Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Sotaro Kikuchi"'
Autor:
Hitoki Nanaura, Honoka Kawamukai, Ayano Fujiwara, Takeru Uehara, Yuichiro Aiba, Mari Nakanishi, Tomo Shiota, Masaki Hibino, Pattama Wiriyasermkul, Sotaro Kikuchi, Riko Nagata, Masaya Matsubayashi, Yoichi Shinkai, Tatsuya Niwa, Taro Mannen, Naritaka Morikawa, Naohiko Iguchi, Takao Kiriyama, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Takashi Oda, Noriyuki Kodera, Sachiko Toma-Fukai, Mamoru Sato, Hideki Taguchi, Shushi Nagamori, Osami Shoji, Koichiro Ishimori, Hiroyoshi Matsumura, Kazuma Sugie, Tomohide Saio, Takuya Yoshizawa, Eiichiro Mori
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nuclear import receptors (NIRs) regulate self-association of RNA-binding proteins as phase modifiers, while C9orf72-derived arginine-rich polydipeptides lead to aberrant phase transitions. Here the authors show in molecular basis how arginine-rich po
Externí odkaz:
https://doaj.org/article/84769c6bce8f47bf9553e2e7438eb8a6
Autor:
Tomo Shiota, Riko Nagata, Sotaro Kikuchi, Hitoki Nanaura, Masaya Matsubayashi, Mari Nakanishi, Shinko Kobashigawa, Noriyoshi Isozumi, Takao Kiriyama, Kazuaki Nagayama, Kazuma Sugie, Yoshito Yamashiro, Eiichiro Mori
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Proline:arginine (PR) poly-dipeptides from the GGGGCC repeat expansion in C9orf72 have cytotoxicity and bind intermediate filaments (IFs). However, it remains unknown how PR poly-dipeptides affect cytoskeletal organization and focal adhesion (FA) for
Externí odkaz:
https://doaj.org/article/127c5e93e5f34ec286e28118e7e7fe8a
Autor:
Naoki Iwasa, Takeshi K. Matsui, Naohiko Iguchi, Kaoru Kinugawa, Naritaka Morikawa, Yoshihiko M. Sakaguchi, Tomo Shiota, Shinko Kobashigawa, Mari Nakanishi, Masaya Matsubayashi, Riko Nagata, Sotaro Kikuchi, Tatsuhide Tanaka, Nobuyuki Eura, Takao Kiriyama, Tesseki Izumi, Kozue Saito, Hiroshi Kataoka, Yuichi Saito, Wataru Kimura, Akio Wanaka, Yuhei Nishimura, Eiichiro Mori, Kazuma Sugie
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Ischemic stroke is one of the most common neurological diseases. However, the impact of ischemic stroke on human cerebral tissue remains largely unknown due to a lack of ischemic human brain samples. In this study, we applied cerebral organoids deriv
Externí odkaz:
https://doaj.org/article/29a9de7003d54004a5e46ac6ae706bbf
Autor:
Eunhee Choi, Sotaro Kikuchi, Haishan Gao, Karolina Brodzik, Ibrahim Nassour, Adam Yopp, Amit G. Singal, Hao Zhu, Hongtao Yu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
The mechanisms promoting insulin resistance at the receptor level are poorly understood. Here, Choi et al. show that mitotic proteins and the SHP2-MAPK pathway regulate receptor endocytosis and insulin signaling feedback, identifying a potential role
Externí odkaz:
https://doaj.org/article/819277c64772481c8648587394125c81
Autor:
Takeshi K. Matsui, Eiichiro Mori, Genro Kashino, Atsuhisa Kajihara, Yoshihiko M. Sakaguchi, Tadaaki Kirita, Sotaro Kikuchi, Soichiro S. Ito, Masatoshi Hasegawa, Shinko Kobashigawa, Fumika Kitayoshi, Hitoki Nanaura, Kazuma Sugie, Mari Nakanishi, Masaya Matsubayashi, Shigehiro Tamaki, Akihisa Takahashi, Yosuke Nakagawa
Publikováno v:
J Biol Chem
The anticancer agent 5-fluorouracil (5-FU) is cytotoxic and often used to treat various cancers. 5-FU is thought to inhibit the enzyme thymidylate synthase, which plays a role in nucleotide synthesis and has been found to induce single- and double-st
Autor:
Naohiko Iguchi, Takeru Uehara, Tatsuya Niwa, Sachiko Toma-Fukai, Sotaro Kikuchi, Taro Mannen, Ayano Fujiwara, Masaaki Sugiyama, Mari Nakanishi, Mamoru Sato, Tomohide Saio, Eiichiro Mori, Hiroyoshi Matsumura, Hideki Taguchi, Kazuma Sugie, Masaya Matsubayashi, Yoichi Shinkai, Takao Kiriyama, Riko Nagata, Takashi Oda, Tomo Shiota, Yuichiro Aiba, Naritaka Morikawa, Rintaro Inoue, Masaki Hibino, Koichiro Ishimori, Hitoki Nanaura, Takuya Yoshizawa, Noriyuki Kodera, Pattama Wiriyasermkul, Osami Shoji, Shushi Nagamori, Ken Morishima, Honoka Kawamukai
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nuclear import receptors (NIRs) not only transport RNA-binding proteins (RBPs) but also modify phase transitions of RBPs by recognizing nuclear localization signals (NLSs). Toxic arginine-rich poly-dipeptides from C9orf72 interact with NIRs and cause
Autor:
Ibrahim Nassour, Karolina Brodzik, Hao Zhu, Sotaro Kikuchi, Eunhee Choi, Haishan Gao, Adam C. Yopp, Hongtao Yu, Amit G. Singal
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications
Insulin controls glucose homeostasis and cell growth through bifurcated signaling pathways. Dysregulation of insulin signaling is linked to diabetes and cancer. The spindle checkpoint controls the fidelity of chromosome segregation during mitosis. He
Autor:
Takahiko Nakagawa, Sotaro Kikuchi, Kazuma Sugie, Hitoki Nanaura, Eiichiro Mori, Shin Takasawa, Minoru Takasato, Yoshiki Sahara, Shushi Nagamori, Takeshi K. Matsui, Michihisa Umetani, Masaya Matsubayashi, Kazuhiko Tsuruya, Masahiro Eriguchi, Linh Bui, Arvand Asghari, Mari Nakanishi, Shinko Kobashigawa, Genro Kashino, Riko Nagata, Yoshihiko M. Sakaguchi, Masatoshi Hasegawa
Publikováno v:
The FASEB Journal
The excretion and reabsorption of uric acid both to and from urine are tightly regulated by uric acid transporters. Metabolic syndrome conditions, such as obesity, hypercholesterolemia, and insulin resistance, are believed to regulate the expression
Autor:
Yoshito Yamashiro, Masaya Matsubayashi, Tomo Shiota, Sotaro Kikuchi, Mari Nakanishi, Eiichiro Mori, Kazuma Sugie, Hitoki Nanaura, Shinko Kobashigawa, Riko Nagata, Kazuaki Nagayama
Amyotrophic lateral sclerosis (ALS) is an irreversible neurodegenerative disease caused by the degeneration of motor neurons, and cytoskeletal instability is considered to be involved in neurodegeneration. A hexanucleotide repeat expansion of the C9o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0a7abbcbfafe0980548289d1623c4a6
https://doi.org/10.1101/2020.10.14.338566
https://doi.org/10.1101/2020.10.14.338566
Autor:
Naoki, Iwasa, Takeshi K, Matsui, Naohiko, Iguchi, Kaoru, Kinugawa, Naritaka, Morikawa, Yoshihiko M, Sakaguchi, Tomo, Shiota, Shinko, Kobashigawa, Mari, Nakanishi, Masaya, Matsubayashi, Riko, Nagata, Sotaro, Kikuchi, Tatsuhide, Tanaka, Nobuyuki, Eura, Takao, Kiriyama, Tesseki, Izumi, Kozue, Saito, Hiroshi, Kataoka, Yuichi, Saito, Wataru, Kimura, Akio, Wanaka, Yuhei, Nishimura, Eiichiro, Mori, Kazuma, Sugie
Publikováno v:
Frontiers in Cellular Neuroscience
Ischemic stroke is one of the most common neurological diseases. However, the impact of ischemic stroke on human cerebral tissue remains largely unknown due to a lack of ischemic human brain samples. In this study, we applied cerebral organoids deriv