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pro vyhledávání: '"Sosic A"'
Many real-world systems exhibit temporal, dynamic behaviors, which are captured as time series of complex agent interactions. To perform temporal reasoning, current methods primarily encode temporal dynamics through simple sequence-based models. Howe
Externí odkaz:
http://arxiv.org/abs/2401.03134
Autor:
Emanuele Fornasier, Simone Fabbian, Haidi Shehi, Janine Enderle, Barbara Gatto, Daniele Volpin, Barbara Biondi, Massimo Bellanda, Gabriele Giachin, Alice Sosic, Roberto Battistutta
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract Many enzymes work as homodimers with two distant catalytic sites, but the reason for this choice is often not clear. For the main protease Mpro of SARS-CoV-2, dimerization is essential for function and plays a regulatory role during the coro
Externí odkaz:
https://doaj.org/article/1acb2ae723db4d6792e6ca45800ef122
Autor:
Wu, Tailin, Tjandrasuwita, Megan, Wu, Zhengxuan, Yang, Xuelin, Liu, Kevin, Sosič, Rok, Leskovec, Jure
Humans have the remarkable ability to recognize and acquire novel visual concepts in a zero-shot manner. Given a high-level, symbolic description of a novel concept in terms of previously learned visual concepts and their relations, humans can recogn
Externí odkaz:
http://arxiv.org/abs/2206.15049
Autor:
Wu, Tailin, Wang, Qinchen, Zhang, Yinan, Ying, Rex, Cao, Kaidi, Sosič, Rok, Jalali, Ridwan, Hamam, Hassan, Maucec, Marko, Leskovec, Jure
Subsurface simulations use computational models to predict the flow of fluids (e.g., oil, water, gas) through porous media. These simulations are pivotal in industrial applications such as petroleum production, where fast and accurate models are need
Externí odkaz:
http://arxiv.org/abs/2206.07680
Autor:
Jing Xu, John E. Coughlin, Malgorzata Szyjka, Serene Jabary, Sonal Saluja, Zoran Sosic, Yunqiu Chen, Chong-Feng Xu
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTAggregates are recognized as one of the most critical product-related impurities in monoclonal antibody (mAb)-based therapeutics due to their negative impact on the stability and safety of the drugs. So far, investigational efforts have prima
Externí odkaz:
https://doaj.org/article/8a4dd72d29084788975e90ab944ead49
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
IntroductionIndividuals diagnosed with depression frequently experience self-criticism, leading to considerable psychological distress. Despite the availability of cognitive-behavioral treatments, a notable proportion of patients indicate that they s
Externí odkaz:
https://doaj.org/article/5438fec4ebf444efa7e2d7787a2b84f9
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
IntroductionAlcohol use disorder (AUD) is a severe clinical disorder, which has been associated with 5.3% of death worldwide. Although several treatments have been developed to improve AUD symptomatology, treatment effects were moderate, with a certa
Externí odkaz:
https://doaj.org/article/c4527a531eb047978b09494e68b0e254
Autor:
Ajdžanović, Vladimir, Šošić-Jurjević, Branka, Živanović, Jasmina, Miler, Marko, Stanković, Sanja, Ranin, Jovan, Filipović, Branko
Publikováno v:
In Annals of Anatomy October 2024 256
Autor:
Herlah, Barbara, Goričan, Tjaša, Benedik, Nika Strašek, Grdadolnik, Simona Golič, Sosič, Izidor, Perdih, Andrej
Publikováno v:
In Computational and Structural Biotechnology Journal December 2024 23:2995-3018
Autor:
Khoury, L. El, Jing, Z., Cuzzolin, A., Deplano, A., Loco, D., Sattarov, B., Hédin, F., Wendeborn, S., Ho, C., Ahdab, D. El, Inizan, T. Jaffrelot, Sturlese, M., Sosic, A., Volpiana, M., Lugato, A., Barone, M., Gatto, B., Macchia, M. Ludovica, Bellanda, M., Battistutta, R., Salata, C., Kondratov, I., Iminov, R., Khairulin, A., Mykhalonok, Y., Pochepko, A., Chashka-Ratushnyi, V., Kos, I., Moro, S., Montes, M., Ren, P., Ponder, J. W., Lagardère, L., Piquemal, J. -P., Sabbadin, D.
Publikováno v:
Chem. Sci., 2022,13, 3674-3687
We report a fast-track computationally-driven discovery of new SARS-CoV2 Main Protease (M$^{pro}$) inhibitors whose potency range from mM for initial non-covalent ligands to sub-$\mu$M for the final covalent compound (IC50=830 +/- 50 nM). The project
Externí odkaz:
http://arxiv.org/abs/2110.05427