Role of Kindlin 2 in prostate cancer.

Autor: Bialkowska K; Department of Cardiovascular Biology and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44139, USA., El Khalki L; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA.; Case Comprehensive Cancer Center, Cleveland, OH, USA., Rana PS; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA.; Case Comprehensive Cancer Center, Cleveland, OH, USA., Wang W; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA.; Case Comprehensive Cancer Center, Cleveland, OH, USA., Lindner DJ; Case Comprehensive Cancer Center, Cleveland, OH, USA.; Translational Hematology and Oncology Research, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, USA., Parker Y; Case Comprehensive Cancer Center, Cleveland, OH, USA., Languino LR; Department of Pharmacology, Physiology and Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA., Altieri DC; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA., Pluskota E; Department of Cardiovascular Biology and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44139, USA., Sossey-Alaoui K; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA. kxs586@case.edu.; Case Comprehensive Cancer Center, Cleveland, OH, USA. kxs586@case.edu.; Division of Cancer Biology, MetroHealth Medical Center, Rammelkamp Center for Research, R457, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA. kxs586@case.edu., Plow EF; Department of Cardiovascular Biology and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44139, USA. plowe@ccf.org.

Publikováno v: Scientific reports [Sci Rep] 2024 Aug 27; Vol. 14 (1), pp. 19809. Date of Electronic Publication: 2024 Aug 27.

Expression of the αVβ3 integrin affects prostate cancer sEV cargo and density and promotes sEV pro-tumorigenic activity in vivo through a GPI-anchored receptor, NgR2.

Autor: Verrillo CE; Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Quaglia F; Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Shields CD; Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Lin S; Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Kossenkov AV; Bioinformatics Shared Resource, Center for Systems and Computational Biology, The Wistar Institute, Philadelphia, Pennsylvania, USA., Tang HY; Proteomics and Metabolomics Shared Resource, The Wistar Institute, Philadelphia, Pennsylvania, USA., Speicher D; Proteomics and Metabolomics Shared Resource, The Wistar Institute, Philadelphia, Pennsylvania, USA., Naranjo NM; Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Testa A; Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Kelly WK; Department of Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Liu Q; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania, USA., Leiby B; Division of Biostatistics, Department of Pharmacology, Physiology, and Cancer Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Musante L; Extracellular Vesicle Core, PennVet, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Sossey-Alaoui K; Department of Medicine, Case Western Reserve University, School of Medicine MetroHealth Medical Center Rammelkamp Center for Research, Cleveland, Ohio, USA., Dogra N; Department of Pathology and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Chen TY; Department of Pathology and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Altieri DC; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania, USA., Languino LR; Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Publikováno v: Journal of extracellular vesicles [J Extracell Vesicles] 2024 Aug; Vol. 13 (8), pp. e12482.

Time-resolved live-cell spectroscopy reveals EphA2 multimeric assembly.

Autor: Shi X; Division of Cancer Biology, Department of Medicine, MetroHealth Medical Center, Cleveland, OH 44109, USA.; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA., Lingerak R; Division of Cancer Biology, Department of Medicine, MetroHealth Medical Center, Cleveland, OH 44109, USA.; Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA., Herting CJ; Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, GA 30322, USA., Ge Y; Department of Molecular Biology, Massachusetts General Hospital and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Kim S; Division of Cancer Biology, Department of Medicine, MetroHealth Medical Center, Cleveland, OH 44109, USA.; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA., Toth P; Department of Chemistry, University of Akron, Akron, OH 44325, USA., Wang W; Division of Cancer Biology, Department of Medicine, MetroHealth Medical Center, Cleveland, OH 44109, USA., Brown BP; Department of Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA., Meiler J; Department of Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA., Sossey-Alaoui K; Division of Cancer Biology, Department of Medicine, MetroHealth Medical Center, Cleveland, OH 44109, USA., Buck M; Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.; Case Comprehensive Cancer Center, Cleveland, OH 44106, USA., Himanen J; Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Hambardzumyan D; Departments Oncological Sciences and Neurosurgery, Tisch Cancer Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029, USA., Nikolov DB; Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Smith AW; Department of Chemistry, University of Akron, Akron, OH 44325, USA., Wang B; Division of Cancer Biology, Department of Medicine, MetroHealth Medical Center, Cleveland, OH 44109, USA.; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.; Case Comprehensive Cancer Center, Cleveland, OH 44106, USA.; Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2023 Dec; Vol. 382 (6674), pp. 1042-1050. Date of Electronic Publication: 2023 Nov 16.

Parkin ubiquitination of Kindlin-2 enables mitochondria-associated metastasis suppression.

Autor: Yeon M; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania, USA., Bertolini I; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania, USA., Agarwal E; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania, USA., Ghosh JC; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania, USA., Tang HY; Proteomics and Metabolomics Shared Resource, The Wistar Institute, Philadelphia, Pennsylvania, USA; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania, USA., Speicher DW; Proteomics and Metabolomics Shared Resource, The Wistar Institute, Philadelphia, Pennsylvania, USA; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania, USA., Keeney F; Imaging Shared Resource, The Wistar Institute, Philadelphia, Pennsylvania, USA., Sossey-Alaoui K; Department of Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA., Pluskota E; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Bialkowska K; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Plow EF; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Languino LR; Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Skordalakes E; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania, USA., Caino MC; Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado, USA., Altieri DC; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania, USA. Electronic address: daltieri@wistar.org.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2023 Jun; Vol. 299 (6), pp. 104774. Date of Electronic Publication: 2023 May 02.

WAVE3 phosphorylation regulates the interplay between PI3K, TGF-β, and EGF signaling pathways in breast cancer.

Autor: Wang W; Department of Medicine, Rammelkamp Center for Research, Cleveland, OH, USA., Kansakar U; Department of Medicine, Rammelkamp Center for Research, Cleveland, OH, USA., Markovic V; Department of Medicine, Rammelkamp Center for Research, Cleveland, OH, USA., Wang B; Department of Medicine, Rammelkamp Center for Research, Cleveland, OH, USA.; Case Western Reserve University School of Medicine, Cleveland, OH, USA.; Case Comprehensive Cancer Center, Cleveland, OH, USA., Sossey-Alaoui K; Department of Medicine, Rammelkamp Center for Research, Cleveland, OH, USA. Kxs586@case.edu.; Case Western Reserve University School of Medicine, Cleveland, OH, USA. Kxs586@case.edu.; Case Comprehensive Cancer Center, Cleveland, OH, USA. Kxs586@case.edu.

Publikováno v: Oncogenesis [Oncogenesis] 2020 Oct 05; Vol. 9 (10), pp. 87. Date of Electronic Publication: 2020 Oct 05.