Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Soreen Cyphers"'
Autor:
Emily F Ruff, Joseph M Muretta, Andrew R Thompson, Eric W Lake, Soreen Cyphers, Steven K Albanese, Sonya M Hanson, Julie M Behr, David D Thomas, John D Chodera, Nicholas M Levinson
Publikováno v:
eLife, Vol 7 (2018)
Many eukaryotic protein kinases are activated by phosphorylation on a specific conserved residue in the regulatory activation loop, a post-translational modification thought to stabilize the active DFG-In state of the catalytic domain. Here we use a
Externí odkaz:
https://doaj.org/article/f6eb943b1d3d40128485f13e5dbe282f
Publikováno v:
Nature Chemical Biology. 13:402-408
The catalytic activity of many protein kinases is controlled by conformational changes of a conserved Asp-Phe-Gly (DFG) motif. We used an infrared probe to track the DFG motif of the mitotic kinase Aurora A (AurA) and found that allosteric activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d6b0303cace0b3d7fb7d911f77d42de
https://doi.org/10.1038/nchembio.2296
https://doi.org/10.1038/nchembio.2296
Autor:
Joseph M. Muretta, Steven K. Albanese, Sonya M. Hanson, David D. Thomas, John D. Chodera, Julie M. Behr, Andrew R. Thompson, Nicholas M. Levinson, Soreen Cyphers, Eric W. Lake, Emily F. Ruff
Publikováno v:
eLife
eLife, Vol 7 (2018)
eLife, Vol 7 (2018)
Many eukaryotic protein kinases are activated by phosphorylation on a specific conserved residue in the regulatory activation loop, a post-translational modification thought to stabilize the active DFG-In state of the catalytic domain. Here we use a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae27425896dbff034463448cee527db
http://europepmc.org/articles/PMC5849412
http://europepmc.org/articles/PMC5849412