No Association Between Polygenic Risk Scores for Cancer and Development of Radiation Therapy Toxicity

Autor: Barnett, Gillian C. ^*, Kerns, Sarah L., Dorling, Leila, Fachal, Laura, Aguado-Barrera, Miguel E., Martínez-Calvo, Laura, Jandu, Harkeran K., Welsh, Ceilidh, Tyrer, Jonathan, Coles, Charlotte E. ^*, Haviland, Joanne S., Parker, Christopher, Gómez-Caamaño, Antonio, Calvo-Crespo, Patricia, Sosa-Fajardo, Paloma, Burnet, Neil G., Summersgill, Holly, Webb, Adam, De Ruysscher, Dirk, Seibold, Petra, Chang-Claude, Jenny, Talbot, Christopher J., Rattay, Tim, Parliament, Matthew, De Ruyck, Kim, Rosenstein, Barry S., Pharoah, Paul D.P., Dunning, Alison M., Vega, Ana, West, Catharine M.L.

Publikováno v: In International Journal of Radiation Oncology, Biology, Physics 1 November 2022 114(3):494-501

Use of angiotensin converting enzyme inhibitors is associated with reduced risk of late bladder toxicity following radiotherapy for prostate cancer

Autor: Azria, David, Briers, Erik, Chang-Claude, Jenny, Choudhury, Ananya, Dunning, Alison, Elliott, Rebecca M, Gutiérrez-Enríquez, Sara, Rancati, Tiziana, Rattay, Tim, Rosenstein, Barry S., De Ruysscher, Dirk, Seibold, Petra, Sperk, Elena, Paul Symonds, R, Stobart, Hilary, Talbot, Christopher J., Vega, Ana, Veldeman, Liv, Ward, Tim, Webb, Adam, West, Catharine M., Kerns, Sarah L., Amidon Morlang, Ashley, Lee, Sharon M., Peterson, Derick R., Marples, Brian, Zhang, Hong, Bylund, Kevin, Rosenzweig, Doug, Hall, William, De Ruyck, Kim, Stock, Richard G., Gómez-Caamaño, Antonio, Sosa-Fajardo, Paloma, Taboada-Valladares, Begoña, Aguado-Barrera, Miguel E., Parker, Chris, Fonteyne, Valérie, Bultijnck, Renée, Symonds, R. Paul, Johnson, Kerstie, Lambrecht, Maarten, de Ruysscher, Dirk, Vanneste, Ben, Elliott, Rebecca M., Herskind, Carsten, Veldwijk, Marlon R., Avuzzi, Barbara, Valdagni, Riccardo, Farcy Jacquet, Marie-Pierre, West, Catharine, Janelsins, Michelle, Chen, Yuhchyau, Messing, Edward, Morrow, Gary

Publikováno v: In Radiotherapy and Oncology March 2022 168:75-82

REQUITE: A prospective multicentre cohort study of patients undergoing radiotherapy for breast, lung or prostate cancer

Autor: Lievens, Yolande, van Eijkeren, Marc, Vandecasteele, Katrien, Elhamin, Elhaseen, Ost, Piet, Fonteyne, Valérie, Swimberghe, Martijn, Deseyne, Pieter, De Neve, Wilfried, Duprez, Fréderic, Mareel, Marcus, Monten, Chris, Van Greveling, Annick, Vercauteren, Tom, Paelinck, Leen, Defraene, Gilles, Aerts, Rita, Arredouani, Soumia, Lambrecht, Maarten, Vanneste, Ben, Draghici, Roxana, Giordano, Frank, Herskind, Carsten, Veldwijk, Marlon, Helmbold, Irmgard, Giesche, Ulrich, Stegmaier, Petra, Weiß, Christian, Blaschke, Thomas, Neu, Burkhard, Lozza, Laura, Avuzzi, Barbara, Morlino, Sara, Sangalli, Claudia, Franceschini, Marzia, Rodriguez-Lage, Belina, Fernández-Tajes, Juan, Fuentes-Rios, Olivia, Domínguez-Rios, Isabel, Fajardo-Paneque, Irene, Sosa-Fajardo, Paloma, Torrado-Moya, Laura, Ramos-Albiac, Mónica, Giraldo, Alexandra, Altabas, Manolo, Piqué-Leiva, Bibiana, García-Relancio, David, Seoane-Ramallo, Alejandro, Lavers, Samuel, Wright, Simon, Dobbelaere, Hannah, Appleton, Donna, Kaushik, Monika, Kenny, Frances, Khout, Hazem, Krupa, Jaroslaw, Lambert, Kelly V., Pilgrim, Simon, Shokuhi, Sheila, Valassiadou, Kalliope, Aznar-Garcia, Luis, Boiangui, Ion, Kancherla, Kiran, Kent, Christopher, Sampson, Kufre, Osman, Ahmed, Sridhar, Thiagarajan, Vasanthan, Subramaniam, Faivre-Finn, Corinne, Harrop, Victoria, Keni, Manjusha, Foweraker, Karen, Pascoe, Abigail, Esler, Claire, Stock, Richard, Green, Sheryl, Golchin, Ava, Li, William, Seibold, Petra, Webb, Adam, Aguado-Barrera, Miguel E., Azria, David, Bourgier, Celine, Brengues, Muriel, Briers, Erik, Bultijnck, Renée, Calvo-Crespo, Patricia, Carballo, Ana, Choudhury, Ananya, Cicchetti, Alessandro, Claßen, Johannes, Delmastro, Elena, Dunning, Alison M., Elliott, Rebecca M., Fachal, Laura, Farcy-Jacquet, Marie-Pierre, Gabriele, Pietro, Garibaldi, Elisabetta, Gómez-Caamaño, Antonio, Gutiérrez-Enríquez, Sara, Higginson, Daniel S., Johnson, Kerstie, Lobato-Busto, Ramón, Mollà, Meritxell, Müller, Anusha, Payne, Debbie, Peleteiro, Paula, Post, Giselle, Rancati, Tiziana, Rattay, Tim, Reyes, Victoria, Rosenstein, Barry S., De Ruysscher, Dirk, De Santis, Maria Carmen, Schäfer, Jörg, Schnabel, Thomas, Sperk, Elena, Symonds, R. Paul, Stobart, Hilary, Taboada-Valladares, Begoña, Talbot, Christopher J., Valdagni, Riccardo, Vega, Ana, Veldeman, Liv, Ward, Tim, Weißenberger, Christian, West, Catharine M.L., Chang-Claude, Jenny

Publikováno v: In Radiotherapy and Oncology September 2019 138:59-67

Treatment time and circadian genotype interact to influence radiotherapy side-effects. A prospective European validation study using the REQUITE cohort

Autor: Webb, Adam J, Harper, Emily, Rattay, Tim, Aguado-Barrera, Miguel E, Azria, David, Bourgier, Celine, Brengues, Muriel, Briers, Erik, Bultijnck, Renée, Chang-Claude, Jenny, Choudhury, Ananya, Cicchetti, Alessandro, De Ruysscher, Dirk, De Santis, Maria Carmen, Dunning, Alison M, Elliott, Rebecca M, Fachal, Laura, Gómez-Caamaño, Antonio, Gutiérrez-Enríquez, Sara, Johnson, Kerstie, Lobato-Busto, Ramón, Kerns, Sarah L, Post, Giselle, Rancati, Tiziana, Reyes, Victoria, Rosenstein, Barry S, Seibold, Petra, Seoane, Alejandro, Sosa-Fajardo, Paloma, Sperk, Elena, Taboada-Valladares, Begoña, Valdagni, Riccardo, Vega, Ana, Veldeman, Liv, Ward, Tim, West, Catharine M, Symonds, R Paul, Talbot, Christopher J, REQUITE Consortium

BACKGROUND: Circadian rhythm impacts broad biological processes, including response to cancer treatment. Evidence conflicts on whether treatment time affects risk of radiotherapy side-effects, likely because of differing time analyses and target tiss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93a0f24d623521867aa7de75f94c8b95

No Association Between Polygenic Risk Scores for Cancer and Development of Radiation Therapy Toxicity

Autor: Barnett, Gillian C, Kerns, Sarah L, Dorling, Leila, Fachal, Laura, Aguado-Barrera, Miguel E, Martínez-Calvo, Laura, Jandu, Harkeran K, Welsh, Ceilidh, Tyrer, Jonathan, Coles, Charlotte E, Haviland, Joanne S, Parker, Christopher, Gómez-Caamaño, Antonio, Calvo-Crespo, Patricia, Sosa-Fajardo, Paloma, Burnet, Neil G, Summersgill, Holly, Webb, Adam, De Ruysscher, Dirk, Seibold, Petra, Chang-Claude, Jenny, Talbot, Christopher J, Rattay, Tim, Parliament, Matthew, De Ruyck, Kim, Rosenstein, Barry S, Pharoah, Paul DP, Dunning, Alison M, Vega, Ana, West, Catharine ML, RGC and REQUITE Consortia

PURPOSE: Our aim was to test whether updated polygenic risk scores (PRS) for susceptibility to cancer affect risk of radiation therapy toxicity. METHODS AND MATERIALS: Analyses included 9,717 patients with breast (n=3,078), prostate (n=5,748) or lung

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514de806b4fa03b19a1734ffbb690c50