Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Soren R. Paludan"'
Autor:
Anji Wei, Di Yin, Zimeng Zhai, Sikai Ling, Huangying Le, Lijia Tian, Jianjiang Xu, Soren R Paludan, Yujia Cai, Jiaxu Hong
In vivo CRISPR gene therapy holds large clinical potential, but the safety and efficacy remain largely unknown. Here, we injected a single dose of HSV-1-targeting CRISPR formulation in the cornea of three patients with severe refractory herpes stroma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d9eba2ab541a0cd988d97e43f2e1817
https://doi.org/10.1101/2023.02.21.23285822
https://doi.org/10.1101/2023.02.21.23285822
Autor:
Isara Alee, Papasara Chantawichitwong, Asada Leelahavanichkul, Søren R. Paludan, Trairak Pisitkun, Prapaporn Pisitkun
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract The absence of stimulator of interferon genes (STING) in 129.B6.Fcgr2b-deficient mice rescue lupus phenotypes. The administration of a STING inhibitor (ISD017) into the young 129.B6.Fcgr2b-deficient mice prevents lupus nephritis development.
Externí odkaz:
https://doaj.org/article/3510b9f412524a89b9490c74e10aa2e6
Autor:
Jonas Govaerts, Elise Van Breedam, Sarah De Beuckeleer, Charlotte Goethals, Claudio Peter D’Incal, Julia Di Stefano, Siebe Van Calster, Tamariche Buyle-Huybrecht, Marlies Boeren, Hans De Reu, Søren R. Paludan, Marc Thiry, Marielle Lebrun, Catherine Sadzot-Delvaux, Helena Motaln, Boris Rogelj, Johan Van Weyenbergh, Winnok H. De Vos, Wim Vanden Berghe, Benson Ogunjimi, Peter Delputte, Peter Ponsaerts
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Varicella-zoster virus (VZV) encephalitis and meningitis are potential central nervous system (CNS) complications following primary VZV infection or reactivation. With Type-I interferon (IFN) signalling being an important first line cellular defence
Externí odkaz:
https://doaj.org/article/a886acf2bf824812b60e03bc4e9326a1
Autor:
Bao-cun Zhang, Marlene F. Laursen, Lili Hu, Hossein Hazrati, Ryo Narita, Lea S. Jensen, Aida S. Hansen, Jinrong Huang, Yan Zhang, Xiangning Ding, Maimaitili Muyesier, Emil Nilsson, Agnieszka Banasik, Christina Zeiler, Trine H. Mogensen, Anders Etzerodt, Ralf Agger, Mogens Johannsen, Emil Kofod-Olsen, Søren R. Paludan, Martin R. Jakobsen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The cGAS-STING pathway plays a crucial role in anti-tumoral responses by activating inflammation and reprogramming the tumour microenvironment. Upon activation, STING traffics from the endoplasmic reticulum (ER) to Golgi, allowing signalling
Externí odkaz:
https://doaj.org/article/d5f211afbe2146aea0d8433928886c3f
Autor:
Demi van der Horst, Naziia Kurmasheva, Mikkel H. S. Marqvorsen, Sonia Assil, Anna H. F. Rahimic, Christoph F. Kollmann, Leandro Silva da Costa, Qi Wu, Jian Zhao, Eleonora Cesari, Marie B. Iversen, Fanghui Ren, Trine I. Jensen, Ryo Narita, Vivien R. Schack, Bao-cun Zhang, Rasmus O. Bak, Claudio Sette, Robert A. Fenton, Jacob G. Mikkelsen, Søren R. Paludan, David Olagnier
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract DNA is a danger signal sensed by cGAS to engage signaling through STING to activate innate immune functions. The best-studied downstream responses to STING activation include expression of type I interferon and inflammatory genes, but STING
Externí odkaz:
https://doaj.org/article/0db80e2a99374afa9c136a61eb6b74e2
Autor:
Justin V. Joseph, Huiqiang Cai, Brian Hansen, Soren R. Paludan, Mikkel Vendelbo, Martin K. Thomsen
Publikováno v:
Cancer Research. 82:3512-3512
Intrinsic malignant brain tumors, such as glioblastoma (GBM) are frequently resistant to immunotherapy with few hyper-mutated glioblastomas showing response. Here we have applied a long-term treatment with STING agonist and PD-1 inhibitors alone and
Autor:
Soren R Paludan, Trine H. Mogensen
Publikováno v:
Paludan, S R & Mogensen, T H 2021, ' Constitutive and latent immune mechanisms exert ‘silent’ control of virus infections in the central nervous system ', Current Opinion in Immunology, vol. 72, pp. 158-166 . https://doi.org/10.1016/j.coi.2021.05.004
Viral infections in the central nervous system (CNS) can lead to severe disease manifestations often mediated by a combination of viral cytopathic effects and immunopathology. Moreover, neuronal tissue and brain activities are highly sensitive to exc
Autor:
Isabelle K. Vila, Hanane Chamma, Alizée Steer, Mathilde Saccas, Clara Taffoni, Evgenia Turtoi, Line S. Reinert, Saqib Hussain, Johanna Marines, Lei Jin, Xavier Bonnefont, Mathieu Hubert, Olivier Schwartz, Soren R. Paludan, Gaetan Van Simaeys, Gilles Doumont, Bijan Sobhian, Dimitrios Vlachakis, Andrei Turtoi, Nadine Laguette
Publikováno v:
Cell Metabolism
Cell Metabolism, 2022, 34 (1), pp.125-139.e8. ⟨10.1016/j.cmet.2021.12.007⟩
Vila, I K, Chamma, H, Steer, A, Saccas, M, Taffoni, C, Turtoi, E, Reinert, L S, Hussain, S, Marines, J, Jin, L, Bonnefont, X, Hubert, M, Schwartz, O, Paludan, S R, Van Simaeys, G, Doumont, G, Sobhian, B, Vlachakis, D, Turtoi, A & Laguette, N 2022, ' STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses ', Cell Metabolism, vol. 34, no. 1, pp. 125-139.e8 . https://doi.org/10.1016/j.cmet.2021.12.007
Cell Metabolism, Elsevier, 2022, 34 (1), pp.125-139.e8. ⟨10.1016/j.cmet.2021.12.007⟩
Cell Metabolism, 2022, 34 (1), pp.125-139.e8. ⟨10.1016/j.cmet.2021.12.007⟩
Vila, I K, Chamma, H, Steer, A, Saccas, M, Taffoni, C, Turtoi, E, Reinert, L S, Hussain, S, Marines, J, Jin, L, Bonnefont, X, Hubert, M, Schwartz, O, Paludan, S R, Van Simaeys, G, Doumont, G, Sobhian, B, Vlachakis, D, Turtoi, A & Laguette, N 2022, ' STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses ', Cell Metabolism, vol. 34, no. 1, pp. 125-139.e8 . https://doi.org/10.1016/j.cmet.2021.12.007
Cell Metabolism, Elsevier, 2022, 34 (1), pp.125-139.e8. ⟨10.1016/j.cmet.2021.12.007⟩
Summary Concerted alteration of immune and metabolic homeostasis underlies several inflammation-related pathologies, ranging from metabolic syndrome to infectious diseases. Here, we explored the coordination of nucleic acid-dependent inflammatory res
Autor:
Björn Becker, Felix Wottawa, Mohamed Bakr, Eric Koncina, Lisa Mayr, Julia Kugler, Guang Yang, Samuel J. Windross, Laura Neises, Neha Mishra, Danielle Harris, Florian Tran, Lina Welz, Julian Schwärzler, Zoltán Bánki, Stephanie T. Stengel, Go Ito, Christina Krötz, Olivia I. Coleman, Christian Jaeger, Dirk Haller, Søren R. Paludan, Richard Blumberg, Arthur Kaser, Luka Cicin-Sain, Stefan Schreiber, Timon E. Adolph, Elisabeth Letellier, Philip Rosenstiel, Johannes Meiser, Konrad Aden
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109173- (2024)
Summary: Inflammatory bowel diseases are characterized by the chronic relapsing inflammation of the gastrointestinal tract. While the molecular causality between endoplasmic reticulum (ER) stress and intestinal inflammation is widely accepted, the me
Externí odkaz:
https://doaj.org/article/b82b754dd2874bbc89024fd998a49788
Autor:
Ensieh Farahani, Line S. Reinert, Ryo Narita, Manutea C. Serrero, Morten Kelder Skouboe, Demi van der Horst, Sonia Assil, Baocun Zhang, Marie B. Iversen, Eugenio Gutierrez, Hossein Hazrati, Mogens Johannsen, David Olagnier, Reiner Kunze, Mark Denham, Trine H. Mogensen, Michael Lappe, Søren R. Paludan
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113792- (2024)
Summary: Pattern recognition receptors (PRRs) induce host defense but can also induce exacerbated inflammatory responses. This raises the question of whether other mechanisms are also involved in early host defense. Using transcriptome analysis of di
Externí odkaz:
https://doaj.org/article/44f664b9af4a437aa62a40c3c3077e62