Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Sorell L, Schwartz"'
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 383:217-226
Modeling and simulation of the central nervous system provides a tool for understanding and predicting the distribution of small molecules throughout the brain tissue and cerebral spinal fluid (CSF), and these efforts often rely on empirical data to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dfbfdeab87b4e04e48242e9b3123f0f
https://doi.org/10.1124/jpet.122.001256
https://doi.org/10.1124/jpet.122.001256
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics
Bridging fundamental approaches to model optimization for pharmacometricians, systems pharmacologists and statisticians is a critical issue. These fields rely primarily on Maximum Likelihood and Extended Least Squares metrics with iterative estimatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2bb2f91afdefb645620d27d93a6123
https://doi.org/10.1007/s10928-019-09629-4
https://doi.org/10.1007/s10928-019-09629-4
Autor:
Margo Peyton, Jaeil Ahn, Xiaoguang Liu, Alan J. Fowler, Michaeline Hebron, Sara Matar, Joy Arellano, Nadia Yusuf, Barbara Wilmarth, Charbel Moussa, Sorell L. Schwartz, Nathan J. Starr, Helen H. Howard, Fernando Pagan, Yasar Torres-Yaghi, Elizabeth E. Mundel, Abigail Lawler
Publikováno v:
Pharmacology Research & Perspectives
Nilotinib is a broad‐based tyrosine kinase inhibitor with the highest affinity to inhibit Abelson (c‐Abl) and discoidin domain receptors (DDR1/2). Preclinical evidence indicates that Nilotinib reduces the level of brain alpha‐synuclein and atte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71eff89df2d80ff2d3ac18c9fbf3a382
https://pubmed.ncbi.nlm.nih.gov/30906562
https://pubmed.ncbi.nlm.nih.gov/30906562
Autor:
Charbel Moussa, Jaeil Ahn, Yasar Torres-Yaghi, Sorell L. Schwartz, Abigail Lawler, Barbara Wilmarth, Ashot Shekonyan, Michaeline Hebron, Ellen Valladez, Helen Howard, Fernando Pagan
Publikováno v:
SSRN Electronic Journal.
Background: Parkinson's disease (PD) involves motor and non-motor symptoms and loss of brain dopamine neurons. Nilotinib is a tyrosine kinase inhibitor that may alter brain dopamine metabolism. Methods: A phase II randomized, double-blind, placebo co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05a65cf5b039c0fde6bbb2adea07774a
https://doi.org/10.2139/ssrn.3397207
https://doi.org/10.2139/ssrn.3397207
Introduction. Synthesis and Properties of PVP. Movement of Large Molecules Across Membranes-General Considerations. Absorption of PVP by Various Routes of Administration. Excretion and Metabolism of PVP. Distribution and Storage of PVP. Storage of PV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43d57fb6f79492c4de11dbf1422ce826
https://doi.org/10.1201/9780203741672
https://doi.org/10.1201/9780203741672
Autor:
Morgan Craig, Nikhil Pillai, Aristeidis Dokoumetzidis, I. Freedman, Robert R. Bies, Sorell L. Schwartz
Publikováno v:
Progress in biophysics and molecular biology. 139
In mathematical pharmacology, models are constructed to confer a robust method for optimizing treatment. The predictive capability of pharmacological models depends heavily on the ability to track the system and to accurately determine parameters wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17145d4bd7abd366ea2d04b5d6f7c629
https://pubmed.ncbi.nlm.nih.gov/29928905
https://pubmed.ncbi.nlm.nih.gov/29928905
Publikováno v:
British Journal of Clinical Pharmacology. 81:804-806
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13cf6b31428fe5ae41915820ae435519
https://doi.org/10.1111/bcp.12896
https://doi.org/10.1111/bcp.12896
Publikováno v:
British journal of clinical pharmacology. 81(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4b2e44cdce9353df7b974b8681b42451
https://pubmed.ncbi.nlm.nih.gov/26845397
https://pubmed.ncbi.nlm.nih.gov/26845397
Autor:
Sorell L. Schwartz
Publikováno v:
Human & Experimental Toxicology. 29:15-19
Toxicity Testing in the 21st Century: A Vision and a Strategy, from the National Research Council Committee on Toxicity Testing and Assessment of Environmental Agents, presents a vision wherein toxicology testing moves from feeding test substances to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c277fa05668aaf5375819670dba9ede
https://doi.org/10.1177/0960327109354657
https://doi.org/10.1177/0960327109354657
Publikováno v:
Clinical Pharmacology & Therapeutics. 83:904-908
The application of mathematical models to reflect the organization and activity of biological systems can be viewed as a continuum of purpose. The far left of the continuum is solely the prediction of biological parameter values, wherein an understan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5691431ed3055d32939cccfe54a5fe85
https://doi.org/10.1038/clpt.2008.53
https://doi.org/10.1038/clpt.2008.53