Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Sotiris C. Masmanidis"'
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 3 (2022)
Converging evidence suggests the brain encodes time in dynamic patterns of neural activity, including neural sequences, ramping activity, and complex dynamics. Most temporal tasks, however, require more than just encoding time, and can have distinct
Externí odkaz:
https://doaj.org/article/8f38555882cc432689f1776e9cc8a1c8
Autor:
Justin L. Shobe, Elissa J. Donzis, Kwang Lee, Samiksha Chopra, Sotiris C. Masmanidis, Carlos Cepeda, Michael S. Levine
Publikováno v:
Neurobiology of Disease, Vol 157, Iss , Pp 105447- (2021)
Huntington's disease (HD) is a progressive, fatal neurodegenerative disorder characterized by motor, cognitive, and psychiatric disturbances. There is no known cure for HD, but its progressive nature allows for early therapeutic intervention. Current
Externí odkaz:
https://doaj.org/article/23018235b2024f95bbe738d7aa2c872f
Autor:
Kwang Lee, Konstantin I. Bakhurin, Leslie D. Claar, Sandra M. Holley, Natalie C. Chong, Carlos Cepeda, Michael S. Levine, Sotiris C. Masmanidis
Publikováno v:
Cell Reports, Vol 29, Iss 8, Pp 2438-2449.e4 (2019)
Summary: The cortex and thalamus send excitatory projections to the striatum, but little is known about how these inputs, either individually or collectively, regulate striatal dynamics during behavior. The lateral striatum receives overlapping input
Externí odkaz:
https://doaj.org/article/6687792c86704d40893e8394ebcf8d59
Autor:
Maria T. Lazaro, Jiannis Taxidis, Tristan Shuman, Iris Bachmutsky, Taruna Ikrar, Rommel Santos, G. Mark Marcello, Apoorva Mylavarapu, Swasty Chandra, Allison Foreman, Rachna Goli, Duy Tran, Nikhil Sharma, Michelle Azhdam, Hongmei Dong, Katrina Y. Choe, Olga Peñagarikano, Sotiris C. Masmanidis, Bence Rácz, Xiangmin Xu, Daniel H. Geschwind, Peyman Golshani
Publikováno v:
Cell Reports, Vol 27, Iss 9, Pp 2567-2578.e6 (2019)
Summary: Loss-of-function mutations in CNTNAP2 cause a syndromic form of autism spectrum disorder in humans and produce social deficits, repetitive behaviors, and seizures in mice. However, the functional effects of these mutations at cellular and ci
Externí odkaz:
https://doaj.org/article/b37d3121d9364eef8ae2bad55467c648
Publikováno v:
eLife, Vol 12 (2024)
The striatum serves an important role in motor control, and neurons in this area encode the body’s initiation, cessation, and speed of locomotion. However, it remains unclear whether the same neurons also encode the step-by-step rhythmic motor patt
Externí odkaz:
https://doaj.org/article/5022af0683fb4f81a886f8d71278c767
Autor:
Sung Won Hur, Karen Safaryan, Long Yang, Hugh T Blair, Sotiris C Masmanidis, Paul J Mathews, Daniel Aharoni, Peyman Golshani
Publikováno v:
eLife, Vol 12 (2024)
The cerebellum has been implicated in the regulation of social behavior. Its influence is thought to arise from communication, via the thalamus, to forebrain regions integral in the expression of social interactions, including the anterior cingulate
Externí odkaz:
https://doaj.org/article/13aeb5862e504ba791a9bb403ebcd5ea
Autor:
Sung Won Hur, Karen Safaryan, Long Yang, Hugh T Blair, Sotiris C Masmanidis, Paul J Mathews, Daniel Aharoni, Peyman Golshani
The cerebellum has been implicated in the regulation of social behavior. Its influence is thought to arise from communication, via the thalamus, to forebrain regions integral in the expression of social interactions, including the anterior cingulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9ebb1b363c244ad4ea5776ef32d9b59
https://doi.org/10.1101/2023.04.05.535750
https://doi.org/10.1101/2023.04.05.535750
Autor:
Merel Dagher, Katie A. Perrotta, Sara A. Erwin, Ayaka Hachisuka, Rahul Iyer, Sotiris C. Masmanidis, Hongyan Yang, Anne M. Andrews
Publikováno v:
ACS Chem Neurosci
Targeting neurons with light-driven opsins is widely used to investigate cell-specific responses. We transfected midbrain dopamine neurons with the excitatory opsin Chrimson. Extracellular basal and stimulated neurotransmitter levels in the dorsal st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c78991a5ebea62248ee777bcc7c5f99
https://doi.org/10.1021/acschemneuro.1c00715
https://doi.org/10.1021/acschemneuro.1c00715
Autor:
Charltien Long, Kwang Lee, Long Yang, Theresia Dafalias, Alexander K. Wu, Sotiris C. Masmanidis
While the contribution of dopaminergic (DA) neurons to associative learning is firmly established, their importance for influencing imminent behavior on short (subsecond) timescales is less clear. Mechanistically, it is thought that DA neurons drive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7787c0937117c53b87388fdaadf0121
https://doi.org/10.1101/2022.09.16.508310
https://doi.org/10.1101/2022.09.16.508310
Autor:
Anna Tokarska, Stefanos Stagkourakis, Sotiris C. Masmanidis, Ming Zhou, Gilad Silberberg, Kwang Lee, Christian Broberger, Matthijs C. Dorst
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Striatal activity is dynamically modulated by acetylcholine and dopamine, both of which are essential for basal ganglia function. Synchronized pauses in the activity of striatal cholinergic interneurons (ChINs) are correlated with elevated activity o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd26bd700a9ad4c0c06e3abc07f2a396
http://link.springer.com/article/10.1038/s41467-020-18882-y
http://link.springer.com/article/10.1038/s41467-020-18882-y