Novel genes and sex differences in COVID-19 severity

Autor: Cruz, R, Diz-de Almeida, S, de Heredia, ML, Quintela, I, Ceballos, FC, Lorenzo-Salazar, GM, Gonzalez-Montelongo, R, Gago-Dominguez, M, Porras, MS, Castano, JAT, Nevado, J, Aguado, JM, Aguilar, C, Aguilera-Albesa, S, Almadana, V, Almoguera, B, Alvarez, N, Andreu-Bernabeu, A, Arana-Arri, E, Arango, C, Arranz, MJ, Artiga, MJ, Baptista-Rosas, RC, Barreda-Sanchez, M, Belhassen-Garcia, M, Bezerra, JF, Bezerra, MAC, Boix-Palop, L, Brion, M, Brugada, R, Bustos, M, Calderon, EJ, Carbonell, C, Castano, L, Castelao, JE, Conde-Vicente, R, Cordero-Lorenzana, ML, Cortes-Sanchez, JL, Corton, M, Darnaude, MT, De Martino-Rodriguez, A, del Campo-Perez, V, de Bustamante, AD, Dominguez-Garrido, E, Luchessi, AD, Eiros, R, Sanabria, GME, Carmen Farinas, M, Fernandez-Robelo, U, Fernandez-Rodriguez, A, Fernandez-Villa, T, Gil-Fournier, B, Gomez-Arrue, J, Alvarez, BG, de Quiros, FGB, Gonzalez-Penas, J, Gutierrez-Bautista, JF, Herrero, MJ, Herrero-Gonzalez, A, Jimenez-Sousa, MA, Lattig, MC, Borja, AL, Lopez-Rodriguez, R, Mancebo, E, Martin-Lopez, C, Martin, V, Martinez-Nieto, O, Martinez-Lopez, I, Martinez-Resendez, MF, Martinez-Perez, A, Mazzeu, JF, Macias, EM, Minguez, P, Cuerda, VM, Silbiger, VN, Oliveira, SF, Ortega-Paino, E, Parellada, M, Paz-Artal, E, Santos, NPC, Perez-Matute, P, Perez, P, Perez-Tomas, ME, Perucho, T, Pinsach-Abuin, ML, Pompa-Mera, EN, Porras-Hurtado, GL, Pujol, A, Leon, SR, Resino, S, Fernandes, MR, Rodriguez-Ruiz, E, Rodriguez-Artalejo, F, Rodriguez-Garcia, JA, Cabello, FR, Ruiz-Hornillos, J, Ryan, P, Soria, JM, Souto, JC, Tamayo, E, Tamayo-Velasco, A, Taracido-Fernandez, JC, Teper, A, Torres-Tobar, L, Urioste, M, Valencia-Ramos, J, Yanez, Z, Zarate, R, Nakanishi, T, Pigazzini, S, Degenhardt, F, Butler-Laporte, G, Maya-Miles, D, Bujanda, L, Bouysran, Y, Palom, A, Ellinghaus, D, Martinez-Bueno, M, Rolker, S, Amitrano, S, Roade, L, Fava, F, Spinner, CD, Prati, D, Bernardo, D, Garcia, F, Darcis, G, Fernandez-Cadenas, I, Holter, JC, Banales, JM, Frithiof, R, Duga, S, Asselta, R, Pereira, AC, Romero-Gomez, M, Nafria-Jimenez, B, Hov, JR, Migeotte, I, Renieri, A, Planas, AM, Ludwig, KU, Buti, M, Rahmouni, S, Alarcon-Riquelme, ME, Schulte, EC, Franke, A, Karlsen, TH, Valenti, L, Zeberg, H, Richards, B, Ganna, A, Boada, M, de Rojas, I, Ruiz, A, Sanchez-Juan, P, Real, LM, Guillen-Navarro, E, Ayuso, C, Gonzalez-Neira, A, Riancho, JA, Rojas-Martinez, A, Flores, C, Lapunzina, P, Carracedo, A

Publikováno v: HUMAN MOLECULAR GENETICS
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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Here, we describe the results of a genome-wide study conducted in 11939 coronavirus disease 2019 (COVID-19) positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::b0847a182b644cdd2f442804a39d8a51
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=12313

A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology

Autor: de Vries, PS, Sabater-Lleal, M, Huffman, JE, Marten, J, Song, C, Pankratz, N, Bartz, TM, de Haan, HG, Delgado, GE, Eicher, JD, Martinez-Perez, A, Ward-Caviness, CK, Brody, JA, Chen, MH, de Maat, MPM, Franberg, M, Gill, D, Kleber, ME, Rivadeneira, F, Soria, JM, Tang, WH, Tofler, GH, Uitterlinden, AG, Vlieg, AV, Seshadri, S, Boerwinkle, E, Davies, NM, Giese, AK, Ikram, MK, Kittner, SJ, McKnight, B, Psaty, BM, Reiner, AP, Sargurupremraj, M, Taylor, KD, Fornage, M, Hamsten, A, Marz, W, Rosendaal, FR, Souto, JC, Dehghan, A, Johnson, AD, Morrison, AC, O'Donnell, CJ, Smith, NL, INVENT Consortium, MEGASTROKE Consortium Intl

Publikováno v: BLOOD
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
de Vries, P S, Sabater-Lleal, M, Huffman, J E, Marten, J, Song, C, Pankratz, N, Bartz, T M, de Haan, H G, Delgado, G E, Eicher, J D, Martinez-Perez, A, Ward-Caviness, C K, Brody, J A, Chen, M-H, de Maat, M P M, Frånberg, M, Gill, D, Kleber, M E, Rivadeneira, F, Soria, J M, Tang, W, Tofler, G H, Uitterlinden, A G, van Hylckama Vlieg, A, Seshadri, S, Boerwinkle, E, Davies, N M, Giese, A-K, Ikram, M K, Kittner, S J, McKnight, B, Psaty, B M, Reiner, A P, Sargurupremraj, M, Taylor, K D, Fornage, M, Hamsten, A, März, W, Rosendaal, F R, Souto, J C, Dehghan, A, Johnson, A D, Morrison, A C, O'Donnell, C J & Smith, N L 2019, ' A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology ', Blood, vol. 133, no. 9, pp. 967-977 . https://doi.org/10.1182/blood-2018-05-849240
Blood, 133(9), 967-977. American Society of Hematology
Blood, 133(9), 967-977

Factor VII (FVII) is an important component of the coagulation cascade. Few genetic loci regulating FVII activity and/or levels have been discovered to date. We conducted a meta-analysis of nine genome-wide association studies of plasma FVII levels (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ee0c9817b2b3e415332a0a2d71f217
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2980

High incidence of FXI deficiency in a Spanish town caused by 11 different mutations and the first duplication of F11: Results from the Yecla study

Autor: Esteban, J, de la Morena-Barrio, ME, Salloum-Asfar, S, Padilla, J, Minano, A, Roldan, V, Soria, JM, Vidal, F, Corral, J, Vicente, V

Publikováno v: HAEMOPHILIA
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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IntroductionFactor XI (FXI) deficiency is a rare disorder with molecular heterogeneity in Caucasians but relatively frequent and molecularly homogeneous in certain populations. AimTo characterize FXI deficiency in a Spanish town of 60000 inhabitants.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::101c92d0ba2978a8fe642476025939c3
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6022

Genetic determinants of cardiometabolic risk factors in rural families in Brazil

Autor: Pena, GG, Martinez-Perez, A, Dutra, MS, Gazzinelli, A, Correa-Oliveira, R, Soria, JM, Velasquez-Melendez, G

Publikováno v: AMERICAN JOURNAL OF HUMAN BIOLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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ObjectivesThe purpose of this study was to estimate the heritability of genetic and environmental correlations between cardiometabolic risk factors in extended pedigrees. MethodsThe Jequitinhonha Community Family Study Cohort (JCFSC) consists of indi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::c6093851c89b347ef211a324901ad221
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=7054

Neurotoxic effects of ochratoxin A on the subventricular zone of adult mouse brain

Autor: Paradells S, Rocamonde B, Llinares C, Herranz-Perez V, Jimenez M, Garcia-Verdugo JM, Zipancic I, Soria JM, Garcia-Esparza MA

Publikováno v: JOURNAL OF APPLIED TOXICOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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Ochratoxin A (OTA), a mycotoxin that was discovered as a secondary metabolite of the fungal species Aspergillus and Penicillium, is a common contaminant in food and animal feed. This mycotoxin has been described as teratogenic, carcinogenic, genotoxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::95cab6386222256a765f61ecad88eb2f
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=9759