pp. e2401968121. Date of Electronic Publication: 2024 Nov 27.

Type III Interferon-Mediated Signaling Is Critical for Controlling Live Attenuated Yellow Fever Virus Infection In Vivo .

Autor: Douam F; Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA., Soto Albrecht YE; Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA., Hrebikova G; Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA., Sadimin E; Department of Pathology, Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA., Davidson C; Department of Pathology, Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA., Kotenko SV; Department of Microbiology, Biochemistry and Molecular Genetics, Center for Immunity and Inflammation, Cancer Institute of New Jersey, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA., Ploss A; Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA aploss@princeton.edu.

Publikováno v: MBio [mBio] 2017 Aug 15; Vol. 8 (4). Date of Electronic Publication: 2017 Aug 15.