Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Sotiria Tavoulari"'
Autor:
Vasiliki Mavridou, Martin S. King, Sotiria Tavoulari, Jonathan J. Ruprecht, Shane M. Palmer, Edmund R. S. Kunji
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The mitochondrial ADP/ATP carrier transports adenine nucleotides. Here, authors identify the residues involved in substrate binding. One set forms the central substrate binding site and two asparagine/arginine pairs help to guide the substrates durin
Externí odkaz:
https://doaj.org/article/a4a0d085f23f4c14a0e50b7bdf2ecf0d
Autor:
Sotiria Tavoulari, Tom J.J. Schirris, Vasiliki Mavridou, Chancievan Thangaratnarajah, Martin S. King, Daniel T.D. Jones, Shujing Ding, Ian M. Fearnley, Edmund R.S. Kunji
Publikováno v:
Molecular Metabolism, Vol 60, Iss , Pp 101469- (2022)
Objective: The mitochondrial pyruvate carrier (MPC) has emerged as a promising drug target for metabolic disorders, including non-alcoholic steatohepatitis and diabetes, metabolically dependent cancers and neurodegenerative diseases. A range of struc
Externí odkaz:
https://doaj.org/article/810e7cfd9e4b433a99f25e042e2d0e52
Autor:
Martin S. King, Sotiria Tavoulari, Vasiliki Mavridou, Alannah C. King, John Mifsud, Edmund R. S. Kunji
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 23, p 8971 (2020)
Cryptosporidiumparvum is a clinically important eukaryotic parasite that causes the disease cryptosporidiosis, which manifests with gastroenteritis-like symptoms. The protist has mitosomes, which are organelles of mitochondrial origin that have only
Externí odkaz:
https://doaj.org/article/a0a16d23e2044cf1a465d5bf2ec4cb58
Autor:
Calum Wilson, Sotiria Tavoulari
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
Pyruvate is oxidized to acetyl‐CoA by pyruvate dehydrogenase which is localized in the mitochondrial matrix. The mitochondrial pyruvate carrier (MPC) is composed of SLC54 family members (MPC1 and MPC2) [1, 5], which form functional hetero-dimers [9
Publikováno v:
Trends in endocrinology and metabolism: TEM. 33(8)
Citrin deficiency is a pan-ethnic and highly prevalent mitochondrial disease with three different stages: neonatal intrahepatic cholestasis (NICCD), a relatively mild adaptation stage, and type II citrullinemia in adulthood (CTLN2). The cause is the
Autor:
Sotiria Tavoulari, Vasiliki Mavridou, Chancievan Thangaratnarajah, Edmund R.S. Kunji, Jean-Claude Martinou, Michael E. Harbour
Publikováno v:
The EMBO Journal
The mitochondrial pyruvate carrier (MPC) is critical for cellular homeostasis, as it is required in central metabolism for transporting pyruvate from the cytosol into the mitochondrial matrix. MPC has been implicated in many diseases and is being inv
Autor:
Sotiria Tavoulari, Gary Rudnick, Lucy R. Forrest, Yuan-Wei Zhang, Antoniya A. Aleksandrova, Steffen Sinning
Publikováno v:
Proceedings of the National Academy of Sciences. 115
The coupled transport of ions and substrates allows transporters to accumulate substrates using the energy in transmembrane ion gradients and electrical potentials. During transport, conformational changes that switch accessibility of substrate and i
Autor:
Valerie L. Ashton, Roger Springett, Homa Majd, Mikhail Kibalchenko, Paul G. Crichton, Antoniya A. Aleksandrova, Elizabeth Cerson, Edmund R.S. Kunji, Martin S. King, Jonathan J. Ruprecht, Sotiria Tavoulari
Publikováno v:
Biochimica et biophysica acta. 1863(12)
Autor:
Sotiria Tavoulari, Edmund R.S. Kunji, Roger Springett, Valerie L. Ashton, Paul G. Crichton, Martin S. King, Homa Majd, Mikhail Kibalchenko, Elizabeth Cerson, Antoniya A. Aleksandrova, Jonathan J. Ruprecht
Publikováno v:
Biochimica et biophysica acta. 1863(10)
The mitochondrial ADP/ATP carrier imports ADP from the cytosol and exports ATP from the mitochondrial matrix, which are key transport steps for oxidative phosphorylation in eukaryotic organisms. The transport protein belongs to the mitochondrial carr
Autor:
Gary Rudnick, Lucy R. Forrest, Elizabeth Rhoades, Edwin Rosado, Sotiria Tavoulari, Silvia Ravera, Anu Nagarajan, Yuan-Wei Zhang, David C. DeWitt, Eleonora Margheritis
Publikováno v:
The Journal of biological chemistry. 291(3)
In LeuT, a prokaryotic homolog of neurotransmitter transporters, Na(+) stabilizes outward-open conformational states. We examined how each of the two LeuT Na(+) binding sites contributes to Na(+)-dependent closure of the cytoplasmic pathway using bio