Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Sorin Armeanu"'
Autor:
Christopher Schroeder, Sergios Gatidis, Olga Kelemen, Leon Schütz, Irina Bonzheim, Francesc Muyas, Peter Martus, Jakob Admard, Sorin Armeanu-Ebinger, Brigitte Gückel, Thomas Küstner, Claus Garbe, Lukas Flatz, Christina Pfannenberg, Stephan Ossowski, Andrea Forschner
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Immune checkpoint inhibitors (ICI) have significantly improved overall survival in melanoma patients. However, 60% experience severe adverse events and early response markers are lacking. Circulating tumour DNA (ctDNA) is a promising biomark
Externí odkaz:
https://doaj.org/article/e37c3f00da754d3194cbd8a961ea54c2
Autor:
Michael Menzel, Stephan Ossowski, Sebastian Kral, Patrick Metzger, Peter Horak, Ralf Marienfeld, Melanie Boerries, Steffen Wolter, Markus Ball, Olaf Neumann, Sorin Armeanu-Ebinger, Christopher Schroeder, Uta Matysiak, Hannah Goldschmid, Vincent Schipperges, Axel Fürstberger, Michael Allgäuer, Timo Eberhardt, Jakob Niewöhner, Andreas Blaumeiser, Carolin Ploeger, Tobias Bernd Haack, Timothy Kwang Yong Tay, Olga Kelemen, Thomas Pauli, Martina Kirchner, Klaus Kluck, Alexander Ott, Marcus Renner, Jakob Admard, Axel Gschwind, Silke Lassmann, Hans Kestler, Falko Fend, Anna Lena Illert, Martin Werner, Peter Möller, Thomas Theodor Werner Seufferlein, Nisar Malek, Peter Schirmacher, Stefan Fröhling, Daniel Kazdal, Jan Budczies, Albrecht Stenzinger
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-11 (2023)
Abstract A growing number of druggable targets and national initiatives for precision oncology necessitate broad genomic profiling for many cancer patients. Whole exome sequencing (WES) offers unbiased analysis of the entire coding sequence, segmenta
Externí odkaz:
https://doaj.org/article/c80cfb96a9be48f6bbb8329e92275143
Autor:
Henning Zelba, Christina Kyzirakos, Simone Kayser, Borong Shao, Annekathrin Reinhardt, Natalia Pieper, Armin Rabsteyn, Dennis Döcker, Sorin Armeanu-Ebinger, Matthias Kloor, Dirk Hadaschik, Martin Schulze, Florian Battke, Alexander Golf, Saskia Biskup
Publikováno v:
Vaccines, Vol 12, Iss 4, p 397 (2024)
Ovarian cancer is one of the most common cancers among women and the most lethal malignancy of all gynecological cancers. Surgery is promising in the early stages; however, most patients are first diagnosed in the advanced stages, where treatment opt
Externí odkaz:
https://doaj.org/article/71d99f3c84404e52ae0b8a7bc9721f6d
Autor:
Alexandra Liebmann, Jakob Admard, Sorin Armeanu-Ebinger, Hannah Wild, Michael Abele, Axel Gschwind, Olga Seibel-Kelemen, Christian Seitz, Irina Bonzheim, Olaf Riess, German Demidov, Marc Sturm, Malou Schadeck, Michaela Pogoda, Ewa Bien, Malgorzata Krawczyk, Eva Jüttner, Thomas Mentzel, Maja Cesen, Elke Pfaff, Michal Kunc, Stephan Forchhammer, Andrea Forschner, Ulrike Leiter-Stöppke, Thomas K. Eigentler, Dominik T. Schneider, Christopher Schroeder, Stephan Ossowski, Ines B. Brecht
Publikováno v:
EBioMedicine, Vol 96, Iss , Pp 104797- (2023)
Summary: Background: Genomic characterisation has led to an improved understanding of adult melanoma. However, the aetiology of melanoma in children is still unclear and identifying the correct diagnosis and therapeutic strategies remains challenging
Externí odkaz:
https://doaj.org/article/127dec53e6d3434d85e40f46cbf6798e
Autor:
Michael Bitzer, Stephan Spahn, Sepideh Babaei, Marius Horger, Stephan Singer, Klaus Schulze-Osthoff, Pavlos Missios, Sergios Gatidis, Dominik Nann, Sven Mattern, Veit Scheble, Konstantin Nikolaou, Sorin Armeanu-Ebinger, Martin Schulze, Christopher Schroeder, Saskia Biskup, Janina Beha, Manfred Claassen, Kristina Ruhm, Antti Poso, Nisar P. Malek
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-7 (2021)
Abstract Intrahepatic cholangiocarcinoma (iCCA) has emerged as a promising candidate for precision medicine, especially in the case of activating FGFR2 gene fusions. In addition to fusions, a considerable fraction of iCCA patients reveals FGFR2 mutat
Externí odkaz:
https://doaj.org/article/e53c22a8e93b49a59453c658ede63a6d
Detection of mobile elements insertions for routine clinical diagnostics in targeted sequencing data
Autor:
German Demidov, Joohyun Park, Sorin Armeanu‐Ebinger, Cristiana Roggia, Ulrike Faust, Isabell Cordts, Maria Blandfort, Tobias B. Haack, Christopher Schroeder, Stephan Ossowski
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 9, Iss 12, Pp n/a-n/a (2021)
Abstract Background Targeted sequencing approaches such as gene panel or exome sequencing have become standard of care for the diagnosis of rare and common genetic disease. The detection and interpretation of point mutations, small insertions and del
Externí odkaz:
https://doaj.org/article/a80b9a73d0b24247a4afc747f08528e9
Autor:
Andrea Forschner, Tobias Sinnberg, Gabi Mroz, Christopher Schroeder, Christian Philipp Reinert, Sergios Gatidis, Michael Bitzer, Thomas Eigentler, Claus Garbe, Heike Niessner, Martin Röcken, Cristiana Roggia, Sorin Armeanu-Ebinger, Olaf Riess, Sven Mattern, Dominik Nann, Irina Bonzheim
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
There are only limited treatment options for metastatic NRAS mutant melanoma patients with resistance to immune checkpoint inhibitors. Besides activation of the mitogen-activated protein (MAP) kinase pathway, they often have additional disturbances i
Externí odkaz:
https://doaj.org/article/6b5fa4e28cf6446eb01795863edeb2ee
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 2, Pp 4190-4208 (2015)
Pediatric hepatoblastoma (HB) is commonly treated by neoadjuvant chemotherapy and surgical tumor resection according to international multicenter trial protocols. Complete tumor resection is essential and survival rates up to 95% have now been achiev
Externí odkaz:
https://doaj.org/article/ab25f05b8d1740318e777d0ca4adcf2b
Autor:
Martina Zimmermann, Sorin Armeanu-Ebinger, Sascha Bossow, Johanna Lampe, Irina Smirnow, Andrea Schenk, Sebastian Lange, Thomas S Weiss, Wolfgang Neubert, Ulrich M Lauer, Michael Bitzer
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90508 (2014)
Multiple types of oncolytic viruses are currently under investigation in clinical trials. To optimize therapeutic outcomes it is believed that the plethora of different tumor types will require a diversity of different virus types. Sendai virus (SeV)
Externí odkaz:
https://doaj.org/article/dbf8a5eb3e6e4abe89c1df655bd5ca3a
Autor:
Sorin Armeanu-Ebinger, Julia Wenz, Guido Seitz, Ivo Leuschner, Rupert Handgretinger, Ulrike A Mau-Holzmann, Michael Bonin, Bence Sipos, Jörg Fuchs, Steven W Warmann
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e38223 (2012)
Current treatment of paediatric hepatocellular carcinoma (HCC) is often inefficient due to advanced disease at diagnosis and resistance to common drugs. The aim of this study was to generate a cell line derived from a paediatric HCC in order to expan
Externí odkaz:
https://doaj.org/article/ad2e010ed1d748ef807466abed93dadf