Výsledky vyhledávání - "Sotheavy Chhum"

Akademický článek

104 Development and characterization of human chimeric antigen receptor monocytes (CAR-Mono), a novel cell therapy platform

Autor: Daniel Blumenthal, Michael Klichinsky, Linara Gabitova, Michael Lynch, Sascha Abramson, Brett Menchel, Patricia Reyes-Uribe, Andrew Best, Sotheavy Chhum, Maggie Schmierer

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

Externí odkaz: https://doaj.org/article/9b553f4911624700be40983d67c86582

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104 Development and characterization of human chimeric antigen receptor monocytes (CAR-Mono), a novel cell therapy platform

Autor: Maggie Schmierer, Andrew Best, Brett Menchel, Linara Gabitova, Michael Klichinsky, Patricia Reyes-Uribe, Sascha Abramson, Sotheavy Chhum, Daniel Blumenthal, Michael Lynch

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

BackgroundEngineered cell therapies have demonstrated significant clinical activity against hematologic malignancies, but solid tumors remain an intractable challenge. We have previously developed a human chimeric antigen receptor macrophage (CAR-M)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f2507077c22caaa7b76b0dd199a2185
https://doaj.org/article/9b553f4911624700be40983d67c86582

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Abstract 3242: CT-0508 is an anti-HER2 chimeric antigen receptor (CAR) macrophage with targeted anti-tumor activity that promotes a pro-inflammatory solid tumor microenvironment

Autor: Sotheavy Chhum, Michael Klichinsky, Nicholas E. Petty, Xueqing Lu, Konrad Gabrusiewicz, Xinhe Shan, Maggie Schmierer, Olga Shestova, Andrew Best, Feng Shen, Yumi Ohtani, Nicholas R. Anderson, Martha Zeeman, Saar Gill

Publikováno v: Cancer Research. 80:3242-3242

Despite recent advances in T cell immunotherapy for the treatment of human cancer, metastatic solid tumors remain an intractable challenge. Macrophages are often the most abundant immune cell in the tumor microenvironment (TME) where, as immunosuppre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23b8f37c71fcfaab27909a32bf2647f3
https://doi.org/10.1158/1538-7445.am2020-3242

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The Affinity of Protein C for the Thrombin·Thrombomodulin Complex Is Determined in a Primary Way by Active Site-dependent Interactions

Autor: Sriram Krishnaswamy, Genmin Lu, Sotheavy Chhum

Publikováno v: Journal of Biological Chemistry. 280:15471-15478

The interaction of thrombin (IIa) with thrombomodulin (TM) is essential for the efficient activation of protein C (PC). Interactions between PC and extended surfaces, likely contributed by TM within the IIa.TM complex, have been proposed to play a ke

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a0929b8efee1263a116dd13b96584ba
https://doi.org/10.1074/jbc.m500881200

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