Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Sotiria Bexis"'
Autor:
Sotiria Bexis, James R. Docherty
Publikováno v:
British Journal of Pharmacology. 158:259-266
Background and purpose: We have investigated the ability of the β3-adrenoceptor antagonist 1-(2-ethylphenoxy)-3-[[(1S)-1,2,3,4,-tetrahydro-1-naphthalenyl]amino]-(2S)-2-propanol hydrochloride (SR59230A) to affect the hyperthermia produced by methylen
Publikováno v:
European Journal of Pharmacology. 590:322-326
We have investigated the actions of the postacyclin receptor antagonist BAY 73-1449 on shunt vessel development and shunt flow in the portal vein ligated portal hypertensive Wistar rat in vivo. BAY 73-1449 (0.1-1 mg/kg), given intravenously, did not
Publikováno v:
European Journal of Pharmacology. 587:216-223
We have investigated the role of nitric oxide (NO) in relaxations to beta-adrenoceptor agonists in mesenteric artery from wild-type (WT) and NO synthase-3 knockout (NOS-3-KO) mice. Isoprenaline, formoterol and BRL 37344 ((R(),R())-(+/-)-4-[2-[(2-(3-c
Publikováno v:
Autonomic and Autacoid Pharmacology. 28:81-85
1 It has been demonstrated that nerve-evoked contractions of the rat vas deferens involve alpha(1D)-adrenoceptors. Definitive evidence for a similar alpha(1D)-adrenoceptor-mediated response in mouse vas deferens has been more difficult to obtain. In
Autor:
Sotiria Bexis, James R. Docherty
Publikováno v:
British Journal of Pharmacology. 153:591-597
Background and purpose: We have investigated the ability of α1-adrenoceptor antagonists to affect the hyperthermia produced by methylenedioxy methamphetamine (MDMA) in conscious mice. Experimental approach: Mice were implanted with temperature probe
Autor:
Sotiria Bexis, James R. Docherty
Publikováno v:
British Journal of Pharmacology. 147:926-934
The effects of injection of 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyamphetamine (MDA) and N-ethyl-3,4-methylenedioxyamphetamine (MDEA) (all 20 mg kg(-1)) on blood pressure, heart rate, core body temperature and locomotor activity
Publikováno v:
Autonomic and Autacoid Pharmacology. 25:135-141
1 We have investigated the actions of the alpha(1D)-adrenoceptor selective antagonist BMY 7378 in comparison with yohimbine at alpha(1)- and alpha(2)-adrenoceptors. 2 In rat aorta (alpha(1D)-adrenoceptor), BMY 7378 (pA(2) of 8.67) was about 100 times
Autor:
Sotiria Bexis, James R. Docherty
Publikováno v:
British Journal of Pharmacology. 146:1-6
3,4-Methylenedioxymetamphetamine (MDMA) produces complex effects on body temperature, including hypo- and hyperthermic components that vary with ambient temperature and strain of rat. We have previously reported that MDMA is an α2-adrenoceptor agoni
Publikováno v:
British Journal of Pharmacology. 143:745-752
We have previously demonstrated that contractions of rat vas deferens to exogenous noradrenaline involve predominantly α1A-adrenoceptors, but that contractions to endogenous noradrenaline involve predominantly α1D-adrenoceptors. In this study, we h
Publikováno v:
European Journal of Pharmacology. 499:325-333
The effects of pre-hepatic portal hypertension were examined on the responsiveness of aorta and mesenteric artery from wild-type, inducible nitric oxide synthase knockout (iNOS-KO) and endothelial nitric oxide synthase knockout (eNOS-KO) mice. Mice w