Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Soren AB"'
Autor:
Colin Hemez, Fabrizio Clarelli, Adam C. Palmer, Christina Bleis, Sören Abel, Leonid Chindelevitch, Theodore Cohen, Pia Abel zur Wiesch
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 4688-4703 (2022)
Antibiotic-resistant pathogens are a major public health threat. A deeper understanding of how an antibiotic’s mechanism of action influences the emergence of resistance would aid in the design of new drugs and help to preserve the effectiveness of
Externí odkaz:
https://doaj.org/article/64f42ecd435d49bab02b90fbb1cf678c
Autor:
Anel Mahmutovic, Aaron Nicholas Gillman, Silje Lauksund, Natasha-Anne Robson Moe, Aime Manzi, Merete Storflor, Pia Abel zur Wiesch, Sören Abel
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 1035-1051 (2021)
Microbial division rates determine the speed of mutation accumulation and thus the emergence of antimicrobial resistance. Microbial death rates are affected by antibiotic action and the immune system. Therefore, measuring these rates has advanced our
Externí odkaz:
https://doaj.org/article/4d975169c28e4ac99a446990b4a3acbb
Publikováno v:
mSystems, Vol 6, Iss 6 (2021)
ABSTRACT During infection, the rates of pathogen replication, death, and migration affect disease progression, dissemination, transmission, and resistance evolution. Here, we follow the population dynamics of Vibrio cholerae in a mouse model by label
Externí odkaz:
https://doaj.org/article/7ac5a0dd437a4c22aa1ae2aabdc7aa05
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 791-804 (2020)
Transposon insertion sequencing methods such as Tn-seq revolutionized microbiology by allowing the identification of genomic loci that are critical for viability in a specific environment on a genome-wide scale. While powerful, transposon insertion s
Externí odkaz:
https://doaj.org/article/f559f71a31294aa987afd93eefc6fece
Autor:
Fabrizio Clarelli, Adam Palmer, Bhupender Singh, Merete Storflor, Silje Lauksund, Ted Cohen, Sören Abel, Pia Abel Zur Wiesch
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 8, p e1008106 (2020)
Antibiotic resistance is rising and we urgently need to gain a better quantitative understanding of how antibiotics act, which in turn would also speed up the development of new antibiotics. Here, we describe a computational model (COMBAT-COmputation
Externí odkaz:
https://doaj.org/article/cedf55b060ce4ede83872a81b49ec7a9
Autor:
Alyson R Warr, Troy P Hubbard, Diana Munera, Carlos J Blondel, Pia Abel Zur Wiesch, Sören Abel, Xiaoxue Wang, Brigid M Davis, Matthew K Waldor
Publikováno v:
PLoS Pathogens, Vol 15, Iss 8, p e1007652 (2019)
Enterohemorrhagic Escherichia coli O157:H7 (EHEC) is an important food-borne pathogen that colonizes the colon. Transposon-insertion sequencing (TIS) was used to identify genes required for EHEC and E. coli K-12 growth in vitro and for EHEC growth in
Externí odkaz:
https://doaj.org/article/fc771d6512744e9a861868904cbe23c8
Publikováno v:
PLoS Pathogens, Vol 11, Iss 6, p e1004823 (2015)
Externí odkaz:
https://doaj.org/article/e78db87cb21e47c68b7bf196d1fc386c
Autor:
Justin R Pritchard, Michael C Chao, Sören Abel, Brigid M Davis, Catherine Baranowski, Yanjia J Zhang, Eric J Rubin, Matthew K Waldor
Publikováno v:
PLoS Genetics, Vol 10, Iss 11, p e1004782 (2014)
Transposon-insertion sequencing (TIS) is a powerful approach for deciphering genetic requirements for bacterial growth in different conditions, as it enables simultaneous genome-wide analysis of the fitness of thousands of mutants. However, current m
Externí odkaz:
https://doaj.org/article/6d11aade0796443b8c585fe1b3afa10e
Publikováno v:
PLoS Pathogens, Vol 10, Iss 6, p e1004225 (2014)
The rise of resistance together with the shortage of new broad-spectrum antibiotics underlines the urgency of optimizing the use of available drugs to minimize disease burden. Theoretical studies suggest that coordinating empirical usage of antibioti
Externí odkaz:
https://doaj.org/article/1ddd3a5ab77142a5a041ecd081ac5013
Autor:
Sören Abel, Tabitha Bucher, Micaël Nicollier, Isabelle Hug, Volkhard Kaever, Pia Abel Zur Wiesch, Urs Jenal
Publikováno v:
PLoS Genetics, Vol 9, Iss 9, p e1003744 (2013)
Many bacteria mediate important life-style decisions by varying levels of the second messenger c-di-GMP. Behavioral transitions result from the coordination of complex cellular processes such as motility, surface adherence or the production of virule
Externí odkaz:
https://doaj.org/article/8898e52480304c4e84b07b9d39e90a34