Towards Elucidating Carnosic Acid Biosynthesis in Lamiaceae: Functional Characterization of the Three First Steps of the Pathway in Salvia fruticosa and Rosmarinus officinalis.

Autor: Dragana Božić, Dimitra Papaefthimiou, Kathleen Brückner, Ric C H de Vos, Constantinos A Tsoleridis, Dimitra Katsarou, Antigoni Papanikolaou, Irini Pateraki, Fani M Chatzopoulou, Eleni Dimitriadou, Stefanos Kostas, David Manzano, Ulschan Scheler, Albert Ferrer, Alain Tissier, Antonios M Makris, Sotirios C Kampranis, Angelos K Kanellis

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0124106 (2015)

Carnosic acid (CA) is a phenolic diterpene with anti-tumour, anti-diabetic, antibacterial and neuroprotective properties that is produced by a number of species from several genera of the Lamiaceae family, including Salvia fruticosa (Cretan sage) and

Externí odkaz: https://doaj.org/article/8c92833a77fa45808cd128278fead321

Developing a yeast cell factory for the production of terpenoids

Autor: Sotirios C Kampranis, Antonios Michael Makris

Publikováno v: Computational and Structural Biotechnology Journal, Vol 3, Iss 4, p e201210006 (2012)

Technological developments over the past century have made microbes the work-horses of large scale industrial production processes. Current efforts focus on the metabolic engineering of microbial strains to produce high levels of desirable end-produc

Externí odkaz: https://doaj.org/article/b7bd00c375cb42a88987066084f89fca

A gene cluster in Ginkgo biloba encodes unique multifunctional cytochrome P450s that initiate ginkgolide biosynthesis

Autor: Victor Forman, Dan Luo, Fernando Geu-Flores, René Lemcke, David R. Nelson, Sotirios C. Kampranis, Dan Staerk, Birger Lindberg Møller, Irini Pateraki

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

Although ginkgo terpenoids have been studied extensively for their pharmaceutical properties, knowledge on their biosynthesis remains limited. Here, the authors identify five multifunctional cytochrome P450s that catalyze the generation of the tert-b

Externí odkaz: https://doaj.org/article/625d23f8b7ba4ad3881949143a0e2ccc

Secondary Metabolites with Anti-Inflammatory Activity from Laurencia majuscula Collected in the Red Sea

Autor: Mohamed A. Tammam, Maria G. Daskalaki, Nikolaos Tsoureas, Ourania Kolliniati, Aldoushy Mahdy, Sotirios C. Kampranis, Christos Tsatsanis, Vassilios Roussis, Efstathia Ioannou

Publikováno v: Marine Drugs, Vol 21, Iss 2, p 79 (2023)

The chemical investigation of the organic extract of the red alga Laurencia majuscula collected from Hurghada reef in the Red Sea resulted in the isolation of five C15 acetogenins, including four tricyclic ones of the maneonene type (1–4) and a 5-m

Externí odkaz: https://doaj.org/article/def34c1d77404888b45dc695d9b87b34

Metabolic engineering of cucurbitacins in Cucurbita pepo hairy roots

Autor: Aldo Almeida, Lemeng Dong, Theis H. Thorsen, Morten H. Raadam, Bekzod Khakimov, Natalia Carreno-Quintero, Sotirios C. Kampranis, Søren Bak

Publikováno v: Almeida, A, Dong, L, Thorsen, T H, Raadam, M H, Khakimov, B, Carreno-Quintero, N, Kampranis, S C & Bak, S 2022, ' Metabolic engineering of cucurbitacins in Cucurbita pepo hairy roots ', Frontiers in Plant Science, vol. 13, 1021907 . https://doi.org/10.3389/fpls.2022.1021907
Frontiers in Plant Science, 13:1021907. Frontiers Media S.A.

In this paper we show that metabolic engineering in Cucurbita pepo hairy roots can be used to both effectively increase and modify cucurbitacins. Cucurbitacins are highly-oxygenated triterpenoids originally described in the Cucurbitaceae family, but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dcef1ea35b0a2c95842c3a0f37567dc
https://doi.org/10.3389/fpls.2022.1021907